PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2010 | 5 | 1 | 115-122
Tytuł artykułu

The effects of parenteral glutamine on intestinal adaptation in a rat model of short bowel syndrome

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Short bowel syndrome (SBS) is characterized by the malabsorption of nutrients and fluids that occurs after major intestinal resection, resulting from an adaptation process that begins immediately to increase the mucosal surface area and absorption. Certain nutrients and trophic factors are widely used to increase intestinal adaptation following massive intestinal resection. The efficacy and benefits of glutamine on the intestinal adaptation process is still controversial. This study was conducted to determine the effects of parenteral glutamine administration on intestinal adaptation in a rat model of SBS. Fourteen male Wistar rats were divided into two groups; all 14 underwent 75% small bowel resection. Within each group, rats were assigned to 14 days of treatment with subcutaneous glutamine (0.3 g/kg/day) or isotonic saline daily. Weight changes and histological intestinal adaptation parameters (mucosal thickness, villus height, and crypt depth) were measured. Non-mucosal intestinal changes were evaluated by intestinal fractioned collagen analysis. All rats initially lost weight and began to gain weight postoperatively; however, they did not reach their preoperative weights during the experiment and there was no significant difference between the groups. Histological adaptation parameters were significantly increased after 75% intestinal resection in both groups compared to paired native samples (P<0.01); although the percent of increase was slightly higher in Gln group, no significant difference was detected between the two groups. Fractioned-collagen amounts were found to be similar between groups. The results indicated that parenteral glutamine administration alone does not improve the intestinal adaptation process after massive intestinal resection in rats.
Wydawca

Czasopismo
Rocznik
Tom
5
Numer
1
Strony
115-122
Opis fizyczny
Daty
wydano
2010-02-01
online
2010-01-29
Twórcy
autor
  • Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey
autor
  • Basic Oncology, Institute of Oncology, Dokuz Eylul University, 35340, Izmir, Turkey
autor
  • Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey, emre.canda@deu.edu.tr
autor
  • Pathology School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey
  • Preventive Oncology, Institute of Oncology4, Dokuz Eylul University, 35340, Izmir, Turkey
  • Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey
Bibliografia
  • [1] Scolapio J.S., Treatment of short-bowel syndrome, Curr. Opin. Clin. Nutr. Metab. Care., 2001, 4, 557–60 http://dx.doi.org/10.1097/00075197-200111000-00017[Crossref]
  • [2] Shanbhogue L.K., Molenaar J.C., Short bowel syndrome: metabolic and surgical management, Br. J. Surg., 1994, 81, 486–99 http://dx.doi.org/10.1002/bjs.1800810404[Crossref]
  • [3] Andorsky D.L., Lund D.P., Lillehei C.W., Jaksic T., Dicanzio J., Richardson D.S., et al., Nutritional and other postoperative management of neonates with short bowel syndrome-correlates with clinical outcomes, J. Pediatr., 2001, 139, 27–33 http://dx.doi.org/10.1067/mpd.2001.114481[Crossref]
  • [4] Li-Ling, Irving M., The effectiveness of growth hormone, glutamine and a low-fat diet containing high-carbohydrate on the enhancement of the function of remnant intestine among patients with short bowel syndrome: a review of published trials, Clin. Nutr., 2001, 20, 199–204 http://dx.doi.org/10.1054/clnu.2001.0423[Crossref]
