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2006 | 1 | 3 | 237-249
Tytuł artykułu

Aspirin and statin medication decreases the risk of myocardial infarction associated with LTA and NFKBIL1 polymorphisms

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Lymphotoxin-α (LTA) is a cytokine involved in inflammatory reactions. NFKBIL1 is a regulator of the NF-κB complex. The study investigated the associations of LTA 804 C>A and NFKBIL1-63 T>A polymorphisms with the use of statin and acetylsalicylic acid (ASA) treatment in relation to myocardial infarction (MI). The study population comprised of 600 Finnish individuals who underwent coronary angiography volunteering for the Angiography and Genes Study. Genotypes were detected by the TaqMan 5′ nuclease assay. We found a interaction between the LTA genotype (p=0.002) and the NFKBIL1 genotype (p=0.012) and statin treatment in relation to MI. Subjects with the LTA AA or the NFKBIL1 AA genotype were at a 2.77 (95% CI:1.22-6.24) and 2.85 (95% CI:1.22-6.66) times higher risk, respectively, of suffering an MI when compared to other genotypes among statin non-users. ASA treatment also modulated associations between LTA and NFKBIL1 genotypes and MI (p=0.015 and p=0.028 respectively). The NFKBIL1-A-LTA-A haplotype showed a 61% increase in the risk of MI compared to the NFKBIL1-T-LTA-C haplotype among statin non-users. Anti-inflammatory medication modifies the genotype-related risk of MI, suggesting that subjects with LTA and NFKBIL1 AA haplotype might especially benefit from the treatment.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
3
Strony
237-249
Opis fizyczny
Daty
wydano
2006-09-01
online
2006-08-27
Twórcy
  • Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University of Tampere, Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
autor
  • Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University of Tampere, Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
  • Heart Centre Department of Cardio-thoracic Surgery, Tampere University Hospital and Tampere University Medical School, Tampere, Finland
autor
  • Heart Centre Department of Cardio-thoracic Surgery, Tampere University Hospital and Tampere University Medical School, Tampere, Finland
autor
  • Heart Centre Department of Cardiology, Tampere University Hospital, Tampere, Finland
autor
  • Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University of Tampere, Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
  • Department of Forensic Medicine, University of Tampere, Medical School and Research Unit of the Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
  • Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, University of Tampere, Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland, terho.lehtimaki@uta.fi
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0026-7
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