Henoch-Schönlein purpura presenting with multiplex gastrointestinal manifestations and massive nephrotic syndrome in adulthood - a case report

• Autorzy: Farkas Klaudia , Molnár Tamás , Nagy Ferenc , Tiszlavicz László , Németh István , Kemény Éva , Varga Erika , Wittmann Tibor
• Języki publikacji: EN

Abstrakty

EN

Henoch-Schönlein purpura (HSP) is a systemic small vessel vasculitis mainly affecting children. We report a case of a 49-year-old woman with severe gastrointestinal and renal involvement of HSP. Endoscopy revealed more characteristic findings in the terminal ileum than in the gastric antrum. Histological examinations of the biopsy samples from the ileum, antrum, skin and kidney confirmed the diagnosis of HSP. Parenteral corticosteroid therapy led to a rapid improvement of the gastrointestinal symptoms, but because of the excessive proteinuria intravenous cyclophosphamide therapy had to be introduced.

Słowa kluczowe

EN

Henoch-Schönlein purpura; Nephrotic syndrome; Adulthood

• Czasopismo: Open Medicine
• Rocznik: 2008
• Tom: 3
• Numer: 4
• Strony: 521-524

Daty

wydano

2008-12-01

online

2008-10-22

Twórcy

autor

Farkas Klaudia

• First Department of Internal Medicine, University of Szeged, H6720, Szeged, Hungary

autor

Molnár Tamás

• First Department of Internal Medicine, University of Szeged, H6720, Szeged, Hungary,

autor

Nagy Ferenc

• First Department of Internal Medicine, University of Szeged, H6720, Szeged, Hungary

autor

Tiszlavicz László

• Department of Pathology, University of Szeged, H6720, Szeged, Hungary

autor

Németh István

• Department of Pathology, University of Szeged, H6720, Szeged, Hungary

autor

Kemény Éva

• Department of Pathology, University of Szeged, H6720, Szeged, Hungary

autor

Varga Erika

• Department of Dermatology and Allergology, University of Szeged, H6720, Szeged, Hungary

autor

Wittmann Tibor

• First Department of Internal Medicine, University of Szeged, H6720, Szeged, Hungary

Bibliografia

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• [3] Chen M.J., Wang T.E., Chang W.H. Tsai S.J., Liao W.S., Endoscopic findings in a patient with Henoch-Schönlein purpura, World J. Gastroenterol., 2005, 11, 2354–2356
• [4] Sharma A., Wanchu A., Kalra N., Singh S., Bambery P., Successful treatment of severe gastrointestinal involvement in adult-onset Henoch-Schönlein purpura, Singapore Med. J., 2007, 48, 1047–1050 [PubMed]
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• [6] Rieu P., Noel L.H., Henoch-Schönlein nephritis in children and adults. Morphological features and clinicopathological correlations, Ann. Med. Intern., 1999, 150, 151–159
• [7] Shenoy M., Bradbury M.G., Lewis M.A., Webb N.J., Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression, Pediatr. Nephrol., 2007, 22, 1717–1722 http://dx.doi.org/10.1007/s00467-007-0557-4[Crossref]
• [8] de Almeida J.L., Campos L.M.A., Paim L.B., Leone C., Koch V.H., Silva C.A., Renal involvement in Henoch-Schönlein purpura: a multivariate analysis of initial prognostic factors, J. Pediatr., 2007, 83, 259–266 http://dx.doi.org/10.2223/JPED.1638[Crossref][WoS]
• [9] Coppo R., Andrulli S., Amore A., Gianoglio B., Conti G., Peruzzi L., et al., Predictors of outcome in Henoch-Schönlein nephritis in chlidren and adults, Am. J. Kidney Dis., 2006, 47, 993–1003 http://dx.doi.org/10.1053/j.ajkd.2006.02.178[Crossref]

Identyfikatory

DOI

10.2478/s11536-008-0060-8