Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2010 | 5 | 2 | 227-234
Tytuł artykułu

An increase of elastic tissue fibers in blood vessel walls of placental stem villi and differences in the thickness of blood vessel walls in third trimester pre-eclampsia pregnancies

Treść / Zawartość
Warianty tytułu
Języki publikacji
This study has goals of examining whether pre-eclampsia may lead to an increase of elastic tissue fibers in blood vessel walls of placental stem villi or whether there are differences in the thickness of blood vessel walls within these villi when compared to normotensive pregnant women. Non-infarcted placental tissue samples from 28 participants with uncomplicated pregnancies and 26 patients with pre-eclampsia were obtained. After routine histological procedures, the sections were processed either for conventional Verhoeff staining for the demonstration of elastic fiber system. Paraffine sections from placenta biopsies prepared for light microscopic examination were gathered. In uncomplicated pregnancies, terminal villi blood vessels were observed with no stained elastic tissue fibers in most areas. In the pre-eclampsia pregnancy of human placenta, the elastic fibers significiantly increased in terminal villi blood vessel walls which were dark in color, using Verhoeff’s tissue stain, when comparing with the uncomplicated pregnancy group. Our results indicate that an increase of elastic tissue fibers in blood vessels of placental stem villus and terminal villi, and also an increase of wall thickness during pre-eclampsia.
Słowa kluczowe

