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2009 | 4 | 2 | 241-244
Tytuł artykułu

Plasma apelin levels in diabetic patients with and without neuropathy

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of this study was to investigate the plasma apelin levels in diabetic patients with and without neuropathy. All consecutive diabetic patients who presented for routine follow-up at our outpatient clinic were invited to participate in this clinical study. Forty diabetic patients (20 female and 20 male) and twenty-two non-diabetic control subjects (9 female and 13 male) were included in the study. Neurological evaluations in diabetic subjects were done by nerve conduction studies and evaluated with the Neuropathy Symptom Score. Fasting plasma glucose, HbA1c, lipid and apelin levels were measured in each subject. The mean plasma apelin level was significantly higher in the diabetic patients than in the control subjects (p = 0.026). Apelin levels were statistically similar between diabetic patients with and without neuropathy (p = 0.43). Further, plasma apelin levels were found to be higher in diabetic patients with neuropathy when compared with those of healthy control subjects (p = 0.02). In diabetic patients with neuropathy, plasma apelin levels correlated significantly with diabetes duration (r = 0.5, p = 0.02). We propose that apelin levels in diabetic patients are higher in the presence of neuropathy and longer disease duration, although this might not solely suffice as an indicator for the presence of neuropathy in diabetic patients. Drawing attention to the possible association between the apelinergic system and diabetes mellitus, we believe that further studies with larger samples should be carried out also to investigate the presence of retinopathy and nephropathy.
Wydawca

Czasopismo
Rocznik
Tom
4
Numer
2
Strony
241-244
Opis fizyczny
Daty
wydano
2009-06-01
online
2009-03-27
Twórcy
  • Department of Neurology, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey, mgsenol@yahoo.com
  • Department of Internal Medicine, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Biochemistry, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Internal Medicine, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Neurology, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Neurology, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
autor
  • Department of Internal Medicine, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Internal Medicine, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Neurology, Gülhane Military Medical Academy Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
Bibliografia
  • [1] Lee D.K., George S.R., O’Dowd B.F., Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity, Trends Pharmacol. Sci., 2006, 27, 190–194 http://dx.doi.org/10.1016/j.tips.2006.02.006[Crossref]
  • [2] Kleinz M.J., Davenport A.P., Emerging roles of apelin in biology and medicine, Pharmacol. Ther., 2005, 107, 198–211 http://dx.doi.org/10.1016/j.pharmthera.2005.04.001[Crossref]
  • [3] Erdem G., Dogru T., Tasci I., Sonmez A., Tapan S., Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus, Exp. Clin. Endocrinol. Diabetes., 2008, 116, 289–292 http://dx.doi.org/10.1055/s-2007-1004564
  • [4] Matthews D.R., Hosker J.P., Turner R.C., Homeostasis Model Assesment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 1985, 28, 412–419 http://dx.doi.org/10.1007/BF00280883[Crossref]
  • [5] Dyck P.J., Detection, characterization and staging of polyneuropathy: assessed in diabetics, Muscle. Nerve., 1998, 11, 21–32 http://dx.doi.org/10.1002/mus.880110106[Crossref]
  • [6] Bełtowski J., Apelin and visfatin: Unique “beneficial” adipokines upregulated in obesity? Med. Sci. Monit., 2006, 12, 112–119
  • [7] Ladeiras-Lopes R., Ferreira-Martins J., Leite-Moreira A.F., The Apelinergic System: The Role Played in Human Physiology and Pathology and Potential Therapeutic Applications. Arq. Bras. Cardiol., 2008, 90, 343–349 http://dx.doi.org/10.1590/S0066-782X2008000500012[Crossref]
  • [8] Boucher J., Masri B., Daviaud D., Gesta S., Guignö C., Mazzucotelli A., et al., Apelin, a newly identified adipokine up-regulated by insulin and obesity, Endocrinology, 2005, 146, 1764–1771 http://dx.doi.org/10.1210/en.2004-1427[Crossref]
  • [9] Li L., Yang G., Li Q., Tang Y., Yang M., Yang H., Li K., Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects, Exp. Clin. Endocrinol. Diabetes., 2006, 114, 544–548 http://dx.doi.org/10.1055/s-2006-948309
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-008-0075-1
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