Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 7 | 1 | 1-8
Tytuł artykułu

Brain asymmetry, immunity, handedness

Treść / Zawartość
Warianty tytułu
Języki publikacji
The principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.
Słowa kluczowe

Opis fizyczny
  • Department of Physiology and Pathophysiology, Medical University “Prof. Paraskev Stoyanov”, 55 Marin Drinov Str., 9002, Varna, Bulgaria,
  • Department of Physiology and Pathophysiology, Medical University “Prof. Paraskev Stoyanov”, 55 Marin Drinov Str., 9002, Varna, Bulgaria
  • Department of Physiology and Pathophysiology, Medical University “Prof. Paraskev Stoyanov”, 55 Marin Drinov Str., 9002, Varna, Bulgaria
  • Department of Physiology and Pathophysiology, Medical University “Prof. Paraskev Stoyanov”, 55 Marin Drinov Str., 9002, Varna, Bulgaria
  • [1] Davidson R.J., Hugdahl K. (Eds.), Brain asymmetry, MIT Press, Cambridge, MA, 1995
  • [2] Galderisi S., Mucci A., Maj M., Brain hemispheric organization, anxiety, and psychoses, CNS Spectr., 2000, 5, 58–69
  • [3] Zaidel E., Brain asymmetry, In: Smelser N.J., Baltes P.B. (Eds.), International encyclopedia of the social & behavioral sciences, 1st ed., Elsevier Science Ltd., Oxford, 2001
  • [4] Tao S., Walsh C.A., Molecular approaches to brain asymmetry and handedness, Nat. Rev. Neurosci., 2006, 7, 655–662
  • [5] Wittling W., Brain asymmetry in the control of autonomic-physiologic activity, In: ai]Davidson R.J., Hugdahl K. (Eds.), Brain asymmetry, MIT Press, Cambridge, MA, 1995
  • [6] Gerendai I., Halász B., Asymmetry of the neuroendocrine system, News Physiol. Sci., 2001, 16, 92–95
  • [7] Grabowska A., Herman A., Nowicka A., Szatkowska I., Szelag E., Individual differences in the functional asymmetry of the human brain, Acta Neurobiol. Exp. (Warsz) 1994, 54, 155–162
  • [8] Grimshaw G.M., Integration and interference in the cerebral hemispheres: relations with hemispheric specialization, Brain Cogn., 1998, 36, 108–127[Crossref]
  • [9] Toga A.W., Thompson P.M., Mapping brain asymmetry, Nat. Rev. Neurosci., 2003, 4, 37–48[Crossref]
  • [10] Medland S.E., Duffy D.L., Wright M.J., Geffen G.M., Hay D.A., Levy F., et al., Genetic influences on handedness: Data from 25,732 Australian and Dutch twin families, Neuropsychologia, 2009, 47, 330–337[Crossref]
  • [11] Semenov S.F., Chuprikov A.P., Asymmetry of brain injuries and immune-biological reactivity, Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, 1975, 12, 1798–1806, (in Russian)
  • [12] Bardos P., Degenne D., Lebranchu Y., Biziere K., Renoux G., Neokortical lateralization of NK activity in mice, Scand. J. Immunol., 1981, 13, 609–611[Crossref]
  • [13] Renoux G., Biziere K., Renoux M., Guillaumin J.M., Degenne D., A balanced brain asymmetry modulates T cell-mediated events, J. Neuroimmunol., 1983, 5, 227–238[Crossref]
  • [14] Barneoud P., Neveu P.J., Vitiello S., Mormede P., Le Moal M., Brain neocortex immunomodulation in rats, Brain Res., 1988, 474, 394–398[Crossref]
  • [15] Fu Q.L., Shen Y.Q., Gao M.X., Dong J., Neveu P.J., Li K.S., Brain interleukin asymmetries and paw preference in mice, Neuroscience, 2003, 116, 639–647[Crossref]
  • [16] Renoux G., Biziere K., Brain neocortex lateralized control of immune recognition, Integr. Psychiatry, 1986, 4, 32–40
  • [17] Kang D.H., Davidson R.J., Coe C.L., Wheeler R.E., Tomarken A.J., Ershler W.B., Frontal brain asymmetry and immune function, Behav. Neurosci., 1991, 105, 860–869[Crossref]
  • [18] Davidson R.J., Cerebral asymmetry, emotion and affective style, In: Davidson R.J., Hugdahl K. (Eds.), Brain asymmetry, MIT Press, Cambridge, MA, 1995
