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2011 | 6 | 1 | 31-36
Tytuł artykułu

Kinetic of monocytes Fcγ receptors in patients after coronary artery bypass

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Cardiopulmonary bypass is usually associated with an increased risk of post-operative infections and systemic inflammatory response syndrome. This is accompanied by a neutrophil leucocytosis and lymphopenia. Less is known about the role of monocytes and markers of monocyte activity. This study focuses on the changes of Fc-gamma receptors on monocytes in patients undergoing on-pump coronary artery bypass grafting (CABG).The surface expression of CD64, CD32 and CD16 were studied using flow cytometry in 37 patients scheduled for CABG. The antigen density and the percentage positive cells were monitored preoperatively and on day 1, 2, 3 and 7 postoperatively. CD64 and CD32 antigen density were significantly increased from day 1 to day 7(p<0.0001). A significant increase (p<0.0001) in the percentage CD16+ monocytes was detected at day 1,2,and 3. The downregulation of CD16 expression on day 1 was followed be elevation at days 2,3(p<0.01). On day 7th percentage CD16+ monocytes and density were not returned to baseline values. Only the baseline levels of CD64 was lower compared to controls(p<0.05). The results suggest that on-pump CABG induces dynamic changes in the expression of Fc-gamma receptors on monocytes as late as 7 days. We observed significant upregulation in the expression of CD64 and CD32 and “to phases” distribution of CD16 in the post-CABG period.
Wydawca
Czasopismo
Rocznik
Tom
6
Numer
1
Strony
31-36
Opis fizyczny
Daty
wydano
2011-02-01
online
2010-12-16
Twórcy
  • Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Jonas Lies V. 65, 5021, Bergen, Norway , hrandreeva@yahoo.com
  • Department of Woman and Child Health, Karolinska Institute, 171 77, Stockholm, Sweden
Bibliografia
  • [1] Hall RI, Smith MS, Rocker G. The systemic inflammatory response to cardiopulmonary bypass: pathophysiological, therapeutic, and pharmacological considerations. Anesth Analg, 1997, 85, 766–782 http://dx.doi.org/10.1097/00000539-199710000-00011[Crossref]
  • [2] Dybdahal B, Wahba A, Haaverstad R, Kirkeby-Garstad I, Kierulf P, Espevik T. et al. On-pump versus off-pump coronary artery bypass grafting: more heat. shock protein 70 is released after on-pump surgery. Eur J Cardiothorac Surg, 2004, 25, 985–992 http://dx.doi.org/10.1016/j.ejcts.2004.03.002[Crossref]
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  • [5] Kolachkova M, Kudlova M, Kunes P, Lonsky P, Mandak J, Andrys C., et al. Early Expression of FcγRI (CD64) on monocytes of cardiac surgical patients and higher density of monocytes anti-inflammatory scavenger CD163 receptor in “on-pump” patients. Mediators of Inflammation, 2008, 1–6 [WoS][Crossref]
  • [6] Stefanou DC, Asimakopoulos G, Yagnik DR, Haskard DO, Anderson JR, Philippidis P., et al. Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting. Ann Thorac Surg, 2004, 77, 951–955 http://dx.doi.org/10.1016/j.athoracsur.2003.09.026[Crossref]
  • [7] Hiesmayr MJ, Spittler A, Lassnigg A, Berger R, Laufer G, Kocher A., et al. Alterations in the number of circulating leucocytes, phenotype of monocyte and cytokine production in patients undergoing cardiothoracic surgery. Clin Exp Immunol, 1999, 115, 15–323 http://dx.doi.org/10.1046/j.1365-2249.1999.00801.x[Crossref]
  • [8] Fjaertoft G, Hakansson LD, Pauksens K, Sisask G, Venge P. Neutrophil CD64 (FcγRI) expression is a specific marker of bacterial infection: A study on the kinetics and the impact of major surgery. Scand J Infect Dis, 2007, 39, 525–535 http://dx.doi.org/10.1080/00365540601113693[Crossref]
  • [9] Parolari A, Camera M, Alamanni F, Naliato M, Polvani GL, Agrifoglio M, et al. Systemic inflammation after on-pump and off-pump coronary bypass surgery: a one-month follow-up. Ann Thorac Surg, 2007, 84, 823–828 http://dx.doi.org/10.1016/j.athoracsur.2007.04.048[Crossref]
  • [10] Devaraj S, Yun JM, Duncan-Staley C, Jialal I. C-reactive protein induces M-CSF release and macrophage proliferation. J Leukoc Biol, 2008, 13, 1–6
  • [11] Quereshi SS, Lewis SM, Gant VA, Treacher D, Davis BH, Brown KA. Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the SIRS. Clin&Exp Immunol, 2001, 125, 258–265
  • [12] Heijnen IAFM, van de Winkel JGJ. Human IgG Fc receptors. Int Rev Immunol, 1997, 16, 29–55 http://dx.doi.org/10.3109/08830189709045702[Crossref]
  • [13] Devaraj S, Dasu MR, Singhu U, Rao V, Jialal I. CRP stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis, 2009, 203, 67–74 http://dx.doi.org/10.1016/j.atherosclerosis.2008.05.060[Crossref][WoS]
  • [14] Fingerle-Rowson G, Auers J, Kreuzer E. et al. Expansion of CD14+/CD16+ monocytes in critically ill cardiac surgery patients. Inflammation, 1998, 22, 367–379 http://dx.doi.org/10.1023/A:1022316815196[Crossref]
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  • [16] Tsuchida M, Watanabe H, Watanabe T, Hirahara H, Haga M, Ohzeki H. et al. Effect of cardiopulmonary bypass on cytokine release and adhesion molecule expression in alveolar macrophages. Preliminary report in six cases. Am J Resp Crit Care Med, 1997, 156, 932–938
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0056-z
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