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2011 | 9 | 5 | 1372-1378
Tytuł artykułu

Analytical investigation of various regimes of retrograde trafficking of neurotropic viruses in axons

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A model of retrograde axonal transport of neurotropic viruses is developed. The model accounts for active viral transport by dynein motors as well as for passive transport by diffusion; the destruction of the virus as it propagates toward the neuron soma is modeled utilizing a first-order decay rate process. The effect of a limited time during which the axonal synapse is exposed to the virus is incorporated. An analytical solution is obtained. The obtained solution makes it possible to identify four different regimes of viral transport in the axon that correspond to the following situations: (1) Small viral diffusivity and small rate of viral destruction; (2) Large viral diffusivity and small rate of viral destruction; (3) Small viral diffusivity and large rate of viral destruction; (4) Large viral diffusivity and large rate of viral destruction. Characteristic features of these regimes are discussed.
Wydawca

Czasopismo
Rocznik
Tom
9
Numer
5
Strony
1372-1378
Opis fizyczny
Daty
wydano
2011-10-01
online
2011-09-15
Twórcy
  • Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC, 27695-7910, USA, avkuznet@eos.ncsu.edu
Bibliografia
  • [1] L.S.B. Goldstein, Z.H. Yang, Annu. Rev. Neurosci. 23, 39 (2000) http://dx.doi.org/10.1146/annurev.neuro.23.1.39[Crossref]
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  • [17] E.L.F. Holzbaur, In: P. St. George-Hyslop et al. (Eds.), Intracellular Trafficand Neurodegenerative Disorders (Springer, Berlin, 2009) 27 http://dx.doi.org/10.1007/978-3-540-87941-1_3[Crossref]
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11534-011-0051-2
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