  • [19] Gruzelier J., Clow A., Evans P., Lazar I., Walker L., Mind-body influences on immunity: lateralized control, stress, individual difference predictors, and prophylaxis, Ann. N. Y. Acad. Sci., 1998, 851, 487–494[Crossref]
  • [20] Meador K.J., De Lecuona J.M., Helman S.W., Loring D.W., Differential immunologic effects of language-dominant and nondominant cerebral resections, Neurology, 1999, 52, 1183–1187 [Crossref]
  • [21] Betancur C., Sandi C., Vitiello S., Borrell J., Guaza C., Neveu P.J., Activity of hypothalamic-pituitaryadrenal axis in mice selected for left- and righthandedness, Brain Res., 1992, 589, 302–306[Crossref]
  • [22] Shen Y.Q., Hébert G., Moze E., Li K.S., Neveu P.J., Asymmetrical distribution of brain interleukin- 6 depends on lateralization in mice, Neuroimmunomodulation, 2005, 12, 189–194[Crossref]
  • [23] Nikolova P., Stoyanov Z., Negrev N., Functional brain asymmetry, handedness and menarcheal age, Int. J. Psychophysiol., 1994, 18, 213–215[Crossref]
  • [24] Nikolova P., Negrev N., Stoyanov Z., Nikolova R. Functional brain asymmetry, handedness and age characteristics of climacterium in women, Int. J. Neurosci., 1996, 86, 143–149[Crossref]
  • [25] Hori T., Katafuchi T., Take S., Shimizu N., Niijima A., The autonomic nervous system as a communication channel between the brain and the immune system, Neuroimmunomodulation, 1995, 2, 203–215[Crossref]
  • [26] Yoon B.W., Morillo C.A., Cechetto D.F., Hachinski V., Cerebral hemispheric lateralization in cardiac autonomic control, Arch. Neurol., 1997, 54, 741–744
  • [27] Wittling W., Brain asymmetry and autonomic control of the heart, Eur. Psychol., 1997, 2, 313–327[Crossref]
  • [28] Hilz M.J., Dütsch M., Perrine K., Nelson P.K., Rauhut U., Devinsky O., Hemispheric influence on autonomic modulation and baroreflex sensitivity, Ann. Neurol., 2001, 49, 575–584[Crossref]
  • [29] Foster P.S., Harrison D.W., Magnitude of cerebral asymmetry at rest: covariation with baseline cardiovascular activity, Brain Cogn., 2006, 61, 286–297[Crossref]
  • [30] Engel J., Pedley T.A. (Eds.), Epilepsy: a comprehensive textbook, Lippincott Williams & Wilkins, Philadelphia, PA, 2007
  • [31] Abramov V.V., Gontova I.A., Kozlov V.A., Functional asymmetry of the thymus and the immune response in mice, Neuroimmunomodulation, 2001, 9, 218–224[Crossref]
  • [32] Neveu P.J., The production and effects of cytokines depend on brain lateralization, Neuroimmune Biol., 2008, 6, 549–563[Crossref]
  • [33] Su Y., Xie Z., Xin G., Zhao L., Li K., Predator exposure-induced cerebral interleukins are modulated heterogeneously by behavioral asymmetry, Immunol. Lett., 2011, 135, 158–164[Crossref]
  • [34] Neveu P.J., Barnéoud P., Vitiello S., Betancur C., Le Moal M., Brain modulation of the immune system: association between lymphocyte responsiveness and paw preference in mice, Brain Res., 1988, 457, 392–394[Crossref]
  • [35] Quaranta A., Siniscalchi M., Frate A., Vallortigara G., Paw preference in dogs: relations between lateralised behaviour and immunity, Behav. Brain Res., 2004, 153, 521–525[Crossref]
  • [36] Tilg H., Dinarello C.A., Mier J.W., IL-6 and APPs: anti-inflammatory and immunosuppressive mediators, Immunol. Today, 1997, 18, 428–432
  • [37] Geschwind N., Behan P., Left-handedness: association with immune disease, migraine, and developmental learning disorder, Proc. Natl. Acad. Sci. USA, 1982, 79, 5097–5100[Crossref]
  • [38] Geschwind N., Galaburda A., Cerebral lateralization. Biological mechanisms, associations, and pathology: II. A hypothesis and program for research, Arch. Neurol., 1985, 42, 521–552
