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2009 | 4 | 1 | 17-25
Tytuł artykułu

Pressor responses to hyperventilation in elderly subjects differentiate essential from secondary hypertension

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We evaluated pressor responses to the hyperventilation test in elderly normotensive (n=43, mean age 82 ± 5 years) and elderly hypertensive subjects (n=45 with essential hypertension, mean age 82 ± 2 years, and n=49 with secondary hypertension, mean age 82 ± 3 years). Hyperventilation did not change blood pressure (BP) in normotensive and secondary hypertensive subjects, whereas it decreased BP in essential hypertensives. Hierarchical cluster analysis based on BP responses to hyperventilation disclosed three groups of subjects in each population: group 1 exhibited a reduction in BP (essential hypertensives: 76%), group 2 no change (normotensives: 70%, secondary hypertensives: 76%), and group 3 an increase (normotensives: 19%, essential hypertensives: 13%, secondary hypertensives: 14%). Ambulatory BP monitoring found significant differences in pressor daytime profiles of hypertensive patients according to pressor responses to hyperventilation showing wide fluctuations in group 1 and 3 patients. Interestingly, the peak ambulatory SBP values correlated to the pre-hyperventilation SBP values in group 1, and to the hyperventilation peak SBP values in group 3. In conclusion: 1) Aging decreases reactivity to respiratory alkalosis in elderly normotensives; 2) hyperventilation induces significant pressor changes frequently in essential hypertension, but rarely in secondary hypertension; 3) the significant pressor responses to hyperventilation reflect the daytime pressor profiles predicting the highest daily fluctuations of BP values.
Wydawca

Czasopismo
Rocznik
Tom
4
Numer
1
Strony
17-25
Opis fizyczny
Daty
wydano
2009-03-01
online
2009-02-11
Twórcy
  • Dipartimento di Medicina Interna, dell’Invecchiamento e delle Malattie Nefrologiche, Università di Bologna, Ospedale S. Orsola, 40138, Bologna, Italy, fiorella.fontana@unibo.it
  • Dipartimento di Medicina Interna, dell’Invecchiamento e delle Malattie Nefrologiche, Università di Bologna, Ospedale S. Orsola, 40138, Bologna, Italy
  • Dipartimento di Medicina Interna, dell’Invecchiamento e delle Malattie Nefrologiche, Università di Bologna, Ospedale S. Orsola, 40138, Bologna, Italy
autor
  • Discovery Medicine, GlaxoSmithKline, Medicine Research Center, 37135, Verona, Italy
Bibliografia
  • [1] Fontana F., Bernardi P., Merlo Pich E., Tartuferi L., Boschi S., Spampinato S., Opioid peptide modulation of circulatory response to hyperventilation in humans, Peptides, 2000, 21, 1223–1230 http://dx.doi.org/10.1016/S0196-9781(00)00263-1[Crossref]
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  • [3] Fontana F., Bernardi P., Lanfranchi G., Pisati M.S., Merlo Pich E., Blood pressure response to hyperventilation test reflects daytime pressor profile. Hypertension, 2003, 41, 244–248 http://dx.doi.org/10.1161/01.HYP.0000052315.51182.3D[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-009-0002-0
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