Simultaneous treatment with carbimazole and granulocyte-colony stimulating factor in a patient with thyrotoxicosis and carbimazole induced neutropenia

• Autorzy: Indrajit Talapatra , Vengal Nagareddy , Manju Bhavnani , David Tymms
• Języki publikacji: EN

Abstrakty

EN

We describe a patient who was admitted with uncontrolled thyrotoxicosis and carbimazole induced neutropenia. She required 80 mg of carbimazole daily. The patient declined radio-iodine treatment because she had a little child and wished to have thyroid surgery. She received four doses of filgrastim (Granulocyte-colony stimulating factor) which maintained the neutrophil count within a reasonable level while she continued to receive carbimazole to prepare her for surgery. After a curative subtotal thyroidectomy and discontinuation of the carbimazole, the patient’s white cell count remained normal. Subsequently the patient was euthyroid on levothyroxine replacement. Carbimazole should always be discontinued if neutropenia occurs but this case demonstrates that in exceptional circumstances filgrastim can be an effective therapy while continuing carbimazole in the short term.

Słowa kluczowe

EN

Neutropenia; thyrotoxicosis; granulocyte-colony stimulating factor

• Czasopismo: Open Medicine
• Rocznik: 2006
• Tom: 1
• Numer: 4
• Strony: 419-423

Daty

wydano

2006-12-01

online

2006-10-24

Twórcy

autor

Indrajit Talapatra

• Royal Albert Edward Infirmary, Wigan, WN1 2NN, UK,

autor

Vengal Nagareddy

• Royal Albert Edward Infirmary, Wigan, WN1 2NN, UK

autor

Manju Bhavnani

• Royal Albert Edward Infirmary, Wigan, WN1 2NN, UK

autor

David Tymms

• Royal Albert Edward Infirmary, Wigan, WN1 2NN, UK

Bibliografia

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• [5] G. Wilcox, R. Wong, P.J. Elliott, D.J. Topliss and J.R. Sockigt: “Recovery from Carbimazole-Induced Aplastic Anaemia”, Int. J. Endocrinol. Metab., Vol. 1, (2003), pp. 41–43
• [6] D. Usha, D.M. Thatte and S.A. Dahanukar: “Therapeutic potential of the haematopoietic growth factors”, J. Postgrad. Med., Vol. 40(4), (1994), pp. 210–15
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Identyfikatory

DOI

10.2478/s11536-006-0036-5