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2009 | 4 | 2 | 184-191
Tytuł artykułu

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.
Słowa kluczowe
Wydawca

Czasopismo
Rocznik
Tom
4
Numer
2
Strony
184-191
Opis fizyczny
Daty
wydano
2009-06-01
online
2009-03-27
Twórcy
autor
  • Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
  • Department of Physiology, Faculty of Veterinary Medicine, University of Atatürk, 25700, Erzurum, Turkey, karadenizali@gmail.com
  • Department of Biochemistry, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
  • Department of Histology and Embryology, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
autor
  • Department of Biochemistry, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
  • Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
autor
  • Department of Internal Medicine, Faculty of Medicine, University of Atatürk, 25700, Erzurum, Turkey
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0021-x
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