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2011 | 6 | 5 | 616-624
Tytuł artykułu

Genome-wide linkage scan of major depressive disorder in two Dagestan genetic isolates

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We conducted a 10-cM genome-wide linkage scan in two extended pedigrees, ascertained from two diverse Dagestan genetic isolates with high aggregation of major depressive disorder (MDD) and suicides. Using genome wide multipoint parametric linkage analyses with short tandem repeat markers, we found two previously undetected genomic regions with significant linkage in isolate #6007 with LODs=3.1–3.4 at 2p13.2–p11.2 (and some signal in same region for #6008) and in 14q31.12–q32.13. We also obtained suggestive evidence for linkage with MDD at 9q33.3–q34.2 (#6008), 13q31.1–q31.2(#6007), 11p15(#6008), 17q25.3(#6007) and 19q13.31–q13.33 (#6008). Five regions (1p36.1–p35.2, 2p13.2–p11.2, 17q25.3, 18q22 and 22q12.3) demonstrated at least nominal linkage in both isolates’ pedigrees, while all other linkage regions demonstrated population-specific genetic heterogeneity.

Opis fizyczny
  • N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia,
  • Division of Psychiatry Research, The Zucker Hillside Hospital, New York, NY, 11004, USA
  • Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA
  • Hiroshima University, Kasumi 1-2-3, Hiroshima, 734-8553, Japan
  • N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia
  • N.I.Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia
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