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2013 | 8 | 1 | 84-89
Tytuł artykułu

Leptospirosis: possibilities of early laboratory and clinical diagnosis

Treść / Zawartość
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Języki publikacji
EN
Abstrakty
EN
This retrospective study aims to identify and describe the problems associated with the laboratory and clinical diagnosis of leptospirosis. A total of 4,813 patients with suspected leptospirosis from an area of the Czech Republic, with a total population of 1.15 million, were examined during the period 2002–2010. Our study included only 855 patients: 545 men (mean age 41.03 ± 19.24) and 310 women (mean age 41.47 ± 20.3) who were examined using microscopic agglutination test (MAT) and a polymerase chain reaction (PCR). All patients and their physicians filled in questionnaires, which included anamnestic data, clinical symptoms and the results of laboratory tests. Out of total suspected, 89 patients (1.85%), tested positive for leptospirosis, of which 50 have been examined only serologically by MAT. Of 855 patients in our study undergoing both PCR and MAT tests, 39 have tested positive for leptospirosis. The most frequent symptom in patients with leptospirosis included fever (91.6%) and headache (69.4%). The correct laboratory diagnosis of leptospirosis depends on biological material being tested before the start of antibiotic treatment, since leptospires are extremely sensitive to antibiotics. Consequently, the PCR results alone may produce a false negative result after 24 hours following treatment with antibiotics.
Wydawca

