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2008 | 3 | 4 | 453-458
Tytuł artykułu

Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
We analyzed the clinicopathological features and survival rates of the patients with renal cell carcinoma younger than 50 years old. Between 2004 and 2007, 28 patients between 19–49 years underwent surgery for renal cell carcinoma. Presenting symptoms, type of the surgery performed, postoperative outcomes and duration of follow-up were recorded. Mean age was 41.5±7.6 years and 75% of patients were male. The tumor was symptomatic in 19(67.9%) and incidental in 9(32.1%) patients. Radical nephrectomy and nephron-sparing surgery were performed in 18(64.3%) and 10(35.7%) patients, respectively. The most common histologic type was clear cell(67.9%). The mean tumor diameters were 3.5±0.95 and 7.4±5.2 cm in the incidental and symptomatic groups, respectively(p=0.035). Incidentally discovered tumors and tumors treated by NSS did not include Fuhrman grade 4. There were no differences regarding pathological stage and Fuhrman grades when patients were grouped according to their symptomatology(p=0.242 and p=0.265, respectively). Overall mortality was 17.9%(n=5) whereas 4 patients(14.3%) died because of cancer. The mean survival was 30.6 months and cancer specific survival rate was 85.2%. Most of the tumors in this age group were symptomatic and most common histologic subtype was clear cell carcinoma. Incidentally discovered tumors had statistically significant lower tumor size.
Słowa kluczowe
Wydawca
Czasopismo
Rocznik
Tom
3
Numer
4
Strony
453-458
Opis fizyczny
Daty
wydano
2008-12-01
online
2008-10-22
Twórcy
autor
autor
  • Department Of Urology, Fatih Unıversıty Medical School, Ankara, Turkey
  • 1st Pathology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey
  • 1st Urology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey
autor
  • 1st Pathology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey
  • 1st Urology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey
autor
  • 1st Urology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey
Bibliografia
  • [1] Abou El Fettouh H.I., Cherullo E.E., El-Jack M., Al Maslamani Y., Novick A.C., Sporadic Renal cell carcinoma in young adults: presentation, treatment, and outcome, Urology., 2002, 60, 806–810 http://dx.doi.org/10.1016/S0090-4295(02)01884-8[Crossref]
  • [2] Denzinger S., Wolfgang O., Burger M., Hammerschmied C., Junker K., Hartman A., Wieland W.F., Walter B., Sporadic renal cell carcinoma in young and elderly patients:are there different clinicopathological features and disease specific survival rates?, World J Surg Oncol., 2007, 5,16 http://dx.doi.org/10.1186/1477-7819-5-16[Crossref]
  • [3] Yusim I., Mermershtain W., Neulander E., Eidelberg I., Gusakova I., Kaneti J., Influence of age on the prognosis of patients with renal cell carcinoma (rcc), Onkologie, 2002, 25, 548–550 http://dx.doi.org/10.1159/000068626[Crossref]
  • [4] Ljungberg B., Hanbury D.C., Kuczyk M.A., Merseburger A.S., Mulders P.F., Patard J.J., et al., Renal cell carcinoma guideline, Eur Urol., 2007, 51, 1502–1510 http://dx.doi.org/10.1016/j.eururo.2007.03.035[Crossref]
  • [5] Siemer S., Hack M., Lehmann J., Becker F., Stockle M., Outcome of renal tumors in young adults, J Urol, 2006, 175, 1240–1244 http://dx.doi.org/10.1016/S0022-5347(05)00696-8[Crossref]
  • [6] Taccoen X., Valeri A., Descotes J.L., Morin V., Stindel E., Doucet L., et al., Renal cell carcinoma in adults 40 years old or less: young age is an independent prognostic factor for cancer-specific survival, Eur Urol, 2007, 51, 980–987 http://dx.doi.org/10.1016/j.eururo.2006.10.025[Crossref]
  • [7] Eggener S.E., Rubenstein J.R., Smith N.D., Nadler R.B., Kontak J., Flanigan R.C., et al., Renal tumors in young adults, J Urol, 2004, 171, 106–110 http://dx.doi.org/10.1097/01.ju.0000099028.95679.52[Crossref]
  • [8] Sobin L.H., Wittekind C.H. (Eds.), International Union Against Cancer (UICC). TNM classification of malignant tumours, 6th ed., New York: Wiley-Liss, 2002, pp. 193–195
  • [9] Fuhrman S.A., Lasky L.C., Limas C, Prognostic significance of morphologic parameters in renal cell carcinoma, Am J Surg Pathol, 1982, 6,655–663 http://dx.doi.org/10.1097/00000478-198210000-00007[Crossref]
  • [10] Zugor V., Fridel S., Lausen B., Schott G.E., Kühn R., Labanaris A.P., renal cell carcinoma under 35 years of age: Comparison of survival rates for symptomatic and asymptomatic patients, Int Urol Nephrol (In Press), DOI:10.1007/s11255-007-9274-y [Crossref][WoS]
  • [11] Sanchez-Ortiz R.F., Rosser C.J., Madsen L.T., Swanson D.A., Wood C.G., Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma, J Urol, 2004, 171, 2160–2166 http://dx.doi.org/10.1097/01.ju.0000125487.96469.2e[Crossref]
  • [12] Goetzl M.A., Desai M., Mansukhani M., Goluboff E.T., Katz A.E., Sawczuk I.H., et al., Natural history and clinical outcome of sporadic renal tumors diagnosed in the young adult, Urology, 2004, 63, 41–45 http://dx.doi.org/10.1016/j.urology.2003.08.020[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-008-0038-6
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