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2011 | 6 | 5 | 527-536
Tytuł artykułu

Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Paclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
6
Numer
5
Strony
527-536
Opis fizyczny
Daty
wydano
2011-10-01
online
2011-08-09
Twórcy
  • Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia , ici.teh@gmail.com
autor
  • Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia
autor
  • Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia
  • Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Serbia
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0074-5
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