Czasopismo
Rocznik
Tom
8
Numer
1
Strony
84-89
Opis fizyczny
Daty
wydano
2013-02-01
online
2012-12-08
Twórcy
  • Department of Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
  • Department of Clinical Biochemistry and Diagnostics, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
autor
  • Department of Infectious Diseases, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
  • Department of Clinical Microbiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
  • Department of Clinical Microbiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
autor
  • Department of Infectious Diseases, Faculty Hospital and Faculty of Medicine, Masaryk University, Jihlavska 20, 625 00, Brno, Czech Republic
autor
  • Department of Clinical Microbiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove and University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
Bibliografia
  • [1] Abgueguen P., Delbos V., Blanvillain J., Chennebault J.M., Cottin J., Fanello S., et al., Clinical Aspects and Prognostic Factors of Leptospirosis in Adults. Retrospective Study in France, J. Infect., 2008, 57, 171–178 http://dx.doi.org/10.1016/j.jinf.2008.06.010[WoS][Crossref]
  • [2] Vinetz J.M., Glass G.E., Flexner C.E., Mueller P., Kaslow D.C., Sporadic Urban Leptospirosis, Ann. Intern. Med., 1996, 125, 794–798 [Crossref]
  • [3] Ittyachen A.M., Krishnapillai T.V., Nair M.C., Rajan A.R., Retrospective Study of Severe Cases of Leptospirosis Admitted in the Intensive Care Unit, J Postgrad Med., 2007, 53, 232–235 http://dx.doi.org/10.4103/0022-3859.37510[Crossref]
  • [4] Perić L., Simasek D., Barbić J., Perić N., Prus V., Sisljagić V., et al., Human Leptospirosis in Eastern Croatia, 1969–2003: Epidemiological, Clinical, and Serological Features, Scand. J. Infect. Dis., 2005, 37, 738–741 http://dx.doi.org/10.1080/00365540510012170[Crossref]
  • [5] Pappas G., Papadimitriou P., Siozopoulou V., Christou L., Akritidis N., The Globalization of Leptospirosis: Worldwide Incidence Trends, Int. J. Infect. Dis., 2008, 12, 351–357 http://dx.doi.org/10.1016/j.ijid.2007.09.011[WoS][Crossref]
  • [6] Plank R., Dean D., Overview of the Epidemiology, Microbiology, and Pathogenesis of Leptospira spp. in Humans, Microbes Infect., 2000, 2, 1265–1276 http://dx.doi.org/10.1016/S1286-4579(00)01280-6[Crossref]
  • [7] Nardone A., Capek I., Baranton G., Campèse C., Postic D., Vaillant V., et al., Risk Factors for Leptospirosis in Metropolitan France: Results of a National Case-control Study, 1999–2000, Clin. Infect. Dis., 2004, 39, 751–753 http://dx.doi.org/10.1086/423272[Crossref]
  • [8] Xue F., Yan J., Picardeau M., Evolution and Pathogenesis of Leptospira spp.: Lessons Learned from the Genomes, Microbes Infect., 2009, 11, 328–333 http://dx.doi.org/10.1016/j.micinf.2008.12.007[Crossref][WoS]
  • [9] Vinetz J.M., Leptospirosis, Curr. Opin. Infect. Dis., 2001, 14, 527–538. http://dx.doi.org/10.1097/00001432-200110000-00005[Crossref]
  • [10] Terpstra W.J., Historical Perspectives in Leptospirosis, Indian J Med Microbiol., 2006, 24, 316–320 http://dx.doi.org/10.4103/0255-0857.29407[Crossref]
  • [11] Sugathan S., Verghese T.P., Multiplex PCR on Leptospiral Isolates from Kolenchery, Kerala, India, Indian J Med Microbiol., 2005, 23, 114–116 http://dx.doi.org/10.4103/0255-0857.16051[Crossref]
  • [12] Brown P.D., Gravekamp C., Carrington D.G., van de Kamp H., Hartskeerl R.A., Edwards C.N., et al., Evaluation of the Polymerase Chain Reaction for Early Diagnosis of Leptospirosis, J. Med. Microbiol., 1995, 43, 110–114 http://dx.doi.org/10.1099/00222615-43-2-110[Crossref]
  • [13] Nizamuddin M., Tuteja U., Shukla J., Nair L., Sudarsana J., Early Diagnosis of Human Leptospirosis by Antigen Detection in Blood, Indian J Med Microbiol., 2006, 24, 342–345 http://dx.doi.org/10.4103/0255-0857.29415[Crossref]
  • [14] Romero E.C., Billerbeck A.E., Lando V.S., Camargo E.D., Souza C.C., Yasuda P.H., Detection of Leptospira DNA in Patients with Aseptic Meningitis by PCR, J. Clin. Microbiol., 1998, 36, 1453–1455
  • [15] Krøjgaard L.H., Villumsen S., Markussen M.D., Jensen J.S., Leirs H., Heiberg A.C., High Prevalence of Leptospira spp. in Sewer Rats (Rattus norvegicus), Epidemiol. Infect., 2009, 137, 1586–1592 http://dx.doi.org/10.1017/S0950268809002647[Crossref][WoS]
  • [16] Terpstra W.J. et al., Human Leptospirosis: Guidance for Diagnostic, Surveillance and Control., World Health Organization, International Leptospirosis Society, Malta, 2003, ISBN 92 4 154589 5
  • [17] Gravekamp C., Van de Kemp H., Franzen M., Carrington D., Schoone G.J., Van Eys G.J., et al., Detection of Seven of Pathogenic Leptospires by PCR Using Two Sets of Primers, J. Gen. Microbiol., 1993, 139, 1691–1700 http://dx.doi.org/10.1099/00221287-139-8-1691[Crossref]
  • [18] Katz A.R., Ansdell V.E., Effler P.V., Middleton C.R., Sasaki D.M., Assessment of the Clinical Presentation and Treatment of 353 Cases of Laboratory-confirmed Leptospirosis in Hawaii, 1974–1998, Clin. Infect. Dis., 2001, 33, 1834–1841 http://dx.doi.org/10.1086/324084[Crossref]
  • [19] Covic A., Goldsmith D.J., Gusbeth-Tatomir P., Seica A., Covic M., A Retrospective 5-year Study in Moldova of Acute Renal Failure Due to Leptospirosis: 58 Cases and a Review of the Literature, Nephrol. Dial. Transplant., 2003, 18, 1128–1134 http://dx.doi.org/10.1093/ndt/gfg095[Crossref]
  • [20] Mansour-Ghanaei F., Sarshad A., Fallah M.S., Pourhabibi A., Pourhabibi K., Yousefi-Mashhoor M., Leptospirosis in Guilan, a Northern Province of Iran: Assessment of the Clinical Presentation of 74 Cases, Med. Sci. Monit., 2005, 11, CR219–223
  • [21] Esen S., Sunbul M., Leblebicioglu H., Eroglu C., Turan D., Impact of Clinical and Laboratory Findings on Prognosis in Leptospirosis, Swiss Med Wkly., 2004, 134, 347–352
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-012-0110-0
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