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Czasopismo
2009 | 4 | 3 | 340-347
Tytuł artykułu

Effect of Plasmodium and Salmonella co-infection in a murine model

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The present study was designed to evaluate the effect of Plasmodium and Salmonella co-infection in LACA mice. The parasitaemic level, bacterial load, histological alterations and levels of oxidants/antioxidant activity were measured. Co-infected mice had a high parasitaemic level, increased bacterial load, and died earlier than Plasmodium-infected mice. Histologically, co-infected mice had more architectural damage in the liver, spleen, kidney, and brain than the control groups. The level of lipid peroxidation was significantly increased and the activities of antioxidative enzymes (superoxide dismutase and catalase) were decreased in all organs of co-infected mice compared to the control groups, indicating depression of the antioxidant defense system. The present study demonstrates more severe histological and biochemical alterations in co-infected mice, highlighting the importance of early diagnosis for selection of appropriate treatments and reducing the likelihood of further complications.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
4
Numer
3
Strony
340-347
Opis fizyczny
Daty
wydano
2009-09-01
online
2009-07-03
Twórcy
autor
autor
  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
autor
  • Department of Biophysics, Panjab University, Chandigarh, 160 014, India
  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-008-0092-0
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