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2011 | 6 | 4 | 395-399
Tytuł artykułu

Surgical treatment of gastrointestinal autonomic nerve tumors (GANT) in children-2 case reports

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Gastrointestinal autonomic nerve tumors form an uncommon subcategory of stromal tumors of the intestinal tract although their histologic appearance is similar to other gastrointestinal stromal tumors. Our aim was to evaluate our experience in the diagnosis and therapy of these kinds of tumors. Two patients were admitted to the Pediatric Surgery Clinic in Niš with abdominal pain and a palpable mass in the abdomen. After excision, the tumor tissue was sampled, sent for histopathological diagnosis, and examined by light microscopy, immunohistochemistry, and electron microscopy. Postoperatively, both patients recovered without complications. The patient with the tumor bulk in the mesentery of the small bowel had no evidence of tumor progression 6 years after surgery. In the second case, a giant tumor was present along the greater curvature of gaster. Even with a tumor of this size, there were no signs of progression 10 years after surgery. Radical surgical resection of gastrointestinal autonomic nerve tumors seems to be the curative approach to date, and long-term survival is possible even with large tumors.
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
4
Strony
395-399
Opis fizyczny
Daty
wydano
2011-08-01
online
2011-06-01
Twórcy
  • Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia
  • Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia
  • Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia
  • Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia, ivonadj74@gmail.com
autor
  • Institute of Pathology, Clinical Center Nis, 18000, Nis, Republic of Serbia
Bibliografia
  • [1] Herrera GA, Pinto De Moraes H, Grizzle WE, Han SG. Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma). Light and electron microscopic study confirming the origin of the neoplasm. Dig Dis Sci 1984;29:275–284 http://dx.doi.org/10.1007/BF01296263[Crossref]
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  • [4] Shek TW, Luk IS, Loong F, Ip P, Ma L. Inflammatory cell-rich gastrointestinal autonomic nerve tumor. An expansion of its histologic spectrum. Am J Surg Pathol 1996; 20: 325–331 http://dx.doi.org/10.1097/00000478-199603000-00009[Crossref]
  • [5] Reid I, Suvarna SK, Wagner BE, Rogers K. Plexosarcoma of the bladder. Eur J Surg Oncol 1997; 23: 463–465 http://dx.doi.org/10.1016/S0748-7983(97)93737-9[Crossref]
  • [6] Donner LR. Gastrointestinal autonomic nerve tumor: a common type of gastrointestinal stromal neoplasm. Ultrastruct. Pathol 1997; 21: 419–424 http://dx.doi.org/10.3109/01913129709021940[Crossref]
  • [7] Erlandson RA, Klimstra DS, Woodruff JM. Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry. Ultrastruct Pathol 1996; 20: 373–393 http://dx.doi.org/10.3109/01913129609016340[Crossref]
  • [8] Lev D, Kariv Y, Messer GY, Isakov J, Gutman M. Gastrointestinal autonomic nerve (GAN) tumor of the rectum. J Clin Gastroenterol 2000; 30: 438–440 http://dx.doi.org/10.1097/00004836-200006000-00018[Crossref]
  • [9] Shek TWH, Luk ISC, Loong F, Ip P, Ma L. Inflammatory cellrich gastrointestinal autonomic nerve tumor: an expansion of its histologic spectrum. Am J Surg Pathol 2003;20:325–331 http://dx.doi.org/10.1097/00000478-199603000-00009[Crossref]
  • [10] Hellies R, Sulis R, Puliga A, Pala M, Pietrangeli M. GIST: surgical treatment of34 cases. Tumori 2003;89(4 Suppl): 133–134
  • [11] Bucher P, Villiger P, Egger.IF, Bubier LI-I, Morel P. Management of gastrointestinal stromal tumors: from diagnosis to treatment. Swiss Med Wkly 2004;134(11–12):145–153
  • [12] Lee JR, Joshi V, Griffin JW Jr, Lasota J, Miettinen M. Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumor. Am J Surg Pathol 2001; 25: 979–987 http://dx.doi.org/10.1097/00000478-200108000-00001[Crossref]
  • [13] Kerr JZ, Hicks MJ, Nuchtern GJ, Saldivar V, Hall JH, Shah S et al. Gastrointestinal Autonomic Nerve Tumors in the Pediatric Population. A Report of Four Cases and a Review of the Literature. Cancer January 1999; 85(1): 220–230
  • [14] Lauwers GY, Erlandson RA, Casper ES, Brennan MF, Woodruff M. Gastrointestinal autonomic nerve tumors. A clinicopathological,immunohistochemica l, and ultrastructural study of 12 cases. Am J Surg Pathol 1993; 17:887–897 http://dx.doi.org/10.1097/00000478-199309000-00004[Crossref]
  • [15] Joensuu H, Fletcher C, Dimitrijevic S, Silberman S, Roberts P, Demetri G. Management of malignant gastrointestinal stromal tumours. Lancet Oncol 2002; 3: 655–664 http://dx.doi.org/10.1016/S1470-2045(02)00899-9[Crossref]
  • [16] Bucher P, Villiger P, Egger.IF, Bubier LI-I, Morel P. Management of gastrointestinal stromal tumors: from diagnosis to treatment. Swiss Med Wkly 2004;134(11–12):145–153
  • [17] Hellies R, Sulis R, Puliga A, Pala M, Pietrangeli M. GIST: surgical treatment of34 cases. Tumori 2003;89(4 Suppl): 133–134
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-011-0030-4
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