Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
Sepsis remains a serious clinical problems resulting in high morbidity and mortality. We aimed to investigate the inflammatory response in a septic rat model treated with immunomodulator agents. We used the cecal ligature and puncture model to establish septic peritonitis in rats. Male Wistar-Albino rats were randomized into groups of seven rats each and assigned different regimens: Tacrolimus 1 mg/kg/day, cyclosporin-A 5 mg/kg/day and methylprednisolone 15 mg/kg/day. These immunsuppressive agents were applied at the 6 and 48 hour intraperitoneally. The animals were euthanized after 6 and 48 hours and systemic parameters including, IL-2, IL-6, TNF-a, CRP, AST and creatinine were examined. Our study demonstrated that the experimental peritonitis model caused a meaningful rise in the values of systemic parameters. This was especially apparent for early-applied cyclosporin A; in addition, tacrolimus significantly decreased the levels both at the 6 and 48 hour. The excess immune response in complex sepsis treatment might be restrained using immunosuppressive agents administered early. Although additional supportive, comprehensive, experimental and clinical studies are still needed, this therapy model may prove to be an alternative for the future.
Czasopismo
Rocznik
Tom
Numer
Strony
683-690
Opis fizyczny
Daty
wydano
2010-12-01
online
2010-10-07
Twórcy
autor
- Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of General Surgery, 34668, Uskudar, Istanbul, Turkey, dralifiliz@yahoo.com
autor
- Department of General Surgery, Corlu Military Hospital, 59850, Corlu, Tekirdag, Turkey
autor
- Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of General Surgery, 34668, Uskudar, Istanbul, Turkey
autor
- Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of General Surgery, 34668, Uskudar, Istanbul, Turkey
autor
- Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of General Surgery, 34668, Uskudar, Istanbul, Turkey
autor
- Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of General Surgery, 34668, Uskudar, Istanbul, Turkey
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-010-0027-4