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2008 | 6 | 1 | 38-44
Tytuł artykułu

Synergy of feedback mechanisms in gene regulation systems with promoter and repressor transcription factors

Autorzy
Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Presence of feedback mechanisms, both positive and negative, in the gene regulation systems is generally appreciated. The present study proposes a diagrammatic representation of these phenomena that affords their exact formulation and reveals some new facts. Topology of feedback relationships is defined by diagram configuration and quantitative evaluation is afforded by analytical apparatus coming with the diagrams. In particular, criterion for occurrence of bistability and synergy of positive and negative feedback are described in exact manner using the concept of transmission functions associated with diagram edges. The approach is demonstrated on genetic regulatory system comprising two genes whose transcription is controlled by activator and repressor proteins mutually competing for binding to the same responsive element of the DNA.
Wydawca

Czasopismo
Rocznik
Tom
6
Numer
1
Strony
38-44
Opis fizyczny
Daty
wydano
2008-03-01
online
2008-03-26
Twórcy
  • Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, 182 51, Praha 8, Czech Republic, srobar@ufe.cz
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11534-008-0003-7
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