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2006 | 1 | 3 | 228-236
Tytuł artykułu

Relationship of Anti-vimentin antibodies to anti-endothelial antibodies

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The intermediate filament protein vimentin is a potential target antigen for autoantibodies in some infectious and autoimmune diseases. Because endothelial cells contain an extensive interconnecting cytoplasmic network of vimentin, we examined the relationship between anti-vimentin and anti-endothelial cell antibodies (AECAs). We measured the level of anti-vimentin antibodies in patients with systemic autoimmune diseases (n=42), healthy blood donors (n=58), and patients with acute inflammation and showing anti-vimentin immunofluorescence (n=50). AECAs were detected by indirect immunofluorescence in human umbilical vein endothelial cells. Anti-vimentin antibodies were detected by indirect immunofluorescence in HEp-2 cells, and levels of anti-vimentin antibodies were measured using an enzyme-linked immunosorbent assay. We did not find significant differences in anti-vimentin levels between AECA-positive and-negative samples for any of the groups; however, serum anti-vimentin antibody levels were significantly higher in patients with acute non-autoimmune inflammatory diseases than in patients with systemic autoimmune diseases or healthy controls. There were no differences between the levels of anti-vimentin antibodies between patients with systemic autoimmune diseases and healthy individuals. The anti-vimentin antibodies levels also did not correlate with the AECA positivity.
Wydawca
Czasopismo
Rocznik
Tom
1
Numer
3
Strony
228-236
Opis fizyczny
Daty
wydano
2006-09-01
online
2006-09-01
Twórcy
  • Institute of Clinical Biochemistry and Laboratory Diagnostics, General Faculty Hospital and First Faculty of Medicine, Charles University, 120 00, Prague, Czech Republic
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0028-5
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