PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
Czasopismo
2007 | 2 | 3 | 304-312
Tytuł artykułu

Cardiac valve calcifications and predictive parameters in hemodialysis patients

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Cardiac valvular calcification is frequent among hemodialysis (HD) patients. The presence of valvular calcification can help identify HD patients with a higher risk for cardiovascular diseases. Our aim was to determine the prevalence of valvular calcification (VC) in our maintenance hemodialysis (HD) population and to examine some possible etiologic factors for its occurrence. We studied forty-four patients on hemodialysis (23 women and 21 men; mean age 57 ± 18 year; mean HD duration 34 ± 28 months). Valvular calcification (VC) was observed in 21 patients (48%). Of these patients, 6 patients (13%) had mitral valvular calcification, 9 patients (20%) had aortic valvular calcification, and 6 patients (13%) had calcification of both valves. The patients with VC were older than patients without VC (66±14 vs. 50±18). The patients with aortic calcification had longer HD duration than others (48±29 vs. 27±24 months). Patients with VC had higher systolic and diastolic blood pressures than patients without VC. The patients with mitral calcification had higher C-reactive protein (CRP) levels (14 ± 13 vs. 7 ± 7). No significant differences were found with respect to calcium, phosphorus, parathyroid hormone, alkaline phosphatase and mean Ca × P product. Our study confirmed that there is an increased prevalence of VC in HD patients. Age is a risk factor for cardiac VC in HD patients. Longer HD duration was associated with aortic valve calcification. In addition, elevated level of CRP is associated with mitral valve calcification in HD patients.
Wydawca

