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2006 | 1 | 4 | 348-355
Tytuł artykułu

Hypolipidemic effect of a pro-drug containing nicotinic acid in rats

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We studied the release of nicotinic acid from a macromolecular pro-drug containing niacin bound to a polymeric support of dextran. Using a modified High-performance Liquid Chromatography (HPLC) method to provide an improved separation between nicotinic acid and its metabolites, we compared the plasma levels of nicotinic acid 24 h after administration of the pro-drug or a similar dose of unbound nicotinic acid to rats. Nicotinic acid exerts a number of pharmacological activities among which is the hypolipidemic effect. To determine the hypolipidemic effect of the pro-drug, we measured the triglyceride levels and examined the correlation with the plasma levels of nicotinic acid.Starting 6 h after administration of the pro-drug, the plasma levels of nicotinic acid were high enough to cause a decrease in the triglyceride level. These results suggest that nicotinic acid was gradually released from the polymeric support, leading to the sustained presence of the active substance and, therefore, a reduction in the level of triglycerides.

Opis fizyczny
  • Department of Biochemistry, University of Medicine and Pharmacy, Iasi, Romania,
  • Department of Pharmacology, University of Medicine and Pharmacy, Iasi, Romania
  • Department of Biochemistry, University of Medicine and Pharmacy, Iasi, Romania
  • Institute of Public Health “M. Ciuca”, Iasi, Romania
  • Institute of Macromolecular Chemistry “P. Poni”, Iasi, Romania
  • Department of Biochemistry, University of Medicine and Pharmacy, Iasi, Romania
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