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2006 | 1 | 4 | 356-369
Tytuł artykułu

Factors of lowered respiratory CO2 sensitivity by acetazolamide in anaesthetized rabbits

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The carbonic anhydrase (CA) inhibitor acetazolamide is a classic drug to treat patients with breathing disorders. Recent studies in rabbits showed that low-dose acetazolamide (not causing appreciable inhibition of red cell CA) significantly weakened respiratory muscle performance, accompanied by diminished ventilatory CO2-sensitivity, which implies stabilizing loop-gain properties. Now is aimed to explore the interaction of these factors under conditions of complete CA-inhibition by acetazolamide in a higher dose-range. In anesthetized rabbits (N=7), acetazolamide (up to 75 mg·kg−1) distinctly lowered the base excess (to-7.6 ± 0.9mM, mean ± SEM) without respiratory compensation of arterial pH. Ventilatory CO2-sensitivity was nearly abolished to 15.1 ± 5.2% of control, but the transmission of a CO2-mediated rise in tidal phrenic activity into respiratory work was only reduced by 51.6 ± 6.4%, P < 0.001, not very much more than (~38%) already observed at low-doses. Thus, the large reduction of ventilatory CO2-sensitivity in the high-dose range cannot be ascribed to respiratory muscle weakening, but rather may relate to complete inhibition of red cell CA. Conversely, CA-inhibition may not be the only cause for the weakening effect of acetazolamide on (respiratory) muscles. Adverse effects on respiratory muscles, impaired CO2-transport and acid-base imbalance may limit to make use of stabilizing effects on breathing control functions by high-dose acetazolamide.
Wydawca
Czasopismo
Rocznik
Tom
1
Numer
4
Strony
356-369
Opis fizyczny
Daty
wydano
2006-12-01
online
2006-10-24
Twórcy
autor
  • Department of Physiology and Anesthesiology, Leiden University Medical Center, 2300, RC Leiden, The Netherlands
autor
  • Department of Physiology, Faculty of Medicine, Ruhr-University, 44780, Bochum, Germany
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0034-7
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