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2011 | 6 | 6 | 691-695
Tytuł artykułu

“Serum and follicular LH, pregnancy prediction and assisted reproduction”

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of this study was to determine the mean serum and follicular fluid LH and estradiol values in patients treated by IVF/ET (ICSI) after completed ovarian stimulation and to determine the range of values for these hormones with higher chances of conceiving pregnancies. All patients underwent stimulation in long agonistic protocol. Collected samples of body fluids (serum n = 31, follicular fluid n = 93) were centrifuged and supernatant was separated, aliquoted, frozen and stored at − 20°C. LH and E2 were measured in serum and follicular fluids. Cutoff value of E2 determined using follicular LH and follicular E2 correlation was 2100 nmol/L. If the E2 value was lower than 2100 nmol/L the ratio of results related to pregnancy was 29,4% (15/51). If the follicular E2 values were higher than 2100 nmol/L the ratio of results related to pregnancy was (7,1%, 3/42). The observed differences were significant (p 0.03). Follicular LH values higher than 3.1 IU/L and follicular E2 values < than 2100 nmol/L indicate higher conceiving probability. Our results can be fit in previous findings on negative effects of low LH values in IVF treatment procedures.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
6
Numer
6
Strony
691-695
Opis fizyczny
Daty
wydano
2011-12-01
online
2011-10-08
Twórcy
  • Department for Gynecology and Obstetrics, Clinical Hospital Rijeka, School of Medicine, University of Rijeka, 51000, Rijeka, Croatia , nedas@medri.hr
  • Department for Gynecology and Obstetrics, Clinical Hospital Rijeka, School of Medicine, University of Rijeka, 51000, Rijeka, Croatia
autor
  • Department for Gynecology and Obstetrics, Clinical Hospital Rijeka, School of Medicine, University of Rijeka, 51000, Rijeka, Croatia
  • Department for Gynecology and Obstetrics, Clinical Hospital Rijeka, School of Medicine, University of Rijeka, 51000, Rijeka, Croatia
Bibliografia
  • [1] Smitz J, Andersen N A, Devroey P and Arce J C for the MERIT* Group: Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients. Hum Repr 2006; 16:1–12
  • [2] Mendoza C, Ruiz-Requena E, Ortega E, Cremades N, Martinez F, Bernabeu R, Greco E and Tesarik J: Follicular fluid markers of oocyte developmental potential. Hum Reprod 2002; 17;1017–1022 http://dx.doi.org/10.1093/humrep/17.4.1017[Crossref]
  • [3] Murray A A, Swales A K E, Smith R E, Molinek M D, Hillier S G and Spears N: Follicular growth and oocyte competence in the in vitro cultured mouse follicle: effects of gonadotrophins and steroids. MHR-Basic Science of Reproductive Medicine 2008;14,2: 75–83
  • [4] Anahory T, Dechaud H, Bennes R, Marin P, Lamb N J and Laoudj D: Identification of new proteins in follicular fluid of mature human follicles. Electrophoresis 2002; 23:1197–1202 http://dx.doi.org/10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2[Crossref]
  • [5] Hillier S G: Gonadotropic control of ovarian follicular growth and development. Mol Cell Endocrinol 2001;179:39–46 http://dx.doi.org/10.1016/S0303-7207(01)00469-5[Crossref]
  • [6] Hild-Petito S, West N B, Brenner R M, Stouffer R L: Localization of androgen receptor in the follicle and corpus luteum of the primate ovary during the menstrual cycle. Biol Reprod 1991;44:561–568 http://dx.doi.org/10.1095/biolreprod44.3.561[Crossref]
  • [7] Murray A A, Gosden R G, Allison V, Spears N: Effect of androgens on the development of mouse follicles growing in vitro. J Reprod Fertil 1998;113:27–33 http://dx.doi.org/10.1530/jrf.0.1130027[Crossref]
  • [8] Xia P, Younglai E V: Relationship between steroid concentrations in ovarian follicular fluid and oocyte morphology in patients undergoing intracytoplasmic sperm injection (ICSI) treatment. J Reprod Fertil 2000;118:229–233 http://dx.doi.org/10.1530/reprod/118.2.229[Crossref]
