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2013 | 8 | 4 | 468-475
Tytuł artykułu

The possible protective mechanism of Hyperbaric oxygen (HBO) in memory impairments induced by Aβ25–35 in rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Alzheimer’s disease is characterized by the accumulation and deposition of Aβ peptides in human brains. Aβ peptides are toxic to neurons by lots of mechanisms of which Aβ induced oxidative stress is one of the hypothesis. The present study aimed to determine the effect of Hyperbaric oxygen (HBO) on Aβ25–35 induced cognitive deficits and oxidative stress and apoptosis effects in rats. Rats were given an injection of aggregated Aβ25–35. After treatment with HBO for 20days, the learning and memory ability, hippocampus neuronal apoptosis, the activity of SOD, GSH content and the MDA level and mRNA and proteins expression of Bcl-2 and Bax were detected. Our results demonstrated that HBO could significantly improved the apoptosis hippocampus neuronal induced by Aβ25–35, involving the improvement of the learning and memory impairment, which accompanied of increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content. These findings suggest that treatment of HBO might prevent the Aβ25–35 induced learning and memory impairment by increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content to alleviate the apoptosis hippocampus neuronal. This suggests that HBO may be a potential therapeutic agent for AD.
Wydawca
Czasopismo
Rocznik
Tom
8
Numer
4
Strony
468-475
Opis fizyczny
Daty
wydano
2013-08-01
online
2013-06-12
Twórcy
  • School of Medicine, Southeast University, Nanjing, China
autor
  • Affiliated Zhongda Hospital of Southeast University, Nanjing, China
autor
  • Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
autor
  • Department of Pathology, Nanjing University of Traditional Chinese Medicine, Nanjing, China
  • Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
autor
  • School of Medicine, Southeast University, Nanjing, China
autor
Bibliografia
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  • [8] Yong-Chun Wang, Shu Zhang, Ting-Yuan Du, et al. (2010) HBO preconditioning reduces ischemia-reperfusion injury by stimulating autophagy in neurocyte. BRAINRESEARCH.1323:149–151
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  • [10] Hakan Ay, Turgut Topal, Mehmet Özler, et al (2007). Persistence of HBO-induced oxidative effects after exposure in rat brain cortex tissue. Life Sciences. 80: 2025–2029 http://dx.doi.org/10.1016/j.lfs.2007.03.002[WoS][Crossref]
  • [11] Andreas Rothfuss, Günter Speit.(2002) Investigations on the mechanism of HBO-induced adaptive protection against oxidative stress. Mutation Research. 508:157–165 http://dx.doi.org/10.1016/S0027-5107(02)00213-0[Crossref]
  • [12] JW Calvert, C Zhou, A Nanda, et al.(2003) Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model, J. Appl. Physiol. 95: 2072–2080
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  • [15] Ved Chauhan, Abha Chauhan. (2006) Oxidative stress in Alzheimer’s disease. Pathophysiology 13:195–208 http://dx.doi.org/10.1016/j.pathophys.2006.05.004[Crossref]
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  • [18] Ruan CJ, Zhang L, Chen DH, et al. (2010) Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Aβ25–35 both in vitro and in vivo. Neuroscience Research. 67:209–214 http://dx.doi.org/10.1016/j.neures.2010.03.009[WoS][Crossref]
  • [19] Zola-Morgan S, Squire LR, Amaral DG. (1986) Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. 6:2950–2967
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  • [22] Jasenka Mršić-Pelčí, Goran Pelčić, Dinko Vitezić, et al. (2004) HBO treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats. Neurochemistry International. 44:585–594 http://dx.doi.org/10.1016/j.neuint.2003.10.004[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-013-0163-8
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