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2011 | 6 | 6 | 773-777
Tytuł artykułu

A case of almagel-induced methemoglobinemia after pancreatoduodenal resection

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We are reporting the case of severe methemoglobinemia resulting from Almagel which was given for treatment of gastrointestinal ulcers after pancreatoduodenal resection. A 64 year old man was treated with Almagel A postoperatively. One day after treatment began, the patient reported what appeared to be cyanotic discolorations of his lips and fingers. (SpO2 80%, normal pO2). Two days later, the patient was diagnosed with methemoglobinemia via co-oximetry and treated with methylene blue. The causes of methemoglobinemia remained unclear, and Almagel A was reinitiated until the second episode of methemoglobinemia, was diagnosed and treated promptly. The dose of benzocaine in Almagel A (100 mg/5 ml) was sufficient enough to cause methemoglobinemia, confirmed using multiwavelength co-oximeter and successfully treated with methylene blue.
Wydawca
Czasopismo
Rocznik
Tom
6
Numer
6
Strony
773-777
Opis fizyczny
Daty
wydano
2011-12-01
online
2011-10-08
Twórcy
  • Department of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, LT 50009, Kaunas, Lithuania
  • Department of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, LT 50009, Kaunas, Lithuania
  • Department of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, LT 50009, Kaunas, Lithuania
  • Department of Anaesthesiology, Medical Academy, Lithuanian University of Health Sciences, LT 50009, Kaunas, Lithuania
  • Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, LT 50009, Kaunas, Lithuania
Bibliografia
  • [1] Dahshan A, Donovan GK, Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature, Pediatrics, 2006; 117(4): e806–809 http://dx.doi.org/10.1542/peds.2005-1952[Crossref]
  • [2] Moore TJ, Walsh CS, Cohen MR, Reported adverse event cases of methemoglobinemia associated with benzocaine products, Arch Intern Med, 2004; 164(11): 1192–1196 http://dx.doi.org/10.1001/archinte.164.11.1192[Crossref]
  • [3] Throm MJ, Stevens MD, Hansen C, Benzocaine-induced methemoglobinemia in two patients: interdisciplinary collaboration, management, and near misses, Pharmacotherapy, 2007; 27(8): 1206–1214 http://dx.doi.org/10.1592/phco.27.8.1206[WoS][Crossref]
  • [4] Package leaflet of Almagel A, available in http://www.actavis.bg/NR/rdonlyres/7E4CAD8D-AD13-4EE6-BAD9-6F680C78F761/0/ALMAGELA_ENG.pdf, accessed February 28, 2011
  • [5] Guay J, Methemoglobinemia related to local anesthetics: a summary of 242 episodes, Anesth Analg, 2009; 108: 837–845 http://dx.doi.org/10.1213/ane.0b013e318187c4b1[WoS]
  • [6] Umbreit J, Methemoglobin-it’s not just blue: a concise review, Am J Hematol, 2007; 82(2): 134–144 http://dx.doi.org/10.1002/ajh.20738[WoS][Crossref]
  • [7] Titov VY, Petrenko YM, Proposed mechanism of nitrite induced methemoglobinemia, Biochemistry (Mosc), 2005; 70: 473–483 http://dx.doi.org/10.1007/s10541-005-0139-7[Crossref]
  • [8] Griffin JP, Methemoglobinemia, 1997; 16: 45–63 [PubMed]
  • [9] McLean S, Murphy BP, Starmer GA, Thomas J, Methemoglobin formation induced by aromatic amines and amides. J Pharm Pharmacol 1967; 19: 146–154 http://dx.doi.org/10.1111/j.2042-7158.1967.tb08056.x[Crossref]
  • [10] Paparella S, Valley H, Topical anesthetic sprays directly associated with a serious, sometimes fatal drug reaction: methemoglobinemia, J Emerg Nurs 2005; 31(5): 468–469 http://dx.doi.org/10.1016/j.jen.2005.06.024[Crossref]
  • [11] Moos DD, Cuddeford JD, Methemoglobinemia and benzocaine, Gastroenterol Nurs 2007; 30(5): 342–345, quiz 346–347 http://dx.doi.org/10.1097/01.SGA.0000296253.78457.f4[Crossref][WoS]
  • [12] Novaro GM, Aronow HD, Militello MA, Garcia MJ, Sabik EM, Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory, J Am Soc Echocardiogr 2003; 16: 170–175 http://dx.doi.org/10.1067/mje.2003.5[Crossref]
  • [13] Khorasani A, Candido KD, Ghaleb AH, Saatee S, Appavu SK, Canister tip orientation and residual volume have significant impact on the dose of benzocaine delivered by Hurricane spray, Anesth Analg 2001; 92: 379–383 http://dx.doi.org/10.1213/00000539-200102000-00019[Crossref]
  • [14] Weinberg GL, Banning benzocaine: of bananas, bureaucrats, and blue men. Anesth Analg 2009; 108(3): 699–701 http://dx.doi.org/10.1213/ane.0b013e318196ac09[WoS][Crossref]
  • [15] Institute for Safe Medication Practices, Benzocaine-containing topical sprays and methemoglobinemia, ISMP Medication Safety Alert! 2002; 7: 1–2
  • [16] Gupta PM, Lala DS, Arsura EL, Benzocaine-induced methemoglobinemia, South Med J 2000; 93(1): 83–86 [PubMed][Crossref]
  • [17] Ash-Bernal R, Wise R, Wright SM, Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. Medicine (Baltimore), 2004; 83(5): 265–273
  • [18] Barker SJ, Badal JJ, The measurement of dyshemoglobins and total hemoglobin by pulse oximetry, Curr Opin Anaesthesiol 2008; 21: 805–810 http://dx.doi.org/10.1097/ACO.0b013e328316bb6f[WoS][Crossref]
  • [19] Abdallah HY, Shah SA, Methemoglobinemia induced by topical benzocaine: a warning for the endoscopist. Endoscopy 2002; 34: 730–734 http://dx.doi.org/10.1055/s-2002-33450[Crossref]
  • [20] Samsygina GA, Brashnina NP, Methemoglobinemia in newborn infants after using almagel, Gematol Transfuziol, 1989; 34(11): 57–59 [PubMed]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0100-7
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