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Czasopismo
2009 | 7 | 3 | 541-548
Tytuł artykułu

Evolutionary dynamics of imatinib-treated leukemic cells by stochastic approach

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The evolutionary dynamics of a system of cancerous cells in a model of chronic myeloid leukemia (CML) is investigated by a statistical approach. Cancer progression is explored by applying a Monte Carlo method to simulate the stochastic behavior of cell reproduction and death in a population of blood cells which can experience genetic mutations. In CML front line therapy is represented by the tyrosine kinase inhibitor imatinib which strongly affects the reproduction of leukemic cells only. In this work, we analyze the effects of a targeted therapy on the evolutionary dynamics of normal, first-mutant and cancerous cell populations. Several scenarios of the evolutionary dynamics of imatinib-treated leukemic cells are described as a consequence of the efficacy of the different modelled therapies. We show how the patient response to the therapy changes when a high value of the mutation rate from healthy to cancerous cells is present. Our results are in agreement with clinical observations. Unfortunately, development of resistance to imatinib is observed in a fraction of patients, whose blood cells are characterized by an increasing number of genetic alterations. We find that the occurrence of resistance to the therapy can be related to a progressive increase of deleterious mutations.
Wydawca

Czasopismo
Rocznik
Tom
7
Numer
3
Strony
541-548
Opis fizyczny
Daty
wydano
2009-09-01
online
2009-06-25
Twórcy
  • Dipartimento di Fisica e Tecnologie Relative, Università di Palermo and CNISM-INFM, Viale delle Scienze, edificio 18, I-90128, Palermo, Italy
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11534-009-0020-1
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