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2010 | 5 | 4 | 478-485
Tytuł artykułu

Accuracy of quantitative ultrasound parameters in the diagnosis of osteoporosis

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Języki publikacji
EN
Abstrakty
EN
Quantitative ultrasound (QUS) is of increasing interest for evaluation of osteoporosis because, compared with dual-energy X-ray absorptiometry (DXA), it is portable, less expensive, and radiation-free. The aim of our study was to determine the sensitivity, specificity, and cut-off values of quantitative ultrasound parameters in identifying patients with osteoporosis compared to the World Health Organization (WHO) standard definition. We performed a cross-sectional investigational study of 73 subjects, and determined total hip and lumbar spine T-scores by dual-energy X-ray absorptiometry (DXA) (Prodigy Advance Lunar-GE). The QUS parameters (broadband ultrasound attenuation [BUA], speed of sound, bone mineral density, the stiffness index, and QUS T-score) were determined with Sahara Hologic equipment. The AUC was 0.81 (95% CI 0.67–0.95, p<0.05) for speed of sound (SOS) and 0.76 (95% CI 0.62–0.90, p<0.05) for BUA for the patients with DXA T-scores ≥ −1 DS; the cut-off values were 1542.2 meters per second for SOS and 63.3 dB/MHz for BUA. In patients with DXA T-scores ≤ − 2.5 DS, AUC was 0.80 (95% CI 0.70–0.90, p<0.05) for SOS, and 0.76 (95% CI 0.65–0.87, p<0.05) for BUA. The cut-off values were 1504.95 meters per second for SOS and 49.5 dB/MHz for BUA. Pearson correlation coefficients were positive and statistically significant (> 50%) for all QUS parameters in both groups, (2-tailed, p<0.05). QUS parameters correctly identified normal patients (false negative 34.21% and false positive 2.53%) and those with osteoporosis (false negative 8.55% and false positive 7.82%). The patients with QUS parameters between the cut-off values corresponding to DXA T-scores of −1 SD and − 2.5 SD should be further evaluated by DXA.
Wydawca

Czasopismo
Rocznik
Tom
5
Numer
4
Strony
478-485
Opis fizyczny
Daty
wydano
2010-08-01
online
2010-05-30
Twórcy
autor
  • Department of Internal Medicine II and Rheumatology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania, ralu_pais@yahoo.com
  • Department of Statistics, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania
  • Department of Internal Medicine II and Rheumatology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania
  • Department of Radiology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania
  • Department of Internal Medicine II and Rheumatology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania
  • Department of Internal Medicine II and Rheumatology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca, 400012, Cluj-Napoca, Romania
Bibliografia
  • [1] Kanis J.A., McCloskey E.V., Johansson H., Oden A., Melton J.L., Khaltaev N., A reference standard for the description of osteoporosis, Bone, 2008, 42, 467–475 http://dx.doi.org/10.1016/j.bone.2007.11.001[Crossref][WoS]
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  • [4] Sahara Clinical User’s Guide, 1998, Hologic Inc, USA
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  • [16] Falgarone G., Porcher R., Duche’ A., Kolta S., Dougados M., Roux C., Discrimination of osteoporotic patients with quantitative ultrasound using imaging or non-imaging device, Joint Bone Spine, 2004, 71, 419–423 http://dx.doi.org/10.1016/j.jbspin.2003.09.011[Crossref]
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  • [18] Damilakis J., Perisinakis K., Gourtsoyiannis N., Ultrasonometry of the Calcaneus: Optimum T-Score Thresholds for the Identification of Osteoporotic Subjects, Calcif Tissue Int., 2001, 68, 219–224 http://dx.doi.org/10.1007/s002230020014[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0076-8
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