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2013 | 8 | 5 | 648-651
Tytuł artykułu

Lung emphysema treated successfully using volume reduction with lung sealant (AeriSeal®)

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Emphysema is a progressive and irreversible disease for which there is no cure to date. Endoscopic lung volume reduction with valve implantation or using lung sealant is a treatment option for patients with severe emphysema. A 60-year-old ex-smoker (80 pack years) referred to our center because of severe lung emphysema with progressive worsening of the obstructive ventilator pattern and clinical condition. By our patient we detected collateral channels by using the Chartis system®, which allow airflow into the target lobe and prevent atelectasis and significant lung volume reduction. Thus, we decided to treat the advanced emphysema of our patient with endoscopic volume reduction using lung sealant (AeriSeal®). The foam of lung sealant AeriSeal® is instilled into the peripheral airways and alveoli where it polymerizes and functions as tissue glue, forming a film of material on the lung surface that seals the target region to cause durable absorption atelectasis. Over a period of 16 weeks, the air within the sealed region was absorbed. The follow- up evaluation of this patient showed improved lung function (increased FEV 1, and a reduction of TLC and RV) with improved quality of life. Correlation between changes in primary and secondary outcome measures in the lung function parameters and 6- minute-walking test before and after the application of AeriSealant revealed significant reduction of hyperinflation and improvement both in the flow rates and physical capacity of our patient.
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
5
Strony
648-651
Opis fizyczny
Daty
wydano
2013-10-01
online
2013-09-18
Twórcy
autor
  • Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Str. 18, 70839, Stuttgart-Gerlingen, Germany
  • Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Str. 18, 70839, Stuttgart-Gerlingen, Germany, Roger-Fei.Falkenstern-Ge@rbk.de
  • Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Str. 18, 70839, Stuttgart-Gerlingen, Germany
  • Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Str. 18, 70839, Stuttgart-Gerlingen, Germany
Bibliografia
  • [1] Herth FJ, Gompelmann D, Stanzel F et. al Treatment of advanced emphysema with emphysematous lung sealant (AeriSeal®). Respiration. 2011;82(1):36–45. Epub 2011 Jan 11 http://dx.doi.org/10.1159/000322649[WoS][Crossref]
  • [2] Criner GJ, Sternberg AL. National Emphysema Treatment Trial: the major outcomes of lung volume reduction surgery in severe emphysema. Proc Am Thorac Soc. 2008 May 1;5(4):393–405 http://dx.doi.org/10.1513/pats.200801-013ET[Crossref]
  • [3] Shah PL, Slebos DJ, Cardoso PF, et al. Bronchoscopic lung- volume reduction with Exhale airway stents for emphysema (EASE trial): randomised, sham- controlled, multicentre trial. Lancet 2011; 378: 997–1005 http://dx.doi.org/10.1016/S0140-6736(11)61050-7[Crossref]
  • [4] Sciurba FC, Ernst A, Herth FJ, et al. A randomized study of endobronchial valves for advanced emphysema. N Eng J Med 2010; 363: 1233–1244 http://dx.doi.org/10.1056/NEJMoa0900928[Crossref]
  • [5] Maxfield RA. New and emerging minimally invasive techniques for lung volume reduction. Chest 2004;125:777–783 http://dx.doi.org/10.1378/chest.125.2.777[Crossref]
  • [6] Ingenito EP, Berger RL, Henderson AC, Reilly JJ, Tsai L, Hoffman A. Bronchoscopic lung volume reduction using tissue engineering principles. Am J Respir Crit Care Med 2003;167:771–778 http://dx.doi.org/10.1164/rccm.200208-842OC[Crossref]
  • [7] Ingenito EP, Douglas E. Wood, and James P. Utz Bronchoscopic Lung Volume Reduction in Severe Emphysema Proc Am Thorac Soc 2008 May 1;5(4):454–460 http://dx.doi.org/10.1513/pats.200707-085ET[Crossref]
  • [8] Herth FJ, Eberhardt R, Ingenito EP and Gompelmann D. Assessment of a novel lung sealant for performing endoscopic volume reduction therapy in patients with advanced emphysema. Expert Rev Med Devices 2011 8(3), 307–312 http://dx.doi.org/10.1586/erd.11.10[Crossref][WoS]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0187-0
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