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2010 | 5 | 1 | 91-96
Tytuł artykułu

Mental retardation and consanguinity in a selected region of the Israeli Arab community

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The prevalence of genetic diseases and congenital malformation in the Israeli Arab community is relatively high, but its distribution is not uniform. The aim of this study was to estimate the frequency of mental retardation disorders in children living in 5 Israeli Arab villages and determine its association with consanguinity. Mental retardation was found to affect 300 children in the screened population, yielding an overall prevalence of 14.5 per 1000. Most of those affected (68%) were the offspring of consanguineous marriages. One village with a high prevalence (4.3%) of neurological hereditary diseases was studied in detail. The prevalence of neurological hereditary diseases and mental retardation associated with consanguinity in these children highlights the need to implement appropriate preventive program.
Wydawca
Czasopismo
Rocznik
Tom
5
Numer
1
Strony
91-96
Opis fizyczny
Daty
wydano
2010-02-01
online
2010-01-29
Twórcy
  • Department of Biochemistry, Faculty of Life Sciences, Tel-Aviv University, 69978, Tel-Aviv, Israel
  • Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel
  • Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel
  • Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel
Bibliografia
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  • [5] Zlotogora J., Haklai Z., Rotem N., Georgi M., Berlovitz I., Leventhal A., Amitai, Y., Relative prevalence of malformations at birth among different religious communities in Israel, Am. J. Med. Genet., A, 2003, 122, 59–62 http://dx.doi.org/10.1002/ajmg.a.20229[Crossref]
  • [6] Sharkia R., Zaid M., Athamna A., Cohen D., Azem A., Zalan A., The changing pattern of consanguinity in a selected region of the Israeli Arab community, Am. J. Hum. Biol., 2008, 20, 72–77 http://dx.doi.org/10.1002/ajhb.20678[Crossref][WoS]
  • [7] Zlotogora J., Molecular basis of autosomal recessive diseases among the Palestinian Arabs, Am. J. Med. Genet., 2002, 109, 176–182 http://dx.doi.org/10.1002/ajmg.10328[Crossref]
  • [8] Mental Retardation: Classification and Systems of Supports, American Association on Mental retardation, 2002, 10th edn, Washington.
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  • [13] Santos C., Rodriguez-Revenga L., Madrigal I., Badenas, C., Pineda M., Mila M., A novel mutation in JARID1C gene associated with mental retardation, Eur. J. Hum. Genet., 2006, 14, 583–586 http://dx.doi.org/10.1038/sj.ejhg.5201608[Crossref]
  • [14] Basel-Vanagaite L., Taub E., Halpern G.J., Drasinover V., Magal N., Davidov B., et al., Genetic screening for autosomal recessive nonsyndromic mental retardation in an isolated population in Israel, Eur. J. Hum. Genet., 2007, 15, 250–253 http://dx.doi.org/10.1038/sj.ejhg.5201750[Crossref][WoS]
  • [15] Uyguner O., Kayserili H., Li Y., Karaman B., Nurnberg G., Hennies H. C., et al., A new locus for autosomal recessive non-syndromic mental retardation maps to 1p21.1–p13.3, Clin. Genet., 2007, 71, 212–219 http://dx.doi.org/10.1111/j.1399-0004.2007.00762.x[Crossref]
  • [16] Stromme P., Valvatne K., Mental retardation in Norway: prevalence and sub-classification in a cohort of 30037 children born between 1980 and 1985, Acta. Paediatr. 1998, 87, 291–296 http://dx.doi.org/10.1080/08035259850157345
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  • [19] Jaber L., Halpern G.J., Shohat T., Trends in the frequencies of consanguineous marriages in the Israeli Arab community, Clin. Genet., 2000, 58, 106–110 http://dx.doi.org/10.1034/j.1399-0004.2000.580203.x[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0112-8
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