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Czasopismo
2006 | 1 | 2 | 119-127
Tytuł artykułu

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of basocellular carcinomas. In spinocellular carcinomas, HBGAs were detected in tumor keratinocytes and in keratin pearls. These results provide new evidence for the differential expression of LAMPs and HBGAs in the normal stratified squamous epithelium, as well as the presence of a modulating reactivity in basocellular and spinocellular carcinomas, suggesting that these glycoproteins are involved in differentiation and tumorigenesis of human skin.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
2
Strony
119-127
Opis fizyczny
Daty
wydano
2006-06-01
online
2006-06-01
Twórcy
  • Department of Medical Biology, Medical University of Plovdiv, Plovdiv, 4000, Bulgaria, sarafian@abv.bg
autor
  • Service d’Anatomie et de Cytologie Pathologiques, Centre Hospitalier de Lagny-Marne-La-Vallée, Lagny-sur-Marne, 77495, France
  • Department of General and Clinical Pathology, Medical University of Pleven, Pleven, 6500, Bulgaria
Bibliografia
  • [1] C.M. Chuong, B.J. Nickoloff, P.M. Elias et al.: “What is the ‘true’ function of skin?”, Exp. Derm., Vol. 11, (2002), pp. 159–187. http://dx.doi.org/10.1034/j.1600-0625.2002.00112.x[Crossref]
  • [2] R.D. Moreno: “Differential expression of lysosomal associated membrane protein (LAMP-1) during mammalian spermiogenesis”, Mol. Reprod. Dev., Vol. 66, (2003), pp. 202–209. http://dx.doi.org/10.1002/mrd.10342[Crossref]
  • [3] K. Furuta, M. Ikeda, Y. Nakayama, K. Nakamura, M. Tanaka, N. Hamasaki, M. Himeno, S.R. Hamilton and J.T. August: “Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases”, Am. J. Pathol., Vol. 159, (2001), pp. 449–455. [Crossref]
  • [4] B.M. Kunzli, P.O. Berberat, Z.W. Zhu, M. Martignoni, J. Kleeff, A.A. Tempia-Caliera, M. Fukuda, A. Zimmermann, H. Friess and M.W. Buchler: “Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma”, Cancer, Vol. 94, (2002), pp. 228–239. http://dx.doi.org/10.1002/cncr.10162[Crossref]
  • [5] V.S. Sarafian, M. Jadot, J.M. Foidart, J.J. Letesson, F. van den Brule, V. Castronovo, R. Wattiaux, S. Wattiaux-De Coninck: “Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells”, Int. J. Cancer, Vol. 75, (1998), pp. 105–111. http://dx.doi.org/10.1002/(SICI)1097-0215(19980105)75:1<105::AID-IJC16>3.0.CO;2-F[Crossref]
  • [6] V. Ravn and E. Dabelsteen: “Tissue distribution of histo-blood group antigens”, Acta Pathol., Microbiol. Immunol. Scand., Vol. 108, (2000), pp. 1–28. [Crossref]
  • [7] K.H. Nomura, R. Kobayashi, Y. Hirabayashi, M. Fujisue-Sakai, S. Mizuguchi and K. Nomura: “Involvement of blood-group-B-active trisaccharides in Ca2+-dependent cell-cell adhesion in the Xenopus blastula”, Dev. Genes and Evolution, Vol. 208, (1998), pp. 9–18. http://dx.doi.org/10.1007/s004270050148
  • [8] J. Le Pendu, S. Marionneau, A. Cailleau-Thomas, J. Rocher, B. Le Moullac-Vaidye and M. Clement: “ABH and Lewis histo-blood group antigens in cancer”, Acta Pathol., Microbiol. Immunol. Scand., Vol. 109, (2001), pp. 9–31.
  • [9] V.S. Sarafian, E. Tomova and S. Kalaydjiev: “Stomach expression of histo-blood group antigens A and B in some vertebrates”, Acta Zool., Vol. 85, (2004), pp. 191–199. http://dx.doi.org/10.1111/j.0001-7272.2004.00170.x[Crossref]
  • [10] B.J. Nickoloff, J.Z. Qin, V. Chaturvedi, P. Bacon, J. Panella and M.F. Denning: “Life and death signaling pathways contributing to skin cancer”, J. Invest. Dermatol., Symposium Proceedings, Vol. 7, (2002), pp. 27–35. http://dx.doi.org/10.1046/j.1523-1747.2002.19633.x[Crossref]
  • [11] V. Ravn and E. Dabelsteen: “Tissue distribution of histo-blood group antigens”, APMIS, Vol. 108, (2000), pp. 1–28. http://dx.doi.org/10.1034/j.1600-0463.2000.d01-1.x[WoS][Crossref]
  • [12] U. Mandel, T. White, J. Karkov, S. Hakomori, H. Clausen and E. Dabelsteen: “Expression of the histo-blood group ABO gene defined glycosyltransferases in epithelial tissues”, J. Oral Pathol. Med., Vol. 19, (1990), pp. 251–256. http://dx.doi.org/10.1111/j.1600-0714.1990.tb00836.x[Crossref]
  • [13] H. Buth, B. Wolters, B. Hartwig, R. Meier-Bornheim, H. Veith, M. Hansen, C.P. Sommerhoff, N. Schaschke, W. Machleidt, N.E. Fusenig, P. Boukamp, K. Brix: “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”, Eur. J. Cell Biol., Vol. 83, (2004), pp. 781–795. http://dx.doi.org/10.1078/0171-9335-00428[Crossref]
  • [14] D.J. Tobin, K. Foitzik, T. Reinheckel, L. Mecklenburg, V.A. Botchkarev, C. Peters and R. Paus: “The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling”, Am. J. Pathol., Vol. 160, (2002), pp. 1807–1821. [Crossref]
  • [15] V.S. Sarafian, P. Dimova, I. Georgiev and H. Taskov: “ABH blood group antigen significance as markers of endothelial differentiation of mesenchymal cells”, Folia Med., Vol. 2, (1997), pp. 5–9.
  • [16] S. Gao, E.P. Bennett, J. Reibel, X. Chen, M.E. Christensen, A. Krogdahl and E. Dabelsteen: “Histo-blood group ABO antigen in oral potentially malignant lesions and squamous cell carcinoma-genotypic and phenotypic characterization”, Acta Pathol., Microbiol. Immunol. Scand., Vol. 112, (2004), pp. 11–20. [Crossref]
  • [17] E. Dabelsteen and S. Gao: “ABO blood-group antigens in oral cancer”, J. Dent. Res., Vol. 84, (2005), pp. 21–28. http://dx.doi.org/10.1177/154405910508400103[Crossref]
  • [18] P.D. Toto and H. Nadimi: “Coexpression of cytokeratins, involucrin, and blood group antigens in oral squamous cell carcinomas”, Oral Surgery, Oral Med., Oral Pathol., Vol. 90, (1990), pp. 75–80. http://dx.doi.org/10.1016/0030-4220(90)90182-R[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0012-0
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