Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2012 | 7 | 1 | 100-107
Tytuł artykułu

Papilledema as a diagnostic challenge - report of three cases

Treść / Zawartość
Warianty tytułu
Języki publikacji
We present three different cases of patients with papilledema: one case with a primary tumour of the optic nerve, and two cases with secondary involvement of the optic nerve (breast carcinoma and non-Hodgkin lymphoma). The visual acuity varies from sudden, painless, decrease of vision, to blurred vision and proptosis on the affected eye. A characteristic ophthalmoscopic examination shows a swollen optic disc and promonence with tortuosity of blood vessels. A fluorescein angiography shows dilated capillaries of the optic disc with leakage in the early phase and diffuse hyperfluorescence during the late phase. A ultrasonography B-scan of the affected eye shows prominent optic nerves with widened optic nerve sheath. An exhaustive history and complete ophthalmological examination are essential for the diagnosis, to which fluorescein angiography, B-scan ultrasonography, ocular coherent tomography, computerized tomography, and magnetic resonance can be used as useful additional tests. Treatment and prognosis depend on the primary process. We emphasize the crucial role of ophthalmologist in the early diagnosis of CNS neoplasia.
Słowa kluczowe

Opis fizyczny
  • Department for Retinal Disorders, Eye Clinic, Clinic Centre Niš, Bulevar Dr Zorana Đinđića 48, 18000, Niš, Serbia,
  • Department for Retinal Disorders, Institute for Eye Diseases, Faculty of Medicine, Dr Subotića 8 Street, 11 000, Belgrade, Serbia
  • Eye Clinic, Faculty of Medicine, University of Niš, Bulevar Dr Zorana Đinđića 48, 18000, Niš, Serbia
  • Centar for Radiology, Clinic Centre Niš, Bulevar Dr Zorana Đinđića 48, 18000, Niš, Serbia
  • Department of Ophthalmology, Faculty of Medicine, Kosovska Mitrovica, Serbia
  • Department of Anatomy, Faculty of Medicine, University of Niš, Bulevar Dr Zorana Đinđića 81, 18000, Niš, Serbia
  • Eye Clinic, Faculty of Medicine, University of Niš, Bulevar Dr Zorana Đinđića 48, 18000, Niš, Serbia
  • [1] Fischer N, Stuermer J, Rodic B, Pless M. Carboplatin-Induced Bilateral Papilledema: A Case Report. Case Rep Oncol 2009;2:67–71[Crossref]
  • [2] Cekić S, Stanković Babić G, Višnjić Z, Jovanović I, Risimić D. Optic disc abnomalities-diagnosis, evolution, and influence on visual acuity. Bosn. J Basic Med Sci. 2010;10(2): 125–132
  • [3] Wilhelm H. Primary optic nerve tumours. Curr Opin Neurol. 2009;22(1):11–18[Crossref][WoS]
  • [4] Cekić S, Stanković Babić G. Application of ultrasound in diagnosing and follow-up of endocrine orbitopathy. Med Pregl. 2010;63(3–4):241–248 [Crossref][PubMed]
  • [5] Sibony PA, Krauss HR, Kennerdell JS, Maroon JC, Slamovits TL. Optic nerve sheath meningioma: clinical manifestations. Ophthalmol. 1984;91:1313–1324
  • [6] Higashida T, Sakata T, Kanno H, Kawasaki T, Tanabe Y, Yamamoto I. Hemangioblastoma of the Optic Nerve-case report. Neurol Med Chir. 2007; 47:215–218[Crossref]
  • [7] Mayo GL, Carter JE, McKinnon SJ. Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia. Am J Ophthalmol 2002; 134:141–142.[Crossref]
  • [8] Lin YC, Wang AG, Yen MY, Hsu WM. Leukaemic infiltration of the optic nerve as the initial manifestation of leukaemic relapse. Eye 2004; 18:546–550[Crossref]
  • [9] Levy-Clarke GA, Greenman D, Sieving PC, Byrnes G, Shen D, Nussenblatt R, Chan CC. Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma Report of a case and review of the literature. Surv Ophthalmol. 2008;53:546–555[Crossref][WoS]
