PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2013 | 8 | 4 | 443-449
Tytuł artykułu

The effects of a 6-OHDA induced lesion in murine nuccleus accumbens on memory and oxidative stress status

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Nucleus accumbens (NAcc) are a collection of neurons that form the main part of the ventral striatum, which is a significant dopaminergic structure. Also, NAcc is thought to play an important role in reward, pleasure, laughter, addiction, aggression, fear, and the placebo effect. In the present work we were interested in studying the effects of a 6-OHDA induced lesion in the nucleus accumbens (NAcc), which is known as an important dopaminergic structure, on a specific behavioral task that involves both short term and long term spatial memory (the radial-8-arm-maze task), as well as on the oxidative stress markers (two antioxidant enzymes: superoxide dismutase-SOD and glutathione peroxidase-GPX and a lipid peroxidation marker: malondialdehyde-MDA, as well as the total antioxidant status-TAS) from the temporal lobe, which is considered to be the most vulnerable cortical area to oxygen levels fluctuations and hypoxia. Our results showed some significant effects of this lesion on the reference memory errors and time necessary to finish the test in the radial-8-arm-maze task. Additionally, increased oxidative stress status was demonstrated in the temporal lobe of the lesioned rats, as demonstrated by the high levels of lipid peroxidation and decreased total antioxidant status. Moreover, significant correlations are reported here between the behavioral parameters which we studied in the radial-8-arm-maze task and the aforementioned oxidative stress markers.
Wydawca
Czasopismo
Rocznik
Tom
8
Numer
4
Strony
443-449
Opis fizyczny
Daty
wydano
2013-08-01
online
2013-06-12
Twórcy
autor
  • “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania
  • “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania
  • “Gr. T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115, Iasi, Romania
  • “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania
  • “Alexandru Ioan Cuza” University, Bd. Carol I, nr. 11, Iasi, 700506, Romania
Bibliografia
  • [1] Cousins MS, Salamone JD. Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure. Pharmacol Biochem Behav 1994;49:85–91 http://dx.doi.org/10.1016/0091-3057(94)90460-X[Crossref]
  • [2] Parkinson JA, Dalley JW, Cardinal RN, Bamford A, Fehnert B, Lachenal G, Rudarakanchana N, Halkerston KM, Robbins TW, Everitt BJ. Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function. Behav Brain Res 2002;137:149–163 http://dx.doi.org/10.1016/S0166-4328(02)00291-7[Crossref]
  • [3] Fernandez Espejo E. Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory. Neuropsychopharmacology 2003;28:490–498 http://dx.doi.org/10.1038/sj.npp.1300066[Crossref]
  • [4] Schildein S, Huston JP, Schwarting RK. Open field habituation learning is improved by nicotine and attenuated by mecamylamine administered posttrial into the nucleus accumbens. Neurobiol Learn Mem 2002;77:277–290 http://dx.doi.org/10.1006/nlme.2001.4017[Crossref]
  • [5] Schildein S, Huston JP, Schwarting RK. Injections of tacrine and scopolamine into the nucleus accumbens: opposing effects of immediate vs delayed posttrial treatment on memory of an open field. Neurobiol Learn Mem 2000;73:21–30 http://dx.doi.org/10.1006/nlme.1999.3915[Crossref]
  • [6] Hagan JJ, Alpert JE, Morris RG, Iversen SD. The effects of central catecholamine depletions on spatial learning in rats. Behav Brain Res 1983;9:83–104 http://dx.doi.org/10.1016/0166-4328(83)90015-3[Crossref]
  • [7] Dalley JW, Chudasama Y, Theobald DE, Pettifer CL, Fletcher CM, Robbins TW. Nucleus accumbens dopamine and discriminated approach learning: interactive effects of 6-hydroxydopamine lesions and systemic apomorphine administration. Psychopharmacology (Berl) 2002;161:425–433 http://dx.doi.org/10.1007/s00213-002-1078-2[Crossref]
  • [8] Wolterink G, Phillips G, Cador M, Donselaar-Wolterink I, Robbins TW, Everitt BJ. Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement. Psychopharmacology (Berl) 1993;110:355–364 http://dx.doi.org/10.1007/BF02251293[Crossref]
  • [9] Grigoryan G, Hodges H, Mitchell S, Sinden JD, Gray JA. 6-OHDA lesions of the nucleus accumbens accentuate memory deficits in animals with lesions to the forebrain cholinergic projection system: effects of nicotine administration on learning and memory in the water maze. Neurobiol Learn Mem 1996;65:135–153 http://dx.doi.org/10.1006/nlme.1996.0016
  • [10] Stefanescu C, Ciobica A. The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord 2012, doi 10.1016/j. jad.2012.05.022 [WoS][Crossref]
  • [11] Ciobica A, Padurariu M, Dobrin I, Stefanescu C, Dobrin R. Oxidative stress in schizophrenia - focusing on the main markers. Psychiatr Danub 2011;23:237–245
  • [12] Ciobica A, Veronica Bild, Lucian Hritcu, Manuela Padurariu, Walther Bild. Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat. Central European Journal of Medicine 2011;6:331–340 http://dx.doi.org/10.2478/s11536-011-0010-8[WoS][Crossref]
  • [13] Ciobica A, Olteanu Z, Padurariu M, Hritcu L. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease. J Physiol Biochem 2012;68:59–69 http://dx.doi.org/10.1007/s13105-011-0119-x[Crossref][WoS]
  • [14] Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. The cerebrocortical areas in normal brain aging and in Alzheimer’s disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochem Res 2001;26:353–361 http://dx.doi.org/10.1023/A:1010942929678[Crossref]
  • [15] Reading PJ, Dunnett SB. The effects of excitotoxic lesions of the nucleus accumbens on a matching to position task. Behav Brain Res 1991;46:17–29 http://dx.doi.org/10.1016/S0166-4328(05)80093-2[Crossref]
  • [16] Miller R, Wickens JR, Beninger RJ. Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs. Prog Neurobiol 1990;34:143–183 http://dx.doi.org/10.1016/0301-0082(90)90005-2[Crossref]
  • [17] Weiner I. Shofel A, Feldon J. Disruption of latent inhibition by low dose of amphetamine is antagonized by haloperidol and apomorphine. Journal of Psychopharmacology 1990;4:255
  • [18] Schacter GB., Yang CR., Innis NK., Mogenson GJ. The role of the hippocampal-nucleus accumbens pathway in radial-arm maze performance. Brain Research 1989;494:339–349 http://dx.doi.org/10.1016/0006-8993(89)90602-1[Crossref]
  • [19] Winnicka MM. Dopaminergic projection to the nucleus accumbens mediates the memoryenhancing effect of angiotensins in rats. Pharmacol Biochem Behav 1999;62:625–630 http://dx.doi.org/10.1016/S0091-3057(98)00199-3[Crossref]
  • [20] Zeng BY, Dass B, Owen A, Rose S, Cannizzaro C, Tel BC, Jenner P. 6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats. Neurosci Lett. 2002;322:33–36 http://dx.doi.org/10.1016/S0304-3940(02)00083-6[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0165-6
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.