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2014 | 12 | 10 | 994-1007
Tytuł artykułu

Analytical methods for determination of benzodiazepines. A short review

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Benzodiazepines (BDZs) are generally commonly used as anxiolytic and/or hypnotic drugs as a ligand of the GABAA-benzodiazepine receptor. Moreover, some of benzodiazepines are widely used as an anti-depressive and sedative drugs, and also as anti-epileptic drugs and in some cases can be useful as an adjunct treatment in refractory epilepsies or anti-alcoholic therapy. High-performance liquid chromatography (HPLC) methods, thin-layer chromatography (TLC) methods, gas chromatography (GC) methods, capillary electrophoresis (CE) methods and some of spectrophotometric and spectrofluorometric methods were developed and have been extensively applied to the analysis of number of benzodiazepine derivative drugs (BDZs) providing reliable and accurate results. The available chemical methods for the determination of BDZs in biological materials and pharmaceutical formulations are reviewed in this work.
Wydawca

Czasopismo
Rocznik
Tom
12
Numer
10
Strony
994-1007
Opis fizyczny
Daty
wydano
2014-10-01
online
2014-05-15
Twórcy
  • Collegium Medicum of Nicolaus Copernicus University
autor
  • Collegium Medicum of Nicolaus Copernicus University
autor
  • Collegium Medicum of Nicolaus Copernicus University
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