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2013 | 8 | 2 | 204-207
Tytuł artykułu

LDOC-1 and PARP-1 mRNA expression in leukocytes of father and son with cutaneous malignant melanoma

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Apoptosis is central to the biology of cutaneous malignant melanoma (CMM). The leucine zipper, down regulated in cancer 1 (LDOC-1) gene, is known to be a regulator of the nuclear factor kappa B (NF-kB) through inhibition of the same NF-kB. The poly (ADP-ribose) polymerase-1 (PARP1) gene plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required for the apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. We report here two interesting cases of family melanoma, a father and son 84 and 40 years old, respectively. The histological evaluation of the lesions of both men revealed diffused superficial melanoma with epithelioid cells. We evaluated the differential expression of LDOC-1 and PARP-1 mRNA in peripheral blood leukocytes of both the father and son. We found that both LDOC-1 and PARP-1 genes were down-regulated in both patients compared with those of controls. These data suggest that low levels of expression of LDOC-1 and PARP-1 mRNA may be associated with familial melanoma.
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
2
Strony
204-207
Opis fizyczny
Daty
wydano
2013-04-01
online
2013-01-23
Twórcy
  • Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, via S. Sofia 78, 95123, Catania, Italy, micezia@tiscali.it
autor
  • Plastic Surgery and Burns Centre, Cannizzaro Hospital, Catania, Italy
  • Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, via S. Sofia 78, 95123, Catania, Italy
  • Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, via S. Sofia 78, 95123, Catania, Italy
  • Section of Endocrinology, Andrology and Internal Medicine, Department of Internal Medicine and Systemic Diseases, University of Catania, via S. Sofia 78, 95123, Catania, Italy
Bibliografia
  • [1] de Vries E., Coebergh JW.: Melanoma incidence has risen in Europe, B.M.J., 2005,331, 698 http://dx.doi.org/10.1136/bmj.331.7518.698[Crossref]
  • [2] Tumino R., Frasca G., Palli D., Masala G., Tagliabue G., Evangelista A., Giurdanella MC., Vineis P., Veglia F., Celentano E., Galasso R., Cascone G.: Cancer incidence in EPIC-ITALY at first follow-up, Tumori., 2003,89,656–664
  • [3] Hu W., Kavanagh JJ.: Anticancer therapy targeting the apoptotic pathway, Lancet. Oncol., 2003,4, 721–729 http://dx.doi.org/10.1016/S1470-2045(03)01277-4[Crossref]
  • [4] Nagasaki K., Manabe T., Hanzawa H., Maass N., Tsukada T., Yamaguchi K.: Identification of a novel gene, LDOC1, down-regulated in cancer cell lines, Cancer. Lett., 1999,140,227–234 http://dx.doi.org/10.1016/S0304-3835(99)00087-7[Crossref]
  • [5] Inoue M., Takahashi K., Niide O., Shibata M., Fukuzawa M., Ra C.: LDOC1, a novel MZF-1-interacting protein, induces apoptosis, FEBS. Lett., 2005,579,604–608 http://dx.doi.org/10.1016/j.febslet.2004.12.030[Crossref]
  • [6] Yu SW., Wang H., Poitras MF., Coombs C., Bowers WJ., Federoff HJ., Poirier GG., Dawson TM., Dawson VL.: Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing Factor, Science., 2002,297,259–263 http://dx.doi.org/10.1126/science.1072221[Crossref]
  • [7] Yu SW., Andrabi SA., Wang H.: Apoptosis-inducing factor mediates poly (ADP-ribose) (PAR) polymerinduced cell death, Proc. Natl. Acad. Sci. USA., 2006,103,18314–18319 http://dx.doi.org/10.1073/pnas.0606528103[Crossref]
  • [8] Hassa PO., and Hottiger MO.: The diverse biological roles of mammalian PARPs, a small but powerful family of poly-ADP-ribose polymerases, Front. Biosci., 2008,13,3046–3082 http://dx.doi.org/10.2741/2909[Crossref][WoS]
  • [9] Livak KJ., Schmittgen TD.: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method, Methods., 2001,4,402–408 http://dx.doi.org/10.1006/meth.2001.1262[Crossref]
  • [10] Salemi M., Giuffrida D., Soma PF., Giuffrid MC., Galia A., Calogero AE.: Two proapoptotic genes are downregulated in a patient with melanoma and repeated in-transit metastases, Am. J. Dermatopathol., 2012, 34,454–455 http://dx.doi.org/10.1097/DAD.0b013e31820a4bd7[WoS][Crossref]
  • [11] Mizutani K., Koike D., Suetsugu S., Takenawa T.: WAVE3 functions as a negative regulator of LDOC1. J. Biochem, 2001,38,639–646
  • [12] Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N.: Leucinezipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis, Int. J. Cancer.,2003,105,454–458 http://dx.doi.org/10.1002/ijc.11122[Crossref]
  • [13] Andrabi SA., Kim NS., Yu SW. Poly(ADP-ribose) (PAR) polymer is a death signal, Proc. Natl. Acad. Sci. USA, 2006,103,18308–18313 http://dx.doi.org/10.1073/pnas.0606526103[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-012-0121-x
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