  • [9] Westergaard L G, Laursen S B, Andersen C Y: Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotrophic women undergoing assisted reproduction. Hum Reprod 2000; 5:1003–1008 http://dx.doi.org/10.1093/humrep/15.5.1003[Crossref]
  • [10] Fleming R, Rehka P, Deshpande N, Jamieson M E, Yates R W, Lyall H: Suppression of LH during ovarian stimulation: effects differ in cycles stimulated with purified urinary FSH and recombinant FSH. Hum Reprod 2000; 15:1440–1445 http://dx.doi.org/10.1093/humrep/15.7.1440[Crossref]
  • [11] Balasch, J and FaÂbregues, F: Is luteinizing hormone needed for optimal ovulation induction? Curr. Opin. Obstet. Gynecol. 2002; 14; 265–274 http://dx.doi.org/10.1097/00001703-200206000-00004[Crossref]
  • [12] Penarrubia J, Fabregues F, Creus M, Manau D, Casamitjana R, Guimera M, Carmona F, Vanrell J A, Balasch J: LH serum levels during ovarian stimulation as predictors of ovarian response and assisted reproduction outcome in down-regulated women stimulated with recombinant FSH. Hum Reprod 2003;18:2689–2697 http://dx.doi.org/10.1093/humrep/deg506[Crossref]
  • [13] Kolibianakis E M, Zikopoulos K, Schiettecatte J, Smitz J, Tournaye H, Camus M, Van Steirteghem A C, Devroey P: Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF. Hum Reprod 2004;19:2490–2496 http://dx.doi.org/10.1093/humrep/deh471[Crossref]
  • [14] Merviel P, Antoine J M, Mathieu E, Millot F, Mandelbaum J, Uzan S: Luteinizing hormone concentrations after gonadotropinreleasing hormone antagonist administration do not influence pregnancy rates in in vitro fertilization-embryo transfer. Fertil Steril 2004:82:119–125 http://dx.doi.org/10.1016/j.fertnstert.2003.11.040[Crossref]
  • [15] Cabrera RA, Stadtmauer L, Mayer JF, Gibbons WE, Oehninger S: Follicular phase serum levels ofluteinizing hormone do not influence delivery rates in in vitro fertilization cycles down-regulated with a gonadotropin-releasing hormone agonist and stimulated with recombinant follicle-stimulating hormone. Fertil Steril 2005:83:42–48 http://dx.doi.org/10.1016/j.fertnstert.2004.06.050[Crossref]
  • [16] Fleming R, Rehka, P, Deshpande, N, Jamieson, M E, Yates, RWS and Lyall, H: Suppression of LH during ovarian stimulation: effects differ in cycles stimulated with purified urinary FSH and recombinant FSH. Hum. Reprod. 2000; 15: 1440–1445. http://dx.doi.org/10.1093/humrep/15.7.1440[Crossref]
  • [17] Lam PM, Cheung L P, Choy CMY, Lau YP and Haines C: Effects of the intensity of downregulation on outcome of in vitro fertilization and embryo transfer. Gynecol. Endocrinol. 2002: 16: 143–150
  • [18] Shoham Z: The clinical therapeutic window for luteinizing hormone in controlled ovarian stimulation. Fertil Steril 2002; 77:1170–1177 http://dx.doi.org/10.1016/S0015-0282(02)03157-6[Crossref]
  • [19] Al Inany H: Differential dose of antagonist (Ganirelix) relative to exogenous FSH. Fertil Steril 2001; 76:1080 http://dx.doi.org/10.1016/S0015-0282(01)02847-3[Crossref]
  • [20] Loumaye E, Engrand P, Shoham Z, Hillier S G, Baird D T: Clinical evidence for an LH ceiling? Hum Reprod 2003;18:2719–2720. http://dx.doi.org/10.1093/humrep/deg493[Crossref]
  • [21] Mendoza C, Cremades N, Ruiz-Requena E, Martinez F, Ortega E, Bernabeu S and Tesarik J: Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrations. Hum Reprod 1999;14,3:628–635 http://dx.doi.org/10.1093/humrep/14.3.628[Crossref]
  • [22] Filicori M and Cognini G: Roles and Novel Regimens of Luteinizing Hormone and Follicle-Stimulating Hormone in Ovulation Induction. The Journal of Clinical Endocrinology & Metabolism 2001; 86,.4:1437–1441 http://dx.doi.org/10.1210/jc.86.4.1437[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0083-4
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