PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2010 | 5 | 3 | 347-353
Tytuł artykułu

Herbal remedies are the main etiologic factor in melanosis coli, a case series study

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Melanosis coli is a brown to black discoloration of the colon mucosa usually associated with long-term ingestion of laxatives. However, melanosis coli can be found in patients with no history of laxative use. Regular use of herbal remedies could be the major source of anthranoid laxatives in such patients. We designed a prospective case series study to identify the clinical characteristics and etiology of melanosis coli in affected patients. This study took place in Ankara, Turkey, between 08/2005 and 11/2006. Patients with endoscopic diagnosis of melanosis coli were interviewed for demographical data and use of herbal remedies. A total of 380 colonoscopies were performed during this period. Melanosis coli was diagnosed endoscopically in 12 patients (3.17%), 11 of whom were found to have characteristic pigment-laden macrophages in histopathological examination. Herbal remedies were the main etiological factor in the development of melanosis coli in 10 out of 11 patients. Diffuse involvement was found in 2 patients who had a history of long-term use. In 8 patients, melanosis coli was located in the left side of the colon. Although melanosis coli is a harmless discoloration of colonic mucosa resulting from complementary or alternative medicine, we believe that this association with herbals was overlooked or not inquired in patients. Therefore, it should be emphasized that “natural” or “alternative” is not equal to “safe”.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
5
Numer
3
Strony
347-353
Opis fizyczny
Daty
wydano
2010-06-01
online
2010-04-09
Twórcy
autor
  • Department of Gastroenterology, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey , tkav@hacettepe.edu.tr
  • Department of Gastroenterology, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey
Bibliografia
  • [1] Muller-Lissner SA Adverse Effects Of Laxatives: Fact And Fiction Pharmacology 1993 Oct;47 Suppl 1:138–45
  • [2] Nusko G, Schneider B, Schneider I, Wittekind CH, Hahn E G Anthranoid Laxative Use Is Not A Risk Factor For Colorectal Neoplasia: Results Of A Prospective Case Control Study Gut 2000;46:651–655 [Crossref]
  • [3] Wald A Is Chronic Use Of Stimulant Laxatives Harmful To The Colon? J Clin Gastroenterol 2003;36(5):386–389 http://dx.doi.org/10.1097/00004836-200305000-00004[Crossref]
  • [4] Tillisch K Complementary And Alternative Medicine For Functional Gastrointestinal Disorders Gut 2006;55:593–596 http://dx.doi.org/10.1136/gut.2005.078089[Crossref]
  • [5] Comar KM., Kirby DF Herbal Remedies In Gastroenterology J Clin Gastroenterol 2005;39:457–468 http://dx.doi.org/10.1097/01.mcg.0000165650.09500.3a[Crossref]
  • [6] Ernst E Complementary Medicine In Gastroenterology: More Than A Fad? J Clin Gastroenterol, Vol 36, No. 5,P:453
  • [7] Kong SC, Hurlstone DP, Pocock CY, Walkington LA, Farguharson NR, Bramble MG, McAlindon ME, Sanders DS. The Incidence Of Self-Prescribed Oral Complementary And Alternative Medicine Use By Patients With Gastrointestinal Diseases J Clin Gastroenterol 2005;39:138–141 http://dx.doi.org/10.1097/01.mcg.0000155570.19340.61[Crossref]
  • [8] Saracoglu A, Ergun B Composition Of Some Herbal Slimming Tea Preparations Marketed In Turkey And Their Possible Adverse Effects Turkiye Klinikleri J Med Sci 2006, 26:355–363
  • [9] Park WK, Cho KA, Hwang DY Clinical Review Of Melanosis Coli. J Korean Soc Coloproctol. 1999 Aug; 15(3):187–193. Korean
  • [10] Ghadially FN, Walley VM Melanoses of the Gastrointestinal Tract Histopathology 1994, 25. 197–207 http://dx.doi.org/10.1111/j.1365-2559.1994.tb01319.x[Crossref]
  • [11] De Witte P, Metabolism And Pharmacokinetics Of Antrhanoids, Pharmacology 1993; 47(Supplement 1): 86–97 http://dx.doi.org/10.1159/000139847[Crossref]
  • [12] Van Gorkom BA, De Vries EG, Karrenbeld A, Kleibeuker JH. Review Article: Anthranoid Laxatives And Their Potential Carcinogenic Effects. Aliment Pharmacol Ther 1999;13(4):443–52 http://dx.doi.org/10.1046/j.1365-2036.1999.00468.x[Crossref]
  • [13] Wang X, Zhong YX, Lan M, Zhang ZY, Shi YQ, Lu J, Ding J, Wu KC, Jin JP, Pan BR, Fan DM. Screening And Identification Of Proteins Mediating Senna Induced Gastrointestinal Motility Enhancement In Mouse Colon World J Gastroenterol 2002;8(1):162–167
  • [14] Folium Sennae, In WHO Monographs On Selected Medicinal Plants Vol. 1 Geneva 1999, Pp: 241–250
  • [15] Tillisch K Complementary and Alternative Medicine for Gastrointestinal Disorders Clin Med 2007;7(3):224–7 [Crossref][PubMed]
  • [16] Langmead L, Rampton DS Review article: complementary and alternative therapies for inflammatory bowel disease Aliment Pharmacol Ther 2006 1; 23 (3) 341–349 http://dx.doi.org/10.1111/j.1365-2036.2006.02761.x[Crossref]
  • [17] Van Tilburg MA, Palsson OS, Levy RL, Feld AD, Turner MJ, Drossman DA, Whitehead WE. Complementary And Alternative Medicine Use And Cost In Functional Bowel Disorders: A Six Month Prospective Study In A Large HMO BMC Complement Altern Med 2008 Jul 24; 8:46 http://dx.doi.org/10.1186/1472-6882-8-46[Crossref]
  • [18] Pardi DS, Tremaine WJ, Rothenberg HJ, Batts KP. Melanosis Coli In Inflammatory Bowel Disease. J Clin Gastroenterol 1998;26:167–170 http://dx.doi.org/10.1097/00004836-199804000-00003[Crossref]
  • [19] Von Gorkom BA, Karrenbeld A, Van Der Sluis T, Zwart N, de Vries EG, Kleibeuker JH. Apoptosis Induction By Sennoside Laxatives In Man; Escape From A Protective Mechanism During Chronic Sennoside Use? J Pathol 2001;194:493–499 http://dx.doi.org/10.1002/path.914[Crossref]
  • [20] Nusko G, Schneider B, Muller G, Kusche J, Hahn EG. Retrospective Study On Laxative Use And Melanosis Coli As Risk Factors For Colorectal Neoplasma. Pharmacology 1993;47Supl 1:234–241 http://dx.doi.org/10.1159/000139863[Crossref]
  • [21] Nusko G, Schneider B, Ernst H, Wittekind C, Hahn EG. Melanosis Coli - A Harmless Pigmentation Or A Precancerous Condition? Z Gastroenterol 1997;35:313–318
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0121-7
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.