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Czasopismo
2010 | 5 | 6 | 745-751
Tytuł artykułu

The effects of intravitreally injected bevacizumab on the retina and retina pigment epithelium: experimental in-vivo electron microscopic study in intact versus vitrectomized eyes

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
To analyze the retinal toxicity of bevacizumab at various doses both in vitrectomized and non-vitrectomized rabbit models. Twenty- eight rabbits were included in the study. Twenty- four rabbits were assigned to six groups, with 4 of the rabbits in the control group. The animals in Groups 1, 2 and 3 received bevacizumab at a dose of 0.3 mg, 0.5 mg and 1.5 mg /eye, respectively. The rabbits in Groups 4, 5 and 6 received intravitreal bevacizumab of 0.3 mg, 0.5 mg and 1.5mg/eye, respectively, after gas compression vitrectomy. Two weeks after the procedure, the rabbits were euthanized. Retina tissue samples were then obtained and examined with both light and electron microscopes. In Groups 1, 2 and 3 after bevacizumab injection, toxic degeneration in the photoreceptor and retinal pigment epithelium cells was observed via electron microscopic examination. The findings in Groups 4 and 5 were normal as compared to the control group. In Group 6, toxicity in the bipolar neurons and photoreceptor cells was noticed. Increased toxicity and retinal penetration were noticed in all administered doses of bevacizumab in the presence of vitreous. In addition, ocular toxicity occurred through the injection of the highest dose of bevacizumab after vitrectomy. It is possible that the bevacizumab dose and the, vitreous are as important as the drug half-life in the vitreous.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
5
Numer
6
Strony
745-751
Opis fizyczny
Daty
wydano
2010-12-01
online
2010-10-07
Twórcy
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey, nkocak@yahoo.com
  • School of Medicine, Histology and Embryology Department, Dokuz Eylul University, 35340, Izmir, Turkey
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey
autor
  • School of Medicine, Histology and Embryology Department, Dokuz Eylul University, 35340, Izmir, Turkey
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey
autor
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey
autor
  • School of Medicine, Ophthalmology Department, Dokuz Eylul University, 35340, Izmir, Turkey
Bibliografia
  • [1] Bakri SJ, Cameron JD. Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model. Am J Ophthalmol 2006;142:162–164 http://dx.doi.org/10.1016/j.ajo.2006.03.058[Crossref]
  • [2] Shahar J, Avery RL, Heilweil G, Barak A, Zemel E, Lewis GP, Johnson PT, Fisher SK, Perlman I, Loewenstein A. Electrophysiologic and retinal penetration studies following intravitreal injection of Bevacizumab (avastin). Retina 2006;26:262–269 http://dx.doi.org/10.1097/00006982-200603000-00002[Crossref]
  • [3] Iriyama A, Chen YN, Tamaki Y, Yanagi Y. Effect of anti-VEGF antibody on retinal ganglion cells in rats. Br J Ophthalmol 2007;91:1230–1233 http://dx.doi.org/10.1136/bjo.2007.117309[Crossref]
  • [4] Spitzer MS, Yoeruek E, Sierra A, Wallenfels-Thilo B, Schraermeyer U, Spitzer B, Bartz-Schmidt KU, Szurman P. Comparative antiproliferative and cytotoxic profile of bevacizumab (Avastin), pegaptanib (Macugen) and ranibizumab (Lucentis) on different ocular cells. Graefe’s Arch Clin Exp Ophthalmol 2007;245:1837–1842 http://dx.doi.org/10.1007/s00417-007-0568-7[WoS][Crossref]
  • [5] Feiner L, Barr EE, Shui YB, Holekamp NM, Brantley MA. Safety of intravitreal injection of bevacizumab in rabbit eyes. Retina 2006;26:882–888 http://dx.doi.org/10.1097/01.iae.0000230717.85319.f5[Crossref]
  • [6] Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–2342 http://dx.doi.org/10.1056/NEJMoa032691[Crossref]
  • [7] Avery RL, Pieramici DJ, Rabena MD, Castellarin AA, Nasir MA, Giust MJ. Intravitreal bevacizumab (avastin) for neovascular age-related macular degeneration. Ophthalmology 2006; 113:363–372 http://dx.doi.org/10.1016/j.ophtha.2005.11.019[Crossref]
  • [8] Yoganathan P, Deramo VA, Lai JC, Tibrewala RK, Fastenberg DM. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina 2006;26:994–998 http://dx.doi.org/10.1097/01.iae.0000244380.34082.67[Crossref]
  • [9] Rich RM, Rosenfeld PJ, Puliafito CA, Dubovy SR, Davis JL, Flynn HW Jr, Gonzalez S, Feuer WJ, Lin RC, Lalwani GA, Nguyen JK, Kumar G. Shortterm safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Retina 2006;26:495–511 http://dx.doi.org/10.1097/01.iae.0000225766.75009.3a[Crossref]
  • [10] Rosenfeld PJ, Fung AE, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. Ophthalmic Surg Lasers Imaging 2005;36:336–339
  • [11] Inan UU, Avci B, Kusbeci T, Kaderli B, Avci R, Temel SG. Preclinical safety evaluation of intravitreal injection of full-length humanized vascular endothelial growth factor antibody in rabbit eyes. Invest Ophthalmol Vis Sci. 2007;48:1773–1781 http://dx.doi.org/10.1167/iovs.06-0828[Crossref]
  • [12] Spaide RF, Fisher YL. Intravitreal bevacizumab (avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage. Retina 2006;26:275–278 http://dx.doi.org/10.1097/00006982-200603000-00004[Crossref]
  • [13] Mason JO III, Albert MA Jr, Vail R. Intravitreal bevacizumab (avastin) for refractory pseudophakic cystoid macular edema. Retina 2006;26:356–357 http://dx.doi.org/10.1097/00006982-200603000-00018[Crossref]
  • [14] Luthra S, Narayanan R, Marques LEA, Chwa M, Kim DW, Dong J, Seigel GM, Neekhra A, Gramajo AL, Brown DJ, Kenney MC, Kuppermann BD. Evaluation of in vitro effects of bevacizumab (avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cells. Retina 2006;26:512–518 http://dx.doi.org/10.1097/01.iae.0000222547.35820.52[Crossref]
  • [15] Manzano RP, Peyman GA, Khan P, Kivilcim M. Testing intravitreal toxicity of bevacizumab (avastin). Retina 2006;26:257–261 http://dx.doi.org/10.1097/00006982-200603000-00001[Crossref]
  • [16] Avery RL. Regression of retinal and iris neovascularization after intravitreal bevacizumab (Avastin) treatment. Retina 2006; 26:352–354 http://dx.doi.org/10.1097/00006982-200603000-00016[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0120-8
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