Czasopismo
Rocznik
Tom
2
Numer
3
Strony
304-312
Opis fizyczny
Daty
wydano
2007-09-01
online
2007-05-03
Twórcy
  • Department of Cardiology, School of Medicine, Fatih University, 06540, Ankara, Turkey, yussel1971@hotmail.com
autor
  • Department of Internal Medicine, Division of Nephrology, School of Medicine, Fatih University, 06540, Ankara, Turkey
  • Department of Internal Medicine, Division of Nephrology, School of Medicine, Fatih University, 06540, Ankara, Turkey
autor
  • Department of Family Medicine, School of Medicine, Fatih University, 06540, Ankara, Turkey
autor
  • Department of Family Medicine, School of Medicine, Fatih University, 06540, Ankara, Turkey
autor
  • Department of Internal Medicine, Division of Nephrology, School of Medicine, Fatih University, 06540, Ankara, Turkey
autor
  • Department of Internal Medicine, Division of Nephrology, School of Medicine, Fatih University, 06540, Ankara, Turkey
Bibliografia
  • [1] G. Coen, M. Manni, D. Mantella and G. Splendiani: “Can cardiovascular calcifications be prevented in chronic kidney disease?”, G. Ital. Nefrol., Vol. 23, (2006), pp. 21–26.
  • [2] P. Jungers, T. Nguyen Khoa, Z.A. Massy, J. Zingraff, M. Labrunie, B. Descamps-Latscha and N.K. Man: “Incidence of atherosclerotic arterial occlusive accidents in predialysis and dialysis patients”, Nephrol. Dial. Transpl., Vol. 14, (1999), pp. 898–902. http://dx.doi.org/10.1093/ndt/14.4.898[Crossref]
  • [3] J. Braun, M. Oldendorf, W. Moshage, R. Heidler, E. Zeitler and F.C. Luft: “Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients”, Am. J. Kidney Dis., Vol. 27(3), (1996), pp. 394–401. [Crossref]
  • [4] R. Sharma, D. Pellerin, D.C. Gaze, R.L. Mehta, H. Gregson, C.P. Streather, P.O. Collinson and S.J.D. Brecker: “Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease”, Atherosclerosis, (2006).
  • [5] V. Panuccio, R. Tripepi, G. Tripepi, F. Mallamaci, F.A. Benedetto, A. Cataliotti, I. Bellanuova, G. Giacone, L.S. Malatino and C. Zoccali: “Heart valve calcifications, survival, and cardiovascular risk in hemodialysis patients”, Am. J. Kidney Dis., Vol. 43(3), (2004), pp. 479–484. http://dx.doi.org/10.1053/j.ajkd.2003.11.009[Crossref]
  • [6] A.Y. Wang, M. Wang, J. Woo, C.W. Lam, P.K. Li, S.F. Lui and J.E. Sanderson: “Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study”, J. Am. Soc. Nephrol., Vol. 14(1), (2003), pp. 159–168. http://dx.doi.org/10.1097/01.ASN.0000038685.95946.83[Crossref]
  • [7] G.A. Block, T.E. Hulbert-Shearon, N.W. Levin and F.K. Port: “Association of serum phosphorus and calcium × phosphate product with increased mortality in chronic hemodialysis patients: a national study”, Am. J. Kidney Dis., Vol. 31(4), (1998), pp.607–617. [Crossref]
  • [8] M. Ketteler, P. Bongartz, R. Westenfeld, J.E. Wildberger, A.H. Mahnken, R. Bohm, T. Metzger, C. Wanner, W. Jahnen-Dechent and J. Floege: “Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study”, Lancet, Vol. 361(9360),(2003), pp. 827–833. http://dx.doi.org/10.1016/S0140-6736(03)12710-9[Crossref]
  • [9] S. Mazzaferro, G. Coen, S. Bandini, P.P. Borgatti, M. Ciaccheri, D. Diacinti, E. Ferranti, T. Lusenti, G. Mancini and I. Monducci: “Role of ageing, chronic renal failure and dialysis in the calcification of mitral annulus”, Nephrol. Dial. Transpl., Vol. 8(4), (1993), pp. 335–340.
  • [10] E. Straumann, B. Meyer, M. Mitseli, A. Blumberg and H.R. Jenzer: “Aortic and mitral valve disease in patients with end stage renal failure on long term hemodialysis”, Brit. Heart J., Vol. 67(3), (1992), pp. 236–239. [Crossref]
  • [11] E.R. Maher, G. Young, B. Smyth-Walsh, S. Pugh and J.R. Curtis: “Aortic and mitral valve calcification in patients with end stage-stage renal disease”, Lancet, Vol. 330, (1987), pp. 875–877. http://dx.doi.org/10.1016/S0140-6736(87)91370-5[Crossref]
  • [12] E.R. Maher, M. Pazianas and J.R. Curtis: “Calcific aortic stenosis: a complication of chronic uremia”, Nephron, Vol. 42(2), (1987), pp. 119–122. http://dx.doi.org/10.1159/000184472[Crossref]
  • [13] A.Y. Wang, J. Woo, M. Wang, M.M. Sea, R. Ip, P.K. Li and J.E. Sanderson: “Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients”, J. Am. Soc. Nephrol., Vol. 12(9), (2001), pp. 1927–1936.
  • [14] P. Strozecki, G. Odrowaz-Sypniewska and J. Manitius: “Cardiac valve calcifications and left ventricular hypertrophy in hemodialysis patients”, Renal Failure, Vol. 27, (2005), pp. 733–738. http://dx.doi.org/10.1080/08860220500243296[Crossref]
  • [15] P. Raggi, A. Boulay, S. Chasan-Taber, N. Amin, M. Dillon, S.K. Burke and G.M. Chertow: “Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease?”, J. Am. Coll. Cardiol., Vol. 39(4), (2002), pp. 695–701. http://dx.doi.org/10.1016/S0735-1097(01)01781-8[Crossref]
  • [16] S. Ribeiro, A. Ramos, A. Brandao, J.R. Rebelo, A. Guerra, C. Resina, A. Vila-Lobos, F. Carvalho, F. Remedio and F. Ribeiro: “Cardiac valve calcification in hemodialysis patients: role of calcium-phosphate metabolism”, Nephrol. Dial. Transpl., Vol. 13, (1998), pp. 2037–2040. http://dx.doi.org/10.1093/ndt/13.8.2037[Crossref]
  • [17] C.S. Fox, M.G. Larson, R.S. Vasan, C.Y. Guo, H. Parise, D. Levy, E.P. Leip, C.J. O’donnell, R.B. D’Agostino and E.J. Benjamin: “Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study”, J. Am. Soc. Nephrol., Vol. 17(2), (2006) pp. 521–527. http://dx.doi.org/10.1681/ASN.2005060627[Crossref]
  • [18] M. Salgueira, C. Javara, R.M. Alba, J.R. Armas, N. Areste, A. Palma and J.A. Milan: “Valvular heart calcifications in hemodialysis patients: an analysis of predisposed factors”, Nefrologia, Vol. 18, (1998), pp. 221–226.
  • [19] D. Torun, S. Sezer, M. Baltali, F.U. Adam, A. Erdem, F.N. Ozdemir and M. Haberal: “Association of cardiac valve calcification and inflammation in patients on hemodialysis”, Renal Failure, Vol. 27, (2005), pp. 221–226.
  • [20] R.N. Foley, P.S. Parfrey, J.D. Harnett, G.M. Kent, D.C. Murray and P.E. Barre: “Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease”, Kidney Int., Vol. 49(5), (1996), pp. 1379–1385. http://dx.doi.org/10.1038/ki.1996.194[Crossref]
  • [21] S.G. Rostand and T.B. Drueke: “Parathroid hormone, vitamin D and cardiovascular disease in chronic renal failure”, Kidney Int., Vol. 56(2), (1999), pp. 383–392. http://dx.doi.org/10.1046/j.1523-1755.1999.00575.x[Crossref]
  • [22] N.W. Levin and N.A. Hoenich: “Consequences of hyperphosphatemia and elevated levels of the calcium-phosphorus product in dialysis patients”, Curr. Opin. Nephrol. Hy., Vol. 10(5), (2001), pp. 563–568. http://dx.doi.org/10.1097/00041552-200109000-00003[Crossref]
  • [23] T.D. Drüeke: “A clinical approach to the uremic patient with extraskeletal calcifications”, Nephrol. Dial. Transpl., Vol. 11, (1996), pp. 37–42. [Crossref]
  • [24] A. Tenenbaum, J. Shemesh, E.Z. Fisman and M. Motro: “Advanced mitral annular calcification is associated with severe coronary calcification on fast dual spiral computed tomography”, Invest. Radiol., Vol. 35(3), (2000), pp. 193–198. http://dx.doi.org/10.1097/00004424-200003000-00006[Crossref]
  • [25] J. Zimmermann, S. Herrlinger, A. Pruy, T. Metzger and C. Wanner: “Inflammation enhaces cardiovascular risk and mortality in hemodialysis patients”, Kidney Int., Vol. 55, (1999), pp. 648–658. http://dx.doi.org/10.1046/j.1523-1755.1999.00273.x[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-007-0026-2
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.