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Czasopismo
2011 | 6 | 1 | 58-63
Tytuł artykułu

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Although, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the mechanism of its toxicity on extracardiac tissues is still poorly understood. Several antioxidants have been shown to prevent AMD-induced toxicity by antioxidant and/or non-antioxidant mechanisms. In the current study, we evaluated the possible protective effect, in vitro, of vitamin C on AMD-induced toxicity in rat thymocytes. Rat thymocytes were cultured with increasing AMD concentrations (1–20 μM) with or without vitamin C (1000 μg/ml), for 24 hours. Cells treatment with AMD resulted in a concentration-dependent increase of hypodiploid cells and a significant decrease in cellular glutathione content. Vitamin C combined with AMD significantly decreased the proportion of hypodiploid cells and markedly increased the cellular glutathione content, compared with AMD treatment alone. These results suggest that treatment with vitamin C may prevent AMD-induced toxicity in rat thymocytes by restoring cellular glutathione content.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
1
Strony
58-63
Opis fizyczny
Daty
wydano
2011-02-01
online
2010-12-16
Twórcy
autor
  • Institute of Physiology, Medical Faculty University in Nis, 18000, Nis, Serbia
autor
  • Institute of Biochemistry, Medical Faculty University in Nis, 18000, Nis, Serbia
autor
  • Medical Faculty University in Nis, 18000, Nis, Serbia
autor
  • Clinic of Pediatrics, Medical Faculty University in Nis, 18000, Nis, Serbia
autor
  • Institute for Prevention, Treatment and Rehabilitation of Rheumatic and Cardiovascular Diseases, Medical Faculty University in Nis, 18000, Nis, Serbia
autor
  • Institute of Physiology, Medical Faculty University in Nis, 18000, Nis, Serbia, vojapav@yahoo.com
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0050-5
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