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2008 | 3 | 4 | 417-421
Tytuł artykułu

Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Pseudomonas aeruginosa is one of the most frequently isolated organisms from infected burn wounds and a significant cause of nosocomial infection and septic mortality among burn patients. In this animal study, three antiseptic agents which were Octenidine dihydrochloride (Octenisept®, Schülke & Mayr, Norderstedt, Germany), polyhexanide (Prontosan®, B. Braun, Melsungen AG, Germany) and povidon iodine (Betadine, Purdue Pharma L.P, Stamford, USA) were compared to assess the antiseptic effect of their applications on experimental burn wounds in in rats contaiminated with P. aeruginosa. All treatment modalities were effective against P. aeruginosa because there were significant differences between treatment groups and control groups. The mean eschar concentrations were not different between polyhexanide and povidon iodine groups, but there were significant differences between the octenidine dihydrochloride group and the other treatment groups, indicating that the Octenidine dihydrochloride significantly eliminated P. aeruginosa more effectively in the tissues compared to the to other agents. All treatment modalities were sufficient to prevent the P. aeruginosa invasion into the muscle and to cause systemic infection. In conclusion, Octenidine dihydrochloride is the most effective antiseptic agent in the treatment of the P. aeruginosa-contaminated burn wounds; Octenidine dihydrochloride can be considered as a treatment choice because of its peculiar ability of limit the frequency of replacing wound dressings.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
3
Numer
4
Strony
417-421
Opis fizyczny
Daty
wydano
2008-12-01
online
2008-10-22
Twórcy
autor
  • Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey , fatihuygur@hotmail.com
  • Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
autor
  • Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
  • Department of Microbiology and Clinical Microbiology, Gülhane Military Medical Academy and Medical Faculty, Haydarpaşa Training Hospital, 34668, Istanbul, Turkey
Bibliografia
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  • [5] Botzenhart K., Doring G., Ecology and epidemiology of Pseudomonas aeruginosa. In., M. Campo, editor. Pseudomonas aeruginosa as an Opportunistic Pathogen., New York, Plenum Press, 1993, 1–18
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  • [9] Herndon DN., editor.Herndon’s total burn care. 2nd ed. London, W.B. Saunders Co., 2001, p. 98–169
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  • [13] Ulkür E., Oncül O., Karagöz H., Celiköz B., Cavu§lu S., Comparison of silver-coated dressing (Acticoat), chlorhexidine acetate 0.5% (Bactigrass), and silver sulfadiazine 1% (Silverdin) for topical antibacterial effect in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats, J. Burn Care Rehabil., 2005, 26(5), 430–433 http://dx.doi.org/10.1097/01.bcr.0000176879.27535.09
  • [14] Kramer A. et al., Comparison of the toxicity of Lavasept and selected antiseptic agents, Hyg. Med., 1993, 18, 9–16
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  • [16] Sedlock DM., Bailey DM., Microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent, Antimicrob. Agents. Chemother., 1985, 28, 786–90 [PubMed]
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  • [18] Ikeda T., Tazuke S., Watanabe M., Interaction of biologically active molecules with phospholipid membranes, I. Fluorescence depolarization studies on the effect of polymeric biocide bearing biguanide groups in the main chain, Biochim. Biophys. Acta., 1983, 735, 380–6 http://dx.doi.org/10.1016/0005-2736(83)90152-9[Crossref]
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  • [20] Rietkötter J., Körber A., Grabbe S., Dissemond J., Eradication of methicillin-resistant Staphylococcus aureus in a chronic wound by a new polyhexanide hydrogel. J. Eur. Acad. Dermatol. Venereol., 2007 Nov, 21(10), 1416–7 http://dx.doi.org/10.1111/j.1468-3083.2007.02217.x[Crossref]
  • [21] Daeschlein G., Assadian O., Bruck JC., Meinl C., Kramer A., Koch Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds, SSkin. Pharmacol. Physiol., 2007, 20(6), 292–296 http://dx.doi.org/10.1159/000107577[Crossref][WoS]
  • [22] Burks RI., Povidone-iodine solution in wound treatment, Phys. Ther., 1998, 78, 212–218 [PubMed]
  • [23] Harvey SC., Antiseptics and disinfectants, In, Gilman AG., Goodman LS., Rall TW., Murad F., eds. The pharmacological basis of therapeutics, 7th ed. New York, Macmillian Publishing Co. Inc. 1985, 959–973
  • [24] LaRocca R., LaRocca MAK., Ansell JM., Microbiology of povidoneiodine, an oveniew. In, Digenis GA., Ansell JM., eds. Proceedings of the Intemational Symposium on Povidone. Lexington, Ky, College of Pharmacy, University of Kentucky, 1983, 101–119
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-008-0042-x
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