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2006 | 1 | 1 | 2-11
Tytuł artykułu

Changes of the expression of insulin-like growth factor 1 and its two receptors in the periphery of the developing lung are parallel to ultrastructural capillary changes during perinatal period

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Insulin-like growth factor type 1 (IGF-1) belongs to the peptide hormones which regulate cell proliferation and differentiation as well as angiogenesis. The aim of the present study was the quantitative evaluation of immuohistochemical (IH) expression of IGF-1 and its two receptors (IGF-1Rα and IGF-1Rβ) parallel to changes of capillary lumen/whole capillary area (L/W) ratio during the perinatal period. Tissue samples from lungs from 19-, and 21-day fetuses as well as 1-, 3-, 5-day old newborns were processed for frozen sections that were used for IH staining and then used for quantitative analysis of antigens expression. In parallel, tissue samples were processed for transmission electron microscopy and used for capillaries morphometry. Our results were statistically evaluated. We found that the expression of IGF-1 in the peripheral part of the developing lung has a peak at the moment of birth when changes of vascular structure were reflected by L/W ratio. This is followed by the peak expression of the IGF-1Rα, but not of the IGF-1Rβ.
Wydawca

Czasopismo
Rocznik
Tom
1
Numer
1
Strony
2-11
Opis fizyczny
Daty
wydano
2006-03-01
online
2006-03-01
Twórcy
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland, amars@amp.edu.pl
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
autor
  • Department of Pathology, Oita Medical University, Oita, Japan
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
  • Intensive Care Unit, Collegium Medicum Jagiellonian University, Kraków, Poland
  • Department of Pathology, Oita Medical University, Oita, Japan
Bibliografia
  • [1] P.H. Buri: “The post natal growth of the rat lung. III. Morphology”, Anat. Rec. Vol. 180, (1974), pp. 77–98. http://dx.doi.org/10.1002/ar.1091800109[Crossref]
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  • [11] L.D. Wallen, W. Myint, K. Nygard, S. Shimasaki, D.R. Clemmons and V.K.M. Han: “Cellular distribution of insulin-like growth factor binding protein mRNA and peptides during rat lung development”, J. Endocrinol. Vol. 155, (1997), pp. 313–327. http://dx.doi.org/10.1677/joe.0.1550313[Crossref]
  • [12] A. Marszalek, T. Daa, K. Kashima, I. Nakayama and S. Yokoyama: “Expression of vascular endothelial growth factor and its receptors in the developing rat lung”, Jpn. J. Physiol. Vol. 51, (2001), pp. 313–318. http://dx.doi.org/10.2170/jjphysiol.51.313[Crossref]
  • [13] S. Buch, R.N. Han, J. Cabacungan, J. Wang, S. Yuan, R. Belcastro, J. Deimling, R. Jankov, X. Luo, S.J. Lye, M. Post and A.K. Tanswell: “Changes in expression of platelet-derived growth factor and its receptors in the lungs of newborn rats exposed to air or 60 % O(2)”, Pediatr. Res. Vol. 48, (2000), pp. 423–433.
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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