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2006 | 1 | 1 | 87-98
Tytuł artykułu

Multiple primary malignant neoplasms - case report

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The synchronous occurence of primary carcinomas of endometrium and ovary is well recognized. Malignant peripheral nerve sheath tumours (MPNSTs) may also rarely occur in patients diagnosed with malignancies of the female genital tract. We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal MPNST. Ascites cytology and endometrial biopsy, followed by hysterectomy and bilateral adnexectomy, were performed to remove the synchronous tumors. Histology was suggestive of synchronous endometrial endometrioid carcinoma and ovarian mucinous adenocarcinoma. After the removal of the retroperitoneal tumor, a MPNST was diagnosed by immunohistochemistry. The patient developed two consecutive vaginal tumors diagnosed as metastases of the previously diagnosed endometrial carcinoma. Although synchronous tumors of endometrium and ovary were relatively early staged and consequently had a favorable prognosis, subsequently occuring implants along the lower genital tract and the metachronous MPNST added up to a poor prognosis.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
1
Strony
87-98
Opis fizyczny
Daty
wydano
2006-03-01
online
2006-03-01
Twórcy
autor
  • Pathology Department, University of Medicine and Pharmacy Iasi, Romania
  • Pathology Laboratory, Military Hospital Iasi, Romania
  • Obstetrics and Gynecology Department, University of Medicine and Pharmacy Iasi, Romania
  • Obstetrics and Gynecology Department, University of Medicine and Pharmacy Iasi, Romania
  • Pathology Department, University of Medicine and Pharmacy Iasi, Romania
Bibliografia
  • [1] G.J. Beattie, J.R. Livingstone, M.A. Cornbleet, J.F. Smyth and K.M. McLaren: “Mucinous endometrial carcinoma in a patient with previous ovarian endometrioid adenocarcinoma presenting some 18 years after initial bilateral ovariectomy: a case report”, Scott. Med. J., Vol. 36(6), (1991), pp. 181–182.
  • [2] C.D.M. Fletcher (Ed.): Diagnostic Histopathology of Tumors, Vol. 2, Churchill Livingstone, Edinburgh, 2000.
  • [3] P. Kleiheus and W.K. Cavenee (Eds.): WHO Classification of Tumors, Pathology and Genetics of Tumors of the Nervous System, IARC Press, Lyon, 2000.
  • [4] R.J. Kurman (Ed.): Blaustein’s Pathology of the Female genital Tract, 5th ed., Springer-Verlag, New York, 2002. [WoS]
  • [5] K.R. Lee and R.E. Scully: “Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with „pseudomyxoma peritonei“”, Am. J. Surg. Pathol., Vol. 24, (2000), pp. 1447–1464. http://dx.doi.org/10.1097/00000478-200007000-00018[Crossref]
  • [6] K.R. Lee and R.H. Young: “The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases”, Am. J. Surg. Pathol., Vol. 27, (2003), pp. 281–293. http://dx.doi.org/10.1097/00000478-200303000-00001[Crossref]
  • [7] R.L. Levine, C.B. Cargile, M.S. Blazes, B. van Rees, R.J. Kurman and L.H. Ellenson: “PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma”, Cancer Res., Vol. 58, (1998), pp. 3254–3258.
  • [8] M. Mandai, I. Konishi, H. Kuroda, T. Komatsu, S. Yamamoto, K. Nanbu, K. Matsushita, M. Fukumoto, H. Yamabe and T. Mori: “Heterogenous distribution of K-ras mutated epithelia in mucinous ovarian tumors with special reference to histopathology”, Hum. Pathol., Vol. 29, (1998), pp. 34–40. http://dx.doi.org/10.1016/S0046-8177(98)90387-2[Crossref]
  • [9] C. Mawrin, E. Kirches, C. Boltze, K. Dietzmann, A. Roessner and R. Schneider-Stock: “Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors”, Virchows Arch Springer-Verlag, Vol. 440(6), (2002), pp. 610–615. http://dx.doi.org/10.1007/s00428-001-0550-4
  • [10] G.L. Mutter: “Pten, a protean tumor suppressor”, Am. J. Pathol., Vol. 158, (2001), pp. 1895–1898.
  • [11] G.L. Mutter, T.A. Ince, J.P. Baak, G.A. Kust, X.P. Zhou and C. Eng: “Molecular identification of latent precancers in histologically normal endometrium”, Cancer Res., Vol. 61, (2001), pp. 4311–4314.
  • [12] R.R. Raju, W.R. Hart, D.K. Magnuson, J.R. Reid and D.G. Rogers: “Genital tract tumors in Proteus syndrome: report of a case of bilateral paraovarian endometrioid cystic tumors of borderline malignancy and review of the literature”, Mod. Pathol., Vol. 15(2), (2002), pp. 172–180. http://dx.doi.org/10.1038/modpathol.3880510[Crossref]
  • [13] F.A. Tavassoli and P. Deville (Eds.): WHO Classification of Tumors of the Breast and Female Genital Organs, IARC Press, Lyon, 2003.
  • [14] J.D. Woodruff and C.G. Julian “Multiple malignancy in the upper genital canal”, Am. J. Obstet. Gynecol., Vol. 103, (1969), pp. 810–822.
  • [15] R. Zaino, C. Whitney, M.F. Brady, K. DeGeest, R.A. Burger and R.E. Buller: “Simultaneously detected endometrial and ovarian carcinomas-a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study”, Gynecol. Oncol., Vol. 83(2), (2001), pp. 355–362. http://dx.doi.org/10.1006/gyno.2001.6400[Crossref]
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0004-0
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