  • [5] Liu Y.W., Bai M.X., Ma Y.X., Jiang Z.M., Effects of alanyl-glutamine on intestinal adaptation and bacterial translocation in rats after 60% intestinal resection, Clin. Nutr., 1997, 16, 75–8 http://dx.doi.org/10.1016/S0261-5614(97)80026-X[Crossref]
  • [6] Ziegler T.R., Mantell M.P., Chow J.C., Rombeau J.L., Smith R.J., Gut adaptation and the insulin-like growth factor system: Regulation by glutamine and IGF-I administration, Am. J. Physiology., 1996, 271, 866–75
  • [7] Scott R.B., Kirk D., MacNaughton W.K., Meddings J.B., GLP-2 augments the adaptive response to massive intestinal resection in rat, Am. J. Physiol., 1998, 275, 911–21
  • [8] Warner B.W., Erwin C.R., Critical roles for EGF receptor signaling during resection-induced intestinal adaptation, J. Pediatr. Gastroenterol. Nutr., 2006, 43, S68–73 http://dx.doi.org/10.1097/01.mpg.0000226393.87106.da[Crossref]
  • [9] Alavi K., Kato Y., Yu D., Schwartz M.Z., Enteral glutamine does not enhance the effects of hepatocyte growth factor in short bowel syndrome, J. Pediatr. Surg., 1998, 33, 1666–9 http://dx.doi.org/10.1016/S0022-3468(98)90605-4[Crossref]
  • [10] Neves Jde S., de Aguilar-Nascimento J.E., Gomes-da-Silva M.H., Cavalcanti R.N., Bicudo A.S., Nascimento M., et al., Glutamine alone or combined with short-chain fatty acids fails to enhance gut adaptation after massive enterectomy in rats, Acta Cir. Bras., 2006, 21, Suppl 4, 2–7 [Crossref]
  • [11] Wilmore D.W., Glutamine and the gut, Gastroenterology, 1994, 107, 1885–6
  • [12] Windmueller H.G., Spaeth A.E., Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood, Arch. Biochem. Biophys., 1975, 171, 662–72 http://dx.doi.org/10.1016/0003-9861(75)90078-8[Crossref]
  • [13] Souba W.W., Herskowitz K., Austgen T.R., Chen M.K., Salloum R.M., Glutamine nutrition: theoretical considerations and therapeutic impact., JPEN J. Parenter. Enteral. Nutr., 1990, 14, 237–41 http://dx.doi.org/10.1177/014860719001400516[Crossref]
  • [14] Campos F.G., Waitzberg D.L., Logulo A.F., Mucerino D.R., Habr-Gama A., Importância da glutamina em nutriçao na prática clínica, Arq. Gastroenterol., 1996, 33, 86–92
  • [15] Cukier C., Waitzberg D.L., Borges V.C., Silva M.L.T., Rodrigues J.G., Pinotti H.W., Clinical use of growth hormone and glutamine in short-bowel syndrome, Rev. Hosp. Clin. Fac. Med. Sao. Paulo., 1999, 54, 29–34 [Crossref]
  • [16] Duran B., The effects of long-term total parenteral nutrition on gut mucosal immunity in children with short bowel syndrome: a systematic review, BMC Nurs., 2005, 4, 2 http://dx.doi.org/10.1186/1472-6955-4-2[Crossref]
  • [17] Li J., Kudsk K.A., Janu P., Renegar K.B., Effects of glutamine-enriched total parenteral nutrition on small intestinal gut-associated lymphoid tissue and upper respiratory tract immunity, Surgery, 1997, 121, 542–9 http://dx.doi.org/10.1016/S0039-6060(97)90109-4[Crossref]
  • [18] Scheppach W., Loges C., Bartram P., Christl S.U., Richter F., Dusel G., et al., Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon, Gastroenterology, 1994, 107, 429–34
  • [19] Vanderhoof J.A., Blackwood D.J., Mommadpour H., Park J.H., Effects of oral supplementation of glutamine on small intestinal mucosa following resection, J. Am. Coll. Nutr., 1992, 11, 223–7
  • [20] Michail S., Mohammadpour H., Park J.H., Vanderhoof J.A., Effect of glutamine-supplemented elemental diet on mucosal adaptation after small bowel resection in rats, JPEN J. Pediatr. Gastroenterol. Nutr., 1995, 21, 394–8 http://dx.doi.org/10.1097/00005176-199511000-00005[Crossref]
  • [21] Wiren M.E., Permert J., Skullman S.P., Wang F., Larsson J., No differences in mucosal adaptive growth one week after intestinal resection in rats given enteral glutamine supplementation or deprived of glutamine, Eur. J. Surg., 1996, 162, 489–98
