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2009 | 4 | 3 | 340-347
Tytuł artykułu

Effect of Plasmodium and Salmonella co-infection in a murine model

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The present study was designed to evaluate the effect of Plasmodium and Salmonella co-infection in LACA mice. The parasitaemic level, bacterial load, histological alterations and levels of oxidants/antioxidant activity were measured. Co-infected mice had a high parasitaemic level, increased bacterial load, and died earlier than Plasmodium-infected mice. Histologically, co-infected mice had more architectural damage in the liver, spleen, kidney, and brain than the control groups. The level of lipid peroxidation was significantly increased and the activities of antioxidative enzymes (superoxide dismutase and catalase) were decreased in all organs of co-infected mice compared to the control groups, indicating depression of the antioxidant defense system. The present study demonstrates more severe histological and biochemical alterations in co-infected mice, highlighting the importance of early diagnosis for selection of appropriate treatments and reducing the likelihood of further complications.
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  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
  • Department of Biophysics, Panjab University, Chandigarh, 160 014, India
  • Department of Microbiology, Panjab University, Chandigarh, 160 014, India
  • [1] Gilson R.J., Hawkins A.E., Beecham M.R., Ross E., Waite J., Briggs M., McNally T., Kelly G.E., Tedder R.S., Weller I.V., Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection, AIDS, 1997, 11, 597–606[Crossref]
  • [2] Xiao L., Owen S.M., Rudolph D.L., Lal R.B., Lal A., Plasmodium falciparum antigen-induced human immunodeficiency virus type-1 replication is mediated through induction of tumor necrosis factor alpha, J. Infect. Dis., 1998, 177, 437–445[Crossref]
  • [3] Froebel K., Howard W., Schafer J.R., Howie F., Whitworth J., Kaleebu P., Brown A.L., Riley E., Activation by malaria antigens renders mononuclear cells susceptible to HIV infection and re-activates replication of endogenous HIV in cells from HIV-infected adults, Parasit. Immunol., 2000, 26, 213–217[Crossref]
  • [4] Bhan M.K., Bahl R., Sazawal S., Sinha A., Kumar R., Mahalanabis D., et al., Association between Helicobacter pylori infection and increased risk of typhoid fever. Journal of Infectious Diseases, 2000, 186,12, 1857–1860[Crossref]
  • [5] Keong B.C.M., Sulaiman W., Typhoid and malaria Coinfection - An interesting finding in the investigation of a Tropical fever, Malaysian J. Medical Sciences, 2006, 13,1, 74–75
  • [6] Frimpong E.H., Feglo P., Essel-Ahun M., Addy P.A.K., Determination of diagnostic widal titers in Kumasi Ghana, West Afr. J. Med., 2000, 19, 34–38
  • [7] Petit P.L.C., Wamola I.A., Typhoid fever. A review of its impact and diagnostic problems, East Afr. med. J. 1999, 11, 183–188
  • [8] Bronzan R.N., Taylor T.E., Mwenechanya J., Temb M., Kayira K., Bwanasia L., et al., Bacteremia in Malawian Children with Severe Malaria: Prevalence, Etiology, HIV Co-infection and outcome, Infectious Disease, 2000, 195, 895–904[Crossref]
  • [9] Lowry O.H., Rosenbrough N.J., Farr A.L. Randell R.J., Protein measurement with folin’s phenol reagent, J. Biol Chem., 1951, 193, 265–275
  • [10] Wills E.D., Mechanism of lipid peroxidation formation in animal tissues, Biochem. J., 1966, 99, 667–676
  • [11] Ellman G.L., Tissue sulfhydryl groups, Arch. Biochem., 1959, 82, 70–77[Crossref]
  • [12] Kono Y., Generation of superoxide radical during autooxidation of hydroxylamine and an assay of superoxide dismutase, Arch. Biochem. Biophys., 1978, 186, 189–195[Crossref]
  • [13] Claiborne A., Handbook of Methods for Oxygen Radical Research, CRC Press, 1985
  • [14] Zuckerman A., Blood loss and replacement in Plasmodium infection I., Plasmodium berghei in untreated rats of varying age and in adult rats with erythropoetic mechanisms manipulated before inoculation, J. Infect. Diseases, 1957, 100, 172–177 [Crossref]
  • [15] Richter-Dahlfors A., Buchan A.M.J., Finlay B.B., Murine Salmonellosis Studied by Confocal Microscopy: Salmonella resides intracellularly inside macrophages and exerts a cytotoxic effect on phagocytes in vivo, J. Exp. Med., 1997, 186, 569–580[Crossref]
  • [16] Ninalue N.A., Shnyra A., Hultenby K., Linderberg A.A., Salmonella choleraesuis and Salmonella typhimurium associated with liver cells after intravenous inoculation of rats are localized mainly in kupffer cells and multiply intracellularly, Infect. Immun., 1992, 60, 2758–2768
  • [17] Clark A., Chaudhri G., Cowden W.B., Some roles of free radicals in malaria, Free Rad Boil Med, 1989, 6, 315–321[Crossref]
  • [18] Siddiqui N.J., Puri S.K., Dutta G.P., Maheshwari R.K., Pandey V.C., Studies on hepatic oxidative stress and antioxidant defence system during chloroquine/poly ICLC treatment of Plasmodium yoelii nigeriensis infected mice, Molecular and Cellular Biochemistry, 1999, 194, 179–183[Crossref]
  • [19] Rishi P., Kaur H., Tirkey N., Chopra K., Bharrhan S., Chanana V., Koul A., Are the increases in local tumor necrosis factor and lipid peroxidation observed in pre-starved mice infected with Salmonella typhimurium, markers of increased liver damage, Microbes. Infect., 2006 (In press) [Crossref]
  • [20] Srivastava P., Puri S.K., Dutta G.P., Pandey V.C., Hepatic superoxide scavenging system during Plasmodium berghei infection and chloroquine treatment, Med. Sci. Res., 1991, 19, 307–308
  • [21] Kremsner P.G., Greve B., Lell B., Luckner D., Schmid D., Malarial anemia in African children associated with high oxygen radical production, Lancet, 2000, 355, 40–41[Crossref]
  • [22] Windrow V.R., Winyard P.G., Morris C.J. Blake D.R. Free radicals in inflammation: second messengers and mediators of tissue destruction, Br. Med. Bull., 1993, 49, 506–522
  • [23] Jaesctike H., Enhanced sinusoidal glutathione efflux during endotoxin induced stress in vivo, Am. J. Physiol., 1992, 263, G60–G68
  • [24] Mehta A., Singh S., Ganguly N.K., Role of reactive oxygen species in Salmonella typhimurium-induced enterocyte damage, Scand. J. Gastroenterol., 1998, 33,4, 406–414[Crossref]
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