Self-regulating genes. Exact steady state solution by using Poisson representation

• Autorzy: István Sugár , István Simon
• Języki publikacji: EN

Abstrakty

EN

Systems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410–422) one can build the system itself from modules like this.

Słowa kluczowe

EN

genetics; master equations; Poisson representation; probability distribution

• Czasopismo: Open Physics
• Rocznik: 2014
• Tom: 12
• Numer: 9
• Strony: 615-627

Daty

wydano

2014-09-01

online

2014-07-31

Twórcy

autor

István Sugár

• Department of Neurology and Center for Translational Systems Biology, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA,

autor

István Simon

• Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary,

Bibliografia

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• [5] A. F. Ramos et al., Iet Systems Biology 4, 311 (2010) http://dx.doi.org/10.1049/iet-syb.2010.0058[Crossref]
• [6] C. W. Gardiner, Stochastic Methods: A Handbook for the Natural and Social Sciences (Springer, Berlin, 2004), Series in Synergetics.
• [7] M. Abramowitz, I. A. Sregun, Handbook of Mathematical Functions (National Bureau of Standards, 1972).

Identyfikatory

DOI

10.2478/s11534-014-0497-0