  • [22] Scolapio J.S., Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled study, JPEN J. Parenteral. Enteral. Nutr., 1999, 23, 309–12 http://dx.doi.org/10.1177/0148607199023006309[Crossref]
  • [23] Scolapio J.S., Camilleri M., Fleming C.R., Oenning L.V., Burton D.D., Sebo T.J., et al., Effect of growth hormone, glutamine, and diet on adaptation in short-bowel syndrome: a randomized, controlled study, Gastroenterology, 1997, 113, 1074–81 http://dx.doi.org/10.1053/gast.1997.v113.pm9322500[Crossref]
  • [24] Matarese L.E., Seidner D.L., Steiger E., Growth hormone, glutamine, and modified diet for intestinal adaptation, J. Am. Diet. Assoc., 2004, 104, 1265–72 http://dx.doi.org/10.1016/j.jada.2004.05.202[Crossref]
  • [25] Ribeiro S.R., Pinto P.E. Jr., de Miranda A.C., Bromberg S.H., Lopasso F.P., Irya K., Weight loss and morphometric study of intestinal mucosa in rats after massive intestinal resection: influence of a glutamine-enriched diet, Rev. Hosp. Clin. Fac. Med. Sao Paulo, 2004, 59, 349–56
  • [26] Yang H., Larsson J., Permert J., Braaf Y., Wirén M., No effect of bolus glutamine supplementation on the postresectional adaptation of small bowel mucosa in rats receiving chow ad libitum, Dig. Surg., 2000, 17, 256–60 http://dx.doi.org/10.1159/000018844[Crossref]
  • [27] Zhou X., Li Y.X., Li N., Li J.S., Glutamine enhances the gut-trophic effect of growth hormone in rat after massive small bowel resection, J. Surg. Res., 2001, 99, 47–52 http://dx.doi.org/10.1006/jsre.2001.6108[Crossref]
  • [28] Terzi C., Sevinc A.I., Kocdor H., Oktay G., Alanyali H., Küpelioglu A., et al., Improvement of colonic healing by preoperative rectal irrigation with shortchain fatty acids in rats given radiotherapy, Dis. Colon Rectum, 2004, 47, 2184–94 http://dx.doi.org/10.1007/s10350-004-0724-7[Crossref]
  • [29] Reddy G.K., Enwemeka C.S., A simplified method for analysis of hydroxyproline in biological tissues, Clin. Biochem., 1996, 29, 225–9 http://dx.doi.org/10.1016/0009-9120(96)00003-6[Crossref]
  • [30] Williamson R.C.N., Intestinal adaptation: structural, functional, and cytokinetic changes, N. Engl. J. Med., 1978, 298, 1393–402
  • [31] Messing B., Crenn P., Beau P., Boutron-Ruault M.C., Rambaud J.C., Matuchansky C., et al., Longterm survival and parenteral nutrition dependence in adult patients with the short bowel syndrome, Gastroenterology, 1999, 117, 1043–50 http://dx.doi.org/10.1016/S0016-5085(99)70388-4[Crossref]
  • [32] Nygaard K., Resection of the small intestine in rats. III. Morphological changes in the intestinal tract, Acta Chir. Scand., 1967, 133, 233–48
  • [33] Vanderhoof J.A., Kollman K.A., Griffin S., Adrian T.E., Growth hormone and glutamine do not stimulate intestinal adaptation following massive small bowel resection in the rat, JPEN J. Pediatr. Gastroenterol. Nutr., 1997, 25, 327–31 http://dx.doi.org/10.1097/00005176-199709000-00016[Crossref]
  • [34] Kiyama T., Efron D.T., Tantry U., Barbul A., Effect of nutritional route on colonic anastomotic healing in the rat, J. Gasrointest. Surg., 1999, 3, 441–6 http://dx.doi.org/10.1016/S1091-255X(99)80062-6[Crossref]
  • [35] Thiesen A., Drozdowski L., Iordache C., Neo C.C., Woudstra T.D., Xenodemetropoulos T., et al., Adaptation following intestinal resection: mechanisms and signals, Best Pract. Res. Clin. Gastroenterol., 2003, 17, 981–95 http://dx.doi.org/10.1016/S1521-6918(03)00097-0[Crossref]
  • [36] Tapiero H., Mathé G., Couvreur P., Tew K.D., Glutamine and glutamate, Biomed Pharmacother., 2006, 56, 446–57 http://dx.doi.org/10.1016/S0753-3322(02)00285-8[Crossref]