  • [39] Neveu P.J., Asymmetrical brain modulation of the immune response, Brain Res. Brain Res. Rev., 1992, 17, 101–107[Crossref]
  • [40] Bryden M.P., McManus I.C., Bulman-Fleming M.B., Evaluating the empirical support for the Geschwind-Behan-Galaburda model of cerebral lateralization, Brain Cogn., 1994, 26, 103–167[Crossref]
  • [41] Berenbaum S.A., Denburg S.D., Evaluating the empirical support for the role of testosterone in the Geschwind-Behan-Galaburda model of cerebral lateralization: commentary on Bryden, McManus, and Bulman-Fleming, Brain Cogn, 1995, 27, 79–83
  • [42] Grimshaw G., Bryden M., Finegan J., Relations between prenatal testosterone and cerebral lateralization in children, Neuropsychology, 1995, 9, 68–79[Crossref]
  • [43] Voracek M., Reimer B., Ertl C., Dressler S.G., Digit ratio (2D:4D), lateral preferences, and performance in fencing, Percept. Mot. Skills, 2006, 103, 427–446
  • [44] Nicholls M.E.R., Orr C.A., Yates M.J., Loftus A.M., A new means of measuring index/finger (2D:4D) ratio and its association with gender and hand preference, Laterality, 2008, 13, 71–91[Crossref]
  • [45] Manning J.T., Peters M., Digit ratio (2D:4D) and hand preference for writing in the BBC Internet Study, Laterality, 2009, 14, 528–540[Crossref]
  • [46] Stoyanov Z., Marinov M., Pashalieva I., Finger length ratio (2D:4D) in left- and right-handed males, Int. J. Neurosci., 2009, 119, 1006–1013[Crossref]
  • [47] Beaton A.A., Rudling N., Kissling C., Taurines R., Thome J., Digit ratio (2D:4D), salivary testosterone, and handedness, Laterality, 2011, 16, 136–155[Crossref]
  • [48] Chengappa K.N.R., Ganguli R., Yang Z.W., Brar J.S., Li L., Rabin B.S., Left-handed first-episode, neuroleptic-naive schizophrenic patients have a higher prevalence of autoantibodies, Schizophr. Res., 1992, 8, 75–80[Crossref]
  • [49] Chengappa K.N.R., Ganguli R., Yang Z.W., Shurin G., Cochran J., Brar J.S., et al., Non-right sidedness: an association with lower IL-2 production, Life Sci., 1992, 51, 1843–1849[Crossref]
  • [50] Lengen C., Regard M., Joller H., Landis T., Lalive P., Anomalous brain dominance and the immune system: do left-handers have specific immunological patterns?, Brain Cogn., 2009, 69, 188–193[Crossref]
  • [51] Searleman A., Fugagli A.K., Suspected autoimmune disorders and left-handedness: evidence from individuals with diabetes, Crohn’s disease and ulcerative colitis, Neuropsychologia, 1987, 25, 367–374[Crossref]
  • [52] Morris D.L., Montgomery S.M., Galloway M.L., Pounder R.E., Wakefield A.J., Inflammatory bowel disease and laterality: is left handedness a risk?, Gut, 2001, 49, 199–202[Crossref]
  • [53] Krommydas G., Gourgoulianis K.I., Andreou G., Molyvdas P.A., Left-handedness in asthmatic children, Pediatr. Allergy Immunol., 2003, 14, 234–237[Crossref]
  • [54] Preti A., Lai A., Serra M., Zurrida G.G., Mixed handedness prevails among children and adolescents with infantile asthma and diabetes, Pediatr. Allergy Immunol., 2008, 19, 769–772[Crossref]
  • [55] Bryden P.J., Bruyn J., Fletcher P., Handedness and health: an examination of the association between different handedness classifications and health disorders, Laterality, 2005, 10, 429–440[Crossref]
  • [56] Gardener H., Munger K., Chitnis T., Spiegelman D., Ascherio A., The relationship between handedness and risk of multiple sclerosis, Mult. Scler., 2009, 5, 587–592[Crossref]
  • [57] Coren S., The left-hander syndrome: the causes and consequences of left-handedness, Free Press, New York, NY, 1992
