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2007 | 2 | 4 | 447-457
Tytuł artykułu

Influence of cadmium and copper on tissue element levels of pregnant rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
In the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.
Słowa kluczowe
EN
Pregnancy   cadmium   copper   fetus   rat  
Wydawca

Czasopismo
Rocznik
Tom
2
Numer
4
Strony
447-457
Opis fizyczny
Daty
wydano
2007-12-01
online
2007-12-01
Twórcy
  • Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey, sturgut@pau.edu.tr
autor
  • Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
  • Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
  • Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
  • Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
  • Department of Biochemistry, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
autor
  • Department of Physiology, Faculty of Medicine, Pamukkale University, 20070, Denizli, Turkey
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-007-0047-x
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