  • [37] Alpers D.H., Is glutamine a unique fuel for small intestinal cells? Curr. Opin. Gastroenterol., 2000,16, 155–9 http://dx.doi.org/10.1097/00001574-200003000-00010[Crossref]
  • [38] Welters C.F., Dejong C.H., Deutz N.E., Heineman E., Intestinal function and metabolism in the early adaptive phase after massive small bowel resection in the rat, J. Pediatr. Surg., 2001, 36, 1746–51 http://dx.doi.org/10.1053/jpsu.2001.28813[Crossref]
  • [39] Lacey J.M., Wilmore D.W., Is glutamine a conditionally essential amino acid? Nutr. Rev., 1990, 48, 297–309
  • [40] Souba W.W., Intestinal glutamine metabolism and nutrition, J. Nutr. Biochem., 1993. 4, 2–9 http://dx.doi.org/10.1016/0955-2863(93)90013-M[Crossref]
  • [41] Windmueller H.G., Spaeth A.E., Identification of ketone bodies and glutamine as the major respiratory fuel in vivo for post-absorptive rat small intestine, J. Biol. Chem., 1978, 1078, 69–76
  • [42] Bristol J.B., Williamson R.C.N., Postoperative adaptation of the small intestine, World J. Surg., 1985, 9, 825–32 http://dx.doi.org/10.1007/BF01655386[Crossref]
  • [43] Irvin T.T., Hunt T.K., Effect of malnutrition on colonic healing, Ann. Surg., 1974, 180, 765–9 http://dx.doi.org/10.1097/00000658-197411000-00010[Crossref]
  • [44] Wang X. D., Jacobs D.O., O’Dwyer S.T., Smith R.J., Wilmore D.W., Glutamine-enriched parenteral nutrition prevents mucosal atrophy following massive small bowel resection, Surg. Forum, 1988, 39, 44–6
  • [45] Souba W.W., Smith R.J., Wilmore D.W., Glutamine metabolism by the intestinal tract, JPEN J. Parenteral. Enteral. Nutr., 1985, 9, 608–17 http://dx.doi.org/10.1177/0148607185009005608[Crossref]
  • [46] Klimberg V.S., Souba W.W., Salloum R.M., Holley D.T., Hautamaki R.D., Dolson D.J., et al., Intestinal glutamine metabolism after massive small bowel resection, Am. J. Surg., 1990, 159, 27–32 http://dx.doi.org/10.1016/S0002-9610(05)80603-8[Crossref]
  • [47] Landy H., Mouriel T., Darcy-Vrillon B., Darcy-Vrillon B., Vaugelade P., Blachier F., et al., Enterocyte metabolism during early adaptation after extensive intestinal resection in a rat model, Surgery, 2004, 135, 649–56 http://dx.doi.org/10.1016/j.surg.2003.11.013[Crossref]
  • [48] Waitzberg D.L., Cukier C., Mucerino D.R., Logulo A.F., Torrinhas R.S., de Castro I., Small bowel adaptation with growth hormone and glutamine after massive resection rat’small bowel, Nutr. Hosp., 1999, 14, 81–90
  • [49] Spadoni J.M., Aguilar-Nascimento J.E., Silva M.H., Spadoni-Neto B., Costa P.A., Alessio D.M., Effects of the combined use of glutamine and growth hormone in the intestinal adaptation after massive resection of the small bowel in rats, Acta Cir. Bras., 2005, 20, 382–9 http://dx.doi.org/10.1590/S0102-86502005000500008[Crossref]
  • [50] Gu Y., Wu Z.H., Xie J.X., Jin D.Y., Zhuo H.C., Effects of growth hormone (rhGH) and glutamine supplemented parenteral nutrition on intestinal adaptation in short bowel rats, Clin. Nutr., 2001, 20, 159–66 http://dx.doi.org/10.1054/clnu.2000.0379[Crossref]
  • [51] Luo M., Fernández-Estívariz C., Manatunga A.K., Bazargan N., Gu L.H., Jones D.P., et al., Are plasma citrulline and glutamine biomarkers of intestinal absorptive function in patients with short bowel syndrome? JPEN J. Parenter. Enteral. Nutr., 2007, 31, 1–7 http://dx.doi.org/10.1177/014860710703100101[Crossref]
  • [52] Byrne T.A., Wilmore D.W., Iyer K., Dibaise J., Clancy K., Robinson M.K., et al., Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial, Ann. Surg., 2005, 242, 655–61 http://dx.doi.org/10.1097/01.sla.0000186479.53295.14[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-008-0062-6
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.