  • [58] Uslu H., Dane S., Uyanik M.H., Ayyildiz A., Relationships between intestinal parasitosis and handedness, Laterality, 2010, 15, 465–474[Crossref]
  • [59] Clavero J.M., Estevez J.P., Alvarez G., Left handedness and autoimmune diabetes mellitus, Rev. Med. Chil., 1993, 121, 903–907
  • [60] McManus I.C., Wysocki C.J., Left-handers have a lower prevalence of arthritis and ulcer, Laterality, 2005, 10, 97–102
  • [61] Betancur C., Velez A., Cabanieu G., Le Moal M., Neveu P.J., Association between left-handedness and allergy: a reappraisal, Neuropsychologia, 1990, 28, 223–227[Crossref]
  • [62] London W.P., Albrecht S.A., Breast cancer and cerebral laterality, Percept. Mot. Skills, 1991, 72, 112–114 [Crossref]
  • [63] Olsson H., Ingvar C., Left handedness is uncommon in breast cancer patients, Eur. J. Cancer, 1991, 27, 1694–1695[Crossref]
  • [64] Sandson T.A., Wen P.Y., Le May M., Reversed cerebral asymmetry in women with breast cancer, Lancet, 1992, 399, 523–524[Crossref]
  • [65] Stellman S.D., Wynder E.L., Derose D.J., Muscat J.E., The epidemiology of left-handedness in a hospital population, Ann. Epidemiol., 1997, 7, 167–171[Crossref]
  • [66] Ramadhani M.K., Elias S.G., van Noord P.A.H., Grobbee D.E., Peeters P.H., Uiterwaal C.S.P.M., Innate left handedness and risk of breast cancer: case-cohort study, BMJ, 2005, 331, 882–883[Crossref]
  • [67] Rosenkranz M.A., Jackson D.C., Dalton K.M., Dolski I., Ryff C.D., Singer B.H., et al., Affective style and in vivo immune response: neurobehavioral mechanisms, Proc. Natl. Acad. Sci. USA, 2003, 100, 11148–11152[Crossref]
  • [68] Sadock B.J., Sadock V.A., Kaplan & Sadock’s synopsis of psychiatry behavioral sciences/clinical psychiatry, 10th ed., Lippincott Williams & Wilkins, Philadelphia, PA, 2007
  • [69] Barak Y., The immune system and happiness, Autoimmun. Rev., 2006, 5, 523–527[Crossref]
  • [70] Demaree H.A., Everhart D.E., Youngstrom E.A., Harrison D.W., Brain lateralization of emotional processing: historical roots and a future incorporating “Dominance”, Behav. Cogn. Neurosci. Rev., 2005, 4, 3–20[Crossref]
  • [71] Wager T.D., Phan K.L., Liberzon I., Taylor S.F., Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging, Neuroimage, 2003, 19, 513–531[Crossref]
  • [72] Davidson R.J., Coe C.C., Dolski I., Donzella B., Individual differences in prefrontal activation asymmetry predict natural killer cell activity at rest and in response to challenge, Brain Behav. Immun., 1999, 13, 93–108[Crossref]
  • [73] Galderisi S., Mucci A., Models of human emotions: contributions from psychophysiology studies, Int. J. Psychophysiol., 1998, 30, 11[Crossref]
  • [74] Elias L.J., Saucier D.M., Guylee M.J., Handedness and depression in university students: a sex by handedness interaction, Brain Cogn., 2001, 46, 125–129[Crossref]
  • [75] Ramadhani M., Pathological left-handedness revisited: origins and later life health outcomes, PhD thesis, University of Utrecht, Utrecht, Netherlands, 2006
  • [76] Wright L., Hardie S.M., Wilson K., Handedness and behavioural inhibition: left-handed females show most inhibition as measured by BIS/BAS self-report, Pers. Individ. Dif., 2009, 46, 20–24[Crossref]
  • [77] Vartanian I.A., Stoianov Z., The role of movement asymmetry and sex in lateralization of autonomous effects, Zh. Evol. Biokhim. Fiziol., 2003, 39, 77–83, (in Russian)
  • [78] Stoyanov Z., Vartanyan I., Nikolova P., Psychophysiological reactivity and personality traits of left- and right-handers during mental stress, Fiziol. Cheloveka, 2011, 37(6), 1–4, (in press, in Russian)
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.