Non-coding RNAs and a layered architecture of genetic networks

• Autorzy: Vladimir Zhdanov
• Języki publikacji: EN

Abstrakty

EN

In eukaryotic cells, protein-coding sequences constitute a relatively small part of the genome. The rest of the genome is transcribed to non-coding RNAs (ncRNAs). Such RNAs form the cornerstone of a regulatory network that operates in parallel with the protein network. Their biological functions are based primarily on the ability to pair with and deactivate target messenger RNAs (mRNAs). To clarify the likely role of ncRNAs in complex genetic networks, we present and comprehensively analyze a kinetic model of one of the key counterparts of the network architectures. Specifically, the genes transcribed to ncRNAs are considered to interplay with a hierarchical two-layer set of genes transcribed to mRNAs. The genes forming the bottom layer are regulated from the top and negatively self-regulated. If the former regulation is positive, the dependence of the RNA populations on the governing parameters is found to be often non-monotonous. Specifically, the model predicts bistability. If the regulation is negative, the dependence of the RNA populations on the governing parameters is monotonous. In particular, the population of the mRNAs, corresponding to the genes forming the bottom layer, is nearly constant.

Słowa kluczowe

EN

subcellular processes; mRNA and ncRNA synthesis; degradation and association; nonlinear dynamics; mean-field kinetic equations; bistability

• Czasopismo: Open Physics
• Rocznik: 2010
• Tom: 8
• Numer: 6
• Strony: 864-872

Daty

wydano

2010-12-01

online

2010-09-05

Twórcy

autor

Vladimir Zhdanov,

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Identyfikatory

DOI

10.2478/s11534-010-0025-9