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2014 | 9 | 1 | 148-158
Tytuł artykułu

Melatonin protection against burn-induced liver injury. A review

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Severe thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
1
Strony
148-158
Opis fizyczny
Daty
wydano
2014-02-01
online
2014-02-04
Twórcy
  • Department of General and Clinical Pathology, Medical University-Varna, Varna, Bulgaria
  • Division of Pathophysiology, Medical University, Varna, Bulgaria
  • Division of Pathophysiology, Medical University, Varna, Bulgaria
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0253-7
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