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2010 | 5 | 6 | 752-757
Tytuł artykułu

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.
Wydawca

Czasopismo
Rocznik
Tom
5
Numer
6
Strony
752-757
Opis fizyczny
Daty
wydano
2010-12-01
online
2010-10-07
Twórcy
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia, aldaghri2000@hotmail.com
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia
  • Clinical Pharmacy Department, College of Pharmacy, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia
  • Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia
  • Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia
  • College of Applied Medical Sciences, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia
  • King Abdulaziz Medical City, 11426, Riyadh, Kingdom of Saudi Arabia
autor
  • Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0045-2
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