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2012 | 7 | 5 | 659-664
Tytuł artykułu

Asymmetric and symmetric dimethylarginine in patients presenting with risk factors for coronary heart disease

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the present study was to investigate asymmetric (ADMA) and symmetric dimethylarginine (SDMA) production in patients presenting with one or more risk factor (RF) for coronary heart disease (CHD). Patients and methods: Overall, 113 participants were enrolled in the study, including 45 patients presenting with risk for CHD (27 male and 18 female; aged 55.9 ± 6.4 years), 30 sex and age-matched middle-aged healthy controls (16 male and 14 female; aged 56.3 ± 8.4 years), and 38 young healthy controls (38 male; aged 24.6 ± 3.9 years). Results: No significant differences for ADMA and SDMA were recorded between patients groups presenting with risk for CHD. However, ADMA and SDMA were significantly higher in all examined patient groups (≥3 and 1–2 RF, hypertensive and non-hypertensive, obese and non-obese, diabetics and non-diabetics) compared with both control groups (middle-aged and young controls) (p<0.001). ADMA significantly correlated with SDMA in ≥3 RF (p<0.05), hypertensive (p<0.05), non-obese (p<0.05), non-diabetics (p<0.01), as well in middle-aged (p<0.05) and young controls (p<0.001). Conclusion: Significantly higher ADMA and SDMA were found between patients presenting with risk for CHD (≥3 and 1–2 RF, hypertensive and nonhypertensive, obese and non-obese, diabetics and non-diabetics) and healthy, middle-aged and young controls. ADMA significantly correlated with SDMA in ≥3 RF, hypertensive, non-obese and non-diabetic patients, as well as in middle-aged and young controls.
Wydawca

Czasopismo
Rocznik
Tom
7
Numer
5
Strony
659-664
Opis fizyczny
Daty
wydano
2012-10-01
online
2012-07-28
Twórcy
autor
  • Institute of Cardiology, Niska Banja, Faculty of Medicine, University of Nis, 18000, Nis, Serbia, marinadi@open.telekom.rs
  • Institute of Chemistry, Faculty of Medicine, University of Nis, 18000, Nis, Serbia
  • Clinic of Cardiology, Clinical Center, Nis, 18000, Nis, Serbia
  • Institute of Biochemistry, Faculty of Medicine, University of Nis, 18000, Nis, Serbia
  • Institute of Biochemistry, Faculty of Medicine, University of Nis, 18000, Nis, Serbia
autor
  • Institute of Cardiology, Niska Banja, Faculty of Medicine, University of Nis, 18000, Nis, Serbia
  • Institute of Nephrology, Faculty of Medicine, University of Nis, 18000, Nis, Serbia
Bibliografia
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  • [6] Krzyzanowska K, Mittermayer F, Wolzt M, Schernthaner G. Asymmetric dimethylarginine predicts cardiovascular events in patients with Type 2 diabetes. Diabetes Care 2007; 30: 1834–1839 http://dx.doi.org/10.2337/dc07-0019[WoS]
  • [7] Meinitzer, Seelhorst U, Wellnitz B, Schernthaner G. Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study). Clin Chem 2007; 53:273–283 http://dx.doi.org/10.1373/clinchem.2006.076711[Crossref]
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  • [9] Eid HM, Arnesen H, Hjerkinn EM, Lyberg T, Seljeflot I. Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine. Metabolism 2004; 53:1574–1579 http://dx.doi.org/10.1016/j.metabol.2004.06.026[Crossref]
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  • [19] Cetinalp-Demircan P, Can A, Bekpinar S, Unlucerci Y, Orhan Y. Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease. Endocrine 2007; 31:100–104 http://dx.doi.org/10.1007/s12020-007-0005-z[WoS][Crossref]
  • [20] Abbasi F, Asagmi T, Cooke JP, Lamendola C, McLaughlin T, Reaven GM, Stuehlinger M, Tsao PS. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol 2001; 88: 201–1203 http://dx.doi.org/10.1016/S0002-9149(01)02063-X[Crossref]
  • [21] Candido R, Zanetti M. Endothelial dysfunction in diabetic vascular disease, Ital Heart J 2005; 6: 703–720
  • [22] Lenzen H, Tsikas D, Böger RH. Asymmetric dimethylarginine (ADMA) and the risk for coronary heart disease: the multicenter CARDIAC study. Eur J Clin Pharmacol 2006; 62: 45–49 http://dx.doi.org/10.1007/s00228-005-0014-x[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-012-0031-y
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