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Czasopismo
2012 | 7 | 3 | 305-309
Tytuł artykułu

Subclinical tumor lysis-like syndrome during treatment of visceral leishmaniasis with low-dose intermittent liposomal amphotericin B

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We retrospectively evaluated the rate of renal dysfunction during treatment with liposomal amphotericin B (L-AmB) (3–4 mg/kg, for 7–10 days) in nine consecutive patients with visceral leishmaniasis (VL). During the first week of treatment, 5 patients (56%) experienced transient deterioration of renal function, with a rise in serum creatinine to 1.27–2.44 times the baseline level, and a parallel elevation of uric acid levels without other metabolic or electrolyte disturbances. Serum renal function parameters were restored to normal levels after the completion of therapy, on day 21. These 5 patients had presented with prolonged fever and/or significant spleen enlargement, reflecting high parasite load. This observation suggests that treatment of VL with intermittent L-AmB causes a subclinical tumor lysis-like syndrome, especially in patients with high parasite load.
Wydawca

Czasopismo
Rocznik
Tom
7
Numer
3
Strony
305-309
Opis fizyczny
Daty
wydano
2012-06-01
online
2012-03-29
Twórcy
  • Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece, sgeorg@med.uth.gr
  • Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, Texas, USA
  • Infectious Diseases Unit, Pathophysiology Department, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str, 11527, Athens, Greece
Bibliografia
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  • [10] Ullmann AJ, Sanz MA, Tramarin A, Barnes RA, Wu W, Gerlach BA, et al. Longitudinal Evaluation of Antifungal Drugs (LEAD I) Investigators. Prospective study of amphotericin B formulations in immunocompromised patients in 4 European countries. Clin Infect Dis 2006, 43, 29–38 [Crossref]
  • [11] Meyerhoff A. U.S. Food and Drug Administration approval of AmBisome (liposomal amphotericin B) for treatment of visceral leishmaniasis. Clin Infect Dis. 1999, 28, 42–48 http://dx.doi.org/10.1086/515085[Crossref]
  • [12] Bern C, Adler-Moore J, Berenguer J, Boelaert M, den Boer M, Davidson RN, et al. Liposomal amphotericin B for the treatment of visceral leishmaniasis. Clin Infect Dis. 2006, 43, 917–924 http://dx.doi.org/10.1086/507530[Crossref]
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  • [15] Liberopoulos E, Alexandridis G, Elisaf M. A tumor lysis-like syndrome during therapy of visceral leishmaniasis. Ann Clin Lab Sci 2002, 32, 419–421
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  • [17] Cairo MS, Bishop M. Tumor lysis syndrome: new therapeutic strategies and classification. Br J Haematol 2004, 127, 3–11 http://dx.doi.org/10.1111/j.1365-2141.2004.05094.x[Crossref]
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  • [19] Shaha C. Apoptosis in Leishmania species and its relevance to disease pathogenesis. Indian J Med Res. 2006, 123, 233–244
  • [20] Sundar S, Mehta H, Suresh AV, Singh SP, Rai M, Murray HW. Amphotericin B treatment for Indian visceral leishmaniasis: conventional versus lipid formulations. Clin Infect Dis 2004, 38, 377–383 http://dx.doi.org/10.1086/380971[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0147-5
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