PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2010 | 5 | 5 | 541-543
Tytuł artykułu

Intracranial plasmacytoma as an initial presentation of multiple myeloma

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Intra-cranial involvement is an uncommon complication of multiple myeloma. We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple myeloma subsequent to initial intrcranial involvement is confined to exceptional cases. Despite aggressive systemic treatments, including autologous stem cell transplantation and local treatments such as cerebral radiotherapy, the prognosis for patients with CNS myeloma is extremely poor. Our unique case implies that physicians should be alert in case of vertigo or headache in cases with acute renal failure.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
5
Numer
5
Strony
541-543
Opis fizyczny
Daty
wydano
2010-10-01
online
2010-08-20
Twórcy
autor
  • Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey , aleverikci@yahoo.com
autor
  • Departments of Hematology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Oncology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Pathology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
  • Departments of Radiology, GATA Haydarpasa Training Hospital, 34668, Istanbul, Turkey
Bibliografia
  • [1] Fassas ABT, Muwalla F, Berryman T, Berryman T, Benramdane R, Joseph, L et al. Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and extra-medullary manifestations. Br J Haematol 2002;117;103–108 http://dx.doi.org/10.1046/j.1365-2141.2002.03401.x[Crossref]
  • [2] Petersen S, Wagner A, Gimsing P. Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature. Am J Hematol 1999;62; 228–233 http://dx.doi.org/10.1002/(SICI)1096-8652(199912)62:4<228::AID-AJH5>3.0.CO;2-3[Crossref]
  • [3] Nieuwenhuizen L, Biesma DH. Central nervous system myelomatosis: review of the literature. Eur J Haematol. 2008;80; 1–9 [PubMed]
  • [4] Kaplan JG, DeSouza TG, Farkash A, Shafran B, Pack D, Rehman F, Fuks J, Portenoy R. Leptomeningeal metastases: comparison of clinical features and laboratory data of solid tumors, lymphomas, and leukemias. J Neurooncol 1990;9; 225–229 http://dx.doi.org/10.1007/BF02341153[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0104-8
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.