Opis fizyczny
  • Medical School, Department of Histology and Embryology, Dicle University, 21280, Diyarbakir, Turkey
  • Medical School, Department of Anatomy, Dicle University, 21280, Diyarbakir, Turkey,
  • Medical School, Department of Histology and Embryology, Dicle University, 21280, Diyarbakir, Turkey
  • Medical School, Department of Histology and Embryology, Dicle University, 21280, Diyarbakir, Turkey
  • Medical School, Department of Obstetric and Gynecology, Dicle University, 21280, Diyarbakir, Turkey
  • Medical School, Department of Pathology, Dicle University, 21280, Diyarbakir, Turkey
  • [1] Redman C.W., Sargent I.L., The pathogenesis of pre-eclampsia. Gynecol. Obstet. Fertil., 2001, 29, 518–522[Crossref]
  • [2] Rajagopal M., Moodley J., Chetty R., Nitric oxide: does it have an etiological role in pre-eclampsia?. Acta. Obstet. Gynecol. Scand., 2003, 82, 216–219
  • [3] Wilhelm D., Mansmann U., Neudeck H., Matejevic D., Vetter K., Graf R., Increase of segments of elastictype blood vessel walls in fetal placental stem villi during pre-eclampsia at term. Anat. Embryol., 1999, 200, 597–605[Crossref]
  • [4] Moore K.L., Persaud TVN. The developing human. Clinically oriented embryology. 6th ed, W.B. Saunders Company Philadelphia,1998
  • [5] Pawlicka E., Bankowski E., Jaworski S., Elastin of the umbilical cord arteries and its alterations in EPH gestosis (preeclampsia). Biol. Neonate., 1999, 975, 91–96[Crossref]
  • [6] Romanowicz L., Sobolewski K., Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia. J. Perinat. Med., 2000, 28, 140–146[Crossref]
  • [7] Junek T., Baum O., Läuter H., Vetter K., Matejevic D., Graf R., Pre-eclampsia associated alterations of the elastic fibre system in umbilical cord vessels. Anat. Embryol., 2000, 201, 291–303[Crossref]
  • [8] Griffin D., Bilardo K., Masini L., Diaz-Recasens J., Pearce J.M., Wilson K., Campbell S., Doppler blood flow waveforms in the descending thoracic aorta of the human fetus. Br. J. Obstet. Gynecol., 1984, 91, 997–1006
  • [9] Al-Ghazali W., Chita S.K., Chapman M.G., Allan L.D., Evidence of redistribution of cardiac output in asymmetrical growth retardation. Br. J. Obstet. Gynecol., 1989, 96, 697–704
  • [10] Wilhelm D., Mansmann U., Neudeck H., Matejevic D., Vetter K., Graf R., Decrease of elastic tissue fibers in stem villus blood vessels of the human placenta during IUGR and IUGR with concomitant pre-eclampsia. Anat. Embryol., 2002, 205, 393–400[Crossref]
  • [11] Kielty C.M., Sherratt M., Shuttleworth J.C.A., Elastic fibers. Journal of Cell Science, 2002, 115, 2817–2828
  • [12] Colombatti A., Doliana R., Bot S., Canton A., Mongiat M., Mungiguerra G., Paron-Cilli S., Spessotto P., The EMILIN protein family. Matrix. Biol., 2000, 19, 289–301[Crossref]
  • [13] Baccarini-Contri M., Taparelli F., Miselli M., Bachelli B., Biagini G., Histomorphometric, biochemical and ultrastructural change in the aorta of salt-loaded stroke-prone spontaneously hypertensive rats fed a Japanese-style diet. Nutr. Metab. Cardiovasc. Dis., 2003, 13, 37–45[Crossref]
  • [14] Keeley F.W., Bartoszewicz L.A., Elastin in systemic and pulmonary hypertension. Ciba. Found. Symp., 1995, 192, 259–273
  • [15] Urban Z., Riazi S., Seidi T.L., Katahira J., Smoot L.B., Chitayat D., Boyd C.D., Hinek A., Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am. J. Hum. Genet., 2002, 71, 30–44[Crossref]
  • [16] Hamlin N., Beck K., Bacchelli B., Cianciulli P., Pasquali-Ronchetti I., Le Saux O., Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients. Br. J. Haematol., 2003, 12, 852–854[Crossref]
  • [17] Arribas S.M., Hinek A., González M.C., Elastic fibers and vascular structure in hypertension. Pharmacology & Therapeutics. 2006, 111, 771–791[Crossref]
  • [18] Edna B., Arrington B., Sobin H., Laboratory methods in Histotechnology. American Registry of Pathology, Washington. D.C., 1992, 134–135
  • [19] Barros J.S., Gonçalves C.A., Bairos V.A., Elastic fibers in the human placenta. Arch. Gynecol. Obstet., 2003, 267, 208–212
  • [20] Barker D.J., Bull A.R., Osmond C., Simmonds S.J., Fetal and placental size and risk of hypertension in adult life. Br. Med. J., 1990, 301, 259–262[Crossref]
  • [21] Barker D.J.P., Fetal origins of coronary heart disease. Br. Med. J., 1995, 311, 171–174
  • [22] Martyn C.N., Barker D.J.P., Jespersen S., Greenwald S., Osmond C., Berry C., Growth in utero, adult blood pressure and arterial compliance. Br. Heart. J., 1995, 73, 116–121[Crossref]
  • [23] Bendeck M.P., Langille B.L., Rapid accumulation of elastin and collagen in the aorta of sheep in the immediate perinatal period. Circ. Res., 1992, 69, 1165–1169
  • [24] Berry C.L., Looker T., Germaine J., Nucleic acid and scleroportein content of the developing human aorta. J. Pathol., 1972, 108, 265–274[Crossref]
  • [25] Davis E.C., Elastic lamina growth in the developing mouse aorta. J. Hystochem. Cytochem., 1995, 43, 1115–1123 [Crossref]
  • [26] Rosenbloom J., Abrams W.R., Mecham R., Extracellular matrix 4: the elastic fiber. FASEB J., 1993, 7, 1208–1218
  • [27] Martyn C.N., Greenwald S.E., Impaired syntesis of elastin in walls of aorta and large conduit arteries during early development as an initiating event in pathogenesis of systemic hypertension. Lancet, 1997, 350, 953–955[Crossref]
  • [28] Martyn C.N., Greenwald S.E., Fetal origins of adult isease. A hypothesis about a mechanism for the programming of blood pressure and vascular disease in early life. Clin. Exp. Pharmacol. Physiol., 2001, 28, 498–503[Crossref]
  • [29] Xu C., Zarins C.K., Pannaraj P.S., Bassiouny H.S., Glagov S., Hypercholesterolemia Superimposed by Experimental Hypertension Induces Differential Distribution of Collagen and Elastin. Arteriosclerosis, Thrombosis, and Vascular Biology, 2000, 20, 2566–2572 [Crossref]
  • [30] Ito H., Kwan C.Y., Daniel E.E., Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. Exper. Mol. Pathol., 1987, 47, 26–36[Crossref]
  • [31] Hadjiisky P., Peyri N., Grosgogeat Y., Tunica media changes in the spontaneously hypertensive rat ? SHR. Atherosclerosis, 1987, 65, 125–137[Crossref]
  • [32] Fridez P., Zulliger M., Bobard F., Montorzi G., Miyazaki H., Hayashi K., Stergiopulos N., Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension. J. Biomechanics., 2003, 36, 671–680[Crossref]
  • [33] Keeley F.W., Johnson D.J., The effect of developing hypertension on the synthesis and accumulation of elastin in the aorta of the rat. Biochem. Cell. Biol., 1986, 64, 38–43[Crossref]
  • [34] Wolinsky H., Responses of the rat aortic media to hypertension. Circ. Res., 1970, 26, 507–522 [Crossref]
  • [35] Hahn S., Fetal Cells and Cell Free Fetal Nucleic Acids in Maternal Blood. New Tools to Study Abnormal Placentation?. Placenta, 2005, 26, 515–526[Crossref]
  • [36] Graff R., Gossrau R., Neudeck H., Matejevic D., Vetter K., The elastic fiber system in the human placenta with special reference to elastic-type blood vessels. In: Morrish D., Miller R.K., (Eds.), Trophoblast research 11. Genetic regulation of placental development and immunology. University of Rochester Press, Rochester,1998
  • [37] Saleh R.A., Dkhil M.A.M., Structural Changes of Placenta in Preeclamptic Patients: Light and Electron Microscopic Study. Turk. J. Med. Sci., 2008, 38, 219–225
  • [38] Stenmark K.R., Fasules J., Hyde D.M., Voelkel N.F., Henson J., Tucker A., Wilson H., Reeves J.T., Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. J. Appl. Physiol., 1987, 62, 821–830
  • [39] Las Heras J., Haust M.D., Haeding P.G.R., Morphology of fetal placental stem arteries in hypertensive disorders (toxemia) of pregnancy. Appl. Pathol., 1983, 1, 301–309
  • [40] Las Heras J., Haust M.D., Ultrastructure of third order fetal arteries in normal and “toxemic” placentas. Lab. Invest., 1980, 42, 130–131
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.