  • [10] Gill MK, Jampol LM. Variations in the presentation of primary intraocular lymphoma Case reports and a review. Surv Ophthalmol. 2001;45:463–471[Crossref]
  • [11] Castro-Rebollo M, Vleming EN, Drake-Rodríguez P, Benítez-Herreros J, Pérez-Rico C. Primary cerebral lymphoma diagnosed by the ophthalmologist. Arch Soc Esp Oflalmol 2010;85(1):35–37
  • [12] Tatsugawa M, Noma H, Mimura T, Funatsu H. Unusual orbital lymphoma undetectable by magnetic resonance imaging: a case report. J Med Case Reports 2009,3:104[Crossref]
  • [13] Moll A, Niwald A, Gratek M, Stolarska M. Ocular complications in leukaemias and malignant lymphomas in children. Klin Oczna. 2004;106:783–787 [PubMed]
  • [14] Balajia R, Ramachandrana K, Kumarb A, Krishnakumara AS, Venugopala M. Pachymeningeal metastasis from squamous cell carcinoma of the uterine cervix with involvement of the optic nerve: case report and review of the literature. Cancer Imaging. 2007;7:138–140[Crossref]
  • [15] Dutton JJ. Optic nerve sheath meningioma. Surv Ophthalmol. 1992;37:167–183[Crossref]
  • [16] Chamberlain MC. Meningiomas. Curr Treat Options Neurol. 2001;3:67–76[Crossref]
  • [17] Turbin RE, Pokorny K. Diagnosis and treatment of orbital optic nerve sheath meningioma. Can Control. 2004;11:334–341 [PubMed]
  • [18] Guthoff R, Thijssen JM. Ultrasound in ophthalmologic diagnosis: A practical guide. G. Thieme Verlag, Stuttgart, 1991
  • [19] Turbin RE, Thompson CR, Kennerdell JS, Cockerham KP, Kupersmith MJ. A long-term visual outcome comparison in patients with optic nerve sheath meningioma managed with observation, surgery, radiotherapy, or surgery and radiotherapy. Ophthalmol. 2002;109:890–899[Crossref]
  • [20] Jeremić B, Pitz S. Primary Optic Nerve Sheath Meningioma Stereotactic Fractionated Radiation Therapy as an Emerging of Choice. Cancer. 2007;110:714–722[Crossref]
  • [21] Shibata K, Shimamoto Y, Nishimura T, Okinami S, Yamada H, Miyahara M. Ocular manifestations in adult T-cell leukaemia/lymphoma. Ann Hematol. 1997;74:163–168[Crossref]
  • [22] Omoti AE, Omoti CE. Ophthalmic manifestations of lymphoma. Ann Afr Med. 2007;6:89–93[Crossref]
  • [23] Mennel RG. Ocular Metastases from Breast. Can Clin Breast Can. 2001;4:318–319[Crossref]
  • [24] Noy A. Update in lymphoma. Curr Opin Oncol. 2006;18:449–455[Crossref]
  • [25] Pache M, Kain H, Buess M, Flammer J, Meyer P. Primary intraocular lymphoma with unusual clinical presentation and poor outcome. Klin Monatsbl Augenheilkd. 2004;221:401–403[Crossref]
  • [26] De Angelis LM, Yahamol J, Thaler HT, Kher U. Combined Modality Therapy For Primary CNS Lymphomas. J Clin Oncol. 1992;10:635–642
  • [27] Coutinho AB, Muccioli C, Martins MC, Belfort R, Jr, Sant’Anna AE, Burnier MN, Jr. Extranodal B-cell lymphoma of the uvea A case report. Can J Ophthalmol. 2005;40:623–626 [Crossref][PubMed]
  • [28] Forte R, Cennamo G, Breve MA. Three-Dimensional Ultrasound of Ophthalmic Pathologies. Ophthalmologica. 2009;223(3):183–187[Crossref][WoS]
  • [29] Chan CC, Buggage RR, Nussenblatt RB. Intraocular lymphoma. Curr Opin Ophthalmol. 2002;13:411–418[Crossref]
  • [30] Savini G, Bellusci C, Carbonelli M et al. Detection and Quantification of Retinal Nerve Fiber Layer Thickness in Optic Disc Edema Using Stratus OCT. Arch Ophthalmol. 2006;124:1111–1117[Crossref]
  • [31] Johnsn LD, Diehl ML, Hamm CD, Somerville DN, Petroski DG. Differentiating Optic Disc Edema From Optic Nerve Head Drusen on Optical Coherence Tomography. Arch Ophthalmol.2009;127:45–49[Crossref]
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.