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Czasopismo
2014 | 12 | 4 | 470-475
Tytuł artykułu

A validated stability-indicating LC method for simultaneous determination of quinapril and hydrochlorothiazide in pharmaceutical samples

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A stability-indicating liquid chromatographic method was developed and validated for simultaneous determination of quinapril and hydrochlorothiazide in drug substances and dosage forms. Chromatographic separation of quinapril, hydrochlorothiazide and its degradation products was achieved on a RP-18 column, using acetonitrile and phosphate buffer (pH 4.6) as mobile phase in a gradient mode and detection at 216 nm. Stress testing was performed under hydrolytic, oxidative, thermal and photolytic conditions. The degradation products were well resolved from main peaks, proving the stability-indicating power of the method. The assay was linear for quinapril and hydrochlorothiazide concentrations of 40–200 µg mL−1 and 25–125 µg mL−1, respectively. The developed method was selective, accurate and precise for quinapril and hydrochlorothiazide determination. This method was used to quantify both drugs in combined commercial tablets. The results showed that the proposed method was found to be suitable for quantitative determination and the stability study of quinapril and hydrochlorothiazide in pharmaceutical samples.
Wydawca

Czasopismo
Rocznik
Tom
12
Numer
4
Strony
470-475
Opis fizyczny
Daty
wydano
2014-04-01
online
2014-01-16
Twórcy
autor
  • University of Concepción
autor
  • University of Concepción
  • University of Concepción
  • University of Concepción
Bibliografia
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  • [23] ICH Q2B, Validation of Analytical Procedures, Methodology (International Conference on Harmonization, Geneva, 1996)
